alkalinity

Discussion in 'Reef Fishes' started by Dinky, Feb 8, 2004.

  1. Dinky

    ReefTech Guest

    Looks to me like Boomer lost this one.


    "Dragon Slayer" <koi_man@nospam_hotmail.com> wrote in message
    news:c08a79$86iq$1@news3.infoave.net...
    > Boomer when you read that, just let it go.............no need bashing

    heads
    > here, the group knows what's going on.
    >
    > kc
    >
    > "stoutman" <.@.> wrote in message

    news:SFNVb.204571$Rc4.1681932@attbi_s54...
    > > Oh brother. Where to start.
    > >
    > > pH is the -log of the hydronium ion concentration. When the hydronium

    ion
    > > concentration is very low, your system is basic (high pH). When the
    > > hydronium ion concentration is very large, your system is acidic (low

    pH).
    > >
    > > pH + pOH = 14. So yeah, you can calculate a pH from a pOH and vice

    versa.
    > > But a pH of < 7 means acidic. pH > 7 means basic.
    > > pH can tell you something about acidity and basicity. It is a

    measurement
    > > of both, or the entire pH scale (1-14) if you will.
    > >
    > > >It is called "blowing it off" , such as with an airstone. If you have

    > high
    > > CO2 and add an airstone it will drive the CO2 off raising the pH.
    > >
    > > Ok, you are going to try and 'purge' (the correct term) your CO2 out

    with
    > > air. Yeah, I guess that would work. If you intentionally put the CO2

    in
    > > there to begin with because you must have a higher concentration of CO2

    in
    > > your tank than in the atmosphere. I don't intentionally put CO2 in my

    > tank.
    > > But I know some of you reef people due in Kalk reactors.
    > >
    > > >If Alk resists changes in pH then why does CO2 lower the pH without

    > > affecting the Alk.
    > >
    > > Alkalinity is buffering capacity. Your buffers begin to get weakened

    with
    > > the addition of acid until they reach a point when they can no longer
    > > 'buffer' and the pH crashes.
    > >
    > > >But I know what you mean, may use the term ALK and BC interchangeably

    > >
    > > Do you remember writing this in an earlier post? If you believe that
    > > alkalinity and buffering capacity can be used interchangeably than I

    must
    > be
    > > getting through to you.
    > >
    > > >When CO2 is added or remove it just changes the ratio of CO2:HCO3:CO3.

    At
    > > any pH no matter what the Alk or CO2 there will be an exact ratio of
    > > CO2:HCO3:CO3
    > >
    > > Yes, at any pH there will be 'SOME' ratio of CO2:HCO3-1:CO3-2. What is

    > your
    > > point here?
    > >
    > > > Go ahead and pick a seawater pH and I will tell you what that ratio

    is.
    > > Tell me the pH and
    > > > Alk and I will give the CO2 concentration. Give me the Alk and CO2

    and
    > I
    > > will give you
    > > > the pH. Don't forget the temperature and Salinity.

    > >
    > > Not interested. I can find my own software to do this too.
    > >
    > > > Alk is defined as;
    > > >
    > > > TA = [HCO3-] + 2[CO3--] + [B(OH)4-] + [OH-] + [Si(OH)3O-] + [MgOH+] +

    > > [HPO4--] +
    > > > 2[PO4---] - [H+]

    > >
    > > Ahh, now we are getting somewhere. What you are showing are components

    of
    > a
    > > 'BUFFER'. Which are used in the over all 'buffering capacity'. Are we
    > > going in circles here? Anyway, I think you are learning something.
    > >
    > > > In any aqueous solution maximum BC is reached when pH= pKa. Seawaters

    > > maximum BC is at a
    > > > pH of 6 & 9. For all practically purposes seawater has very little

    > > Buffering Capacity, if
    > > > any at all.

    > >
    > > This is the 'primary buffer' in sea water:
    > >
    > > H2O + CO2 <---> H2CO3 <---> H+ + HCO3-1
    > >
    > > If you REALLY believe that sea water has little buffering capacity, than

    > you
    > > need to do some reading on your own. I wont be able to convince you.
    > >
    > > > In any aqueous solution maximum BC is reached when pH= pKa. Seawaters

    > > maximum BC is at a
    > > > pH of 6 & 9. For all practically purposes seawater has very little

    > > Buffering Capacity, if
    > > > any at all.

    > >
    > > This would be true if a monoprotic acid where used in the 'buffer', but
    > > carbonic acid (the primary buffering component in seawater) is a

    > polyprotic
    > > acid. It has two protons that can dissociate. Therefore, it has two

    > pKa's
    > > (pKa1 and pKa2). pH = (pKa1 + pKa2)/2 pH = (6.4 + 10.3)/2 pH = 8.35.

    > The
    > > pH of seawater varies from 7.6 to 8.4. Hmmm. That pH I calculated is
    > > right in there. Is that magic? :)
    > >
    > > Remember that seawater is more than a mixture of just carbonate and CO2,
    > > there are other buffers involved that make it even more complicated I'm
    > > sure.
    > >
    > > > By the way do you know who you are talking to ?

    > >
    > > No. Do you?
    > >
    > >
    > >
    > >
    > > "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    > > news:102edca3c38a643@corp.supernews.com...
    > > > Let me make this clear you don't know what you are taking about
    > > >
    > > > "alkalinity is a measurement of 'buffering capacity'"
    > > >
    > > > No, it is the ability to neutralize an acid. BC is the ability to

    > > withstand both upward
    > > > and downward trends in pH.
    > > >
    > > > "pH is a measurement of 'acidity/basicity'.
    > > >
    > > > No, pH is a measurement of acidity and pOH is a measurement of

    Basicity,
    > > if you want to
    > > > get picky, which seems you do.
    > > >
    > > >
    > > > "How do you remove CO2? "
    > > >
    > > > It is called "blowing it off" , such as with an airstone. If you have

    > high
    > > CO2 and add an
    > > > airstone it will drive the CO2 off raising the pH. It can be proven

    with
    > a
    > > glass of water,
    > > > a straw, some pH color indicator and an Alk test kit and if you must a

    > CO2
    > > test kit
    > > >
    > > > >You can have all the alk you want in the world and it won't help, in
    > > > regards to CO2
    > > >
    > > > "Wrong. Alkalinity increases your tank's ability to RESIST sharp

    > changes
    > > in
    > > > pH. This is what is meant by 'buffering capacity'"
    > > >
    > > > No you are wrong and very lost. If Alk resists changes in pH then why

    > does
    > > CO2 lower the
    > > > pH without affecting the Alk ? CO2 has no effect on alk and alk has no

    > > effect on CO2. When
    > > > CO2 is added or remove it just changes the ratio of CO2:HCO3:CO3. At

    any
    > > pH no matter what
    > > > the Alk or CO2 there will be an exact ratio of CO2:HCO3:CO3
    > > >
    > > > .
    > > > Go ahead and pick a seawater pH and I will tell you what that ratio

    is.
    > > Tell me the pH and
    > > > Alk and I will give the CO2 concentration. Give me the Alk and CO2

    and
    > I
    > > will give you
    > > > the pH. Don't forget the temperature and Salinity.
    > > >
    > > > Alk is defined as;
    > > >
    > > > TA = [HCO3-] + 2[CO3--] + [B(OH)4-] + [OH-] + [Si(OH)3O-] + [MgOH+] +

    > > [HPO4--] +
    > > > 2[PO4---] - [H+]
    > > >
    > > >
    > > > Buffering Capacity is defined as;
    > > >
    > > > BC = dCb/dpH = 2.303 (Kw/ [H3O+] + [H30+] + CKa[H3O+] / (Ka +

    [H3O+])²
    > > >
    > > > In any aqueous solution maximum BC is reached when pH= pKa. Seawaters

    > > maximum BC is at a
    > > > pH of 6 & 9. For all practically purposes seawater has very little

    > > Buffering Capacity, if
    > > > any at all.
    > > >
    > > >
    > > > Alkalinity and Buffer Capacity are closely tied but are NOT the same

    > > thing, it is a
    > > > misunderstanding and use of the term. Do you think water chemistry

    books
    > > would have
    > > > separate sections on Alkalinity and Buffering Capacity if they were

    the
    > > same thing ?
    > > >
    > > > By the way do you know who you are talking to ?
    > > >
    > > > --
    > > > Boomer
    > > >
    > > > Want to talk chemistry ? The Reef Chemistry Forum
    > > > http://www.reefcentral.com/vbulletin/index.php
    > > >
    > > > Want to See More ?
    > > > Please Join Our Growing Membership
    > > > www.coralrealm.com
    > > >
    > > > If You See Me Running You Better Catch-Up
    > > >
    > > >

    > >
    > >

    >
    >
     
    ReefTech, Feb 10, 2004
    #41
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  2. Dinky

    Boomer Guest

    Now I am getting bored

    "Don't the components of a buffer account for the buffering capacity? Yes."

    Yes, agreed but you seem to fail what I'm saying. Buffering Capacity and Alkalinity are
    not the same, that has always been the issue. I gave the equation does that look like an
    Alkalinity equation or how Alk is determined. I see you had now comments on it what's
    wrong, why no comments on the equations I gave. Don't understand them or what ? Again this
    is the equation for Buffering Capacity, also called Buffer Index or Buffer Intensity. It
    is defined in most water chemistry and chemical oceanography text books.

    B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa [H3O+] / (Ka =
    H3O+])² )

    This is not Alkalinity now is it ?

    "I know how to do a titration, In fact I have done several. How many have
    you actually done? I don't mean by counting drops, I mean with a buret?"

    Well good for you, I use a Digital Titrator

    "Oh, I see,
    you think acidity is the opposite of alkalinity. In the world of CHEMISTRY
    it's not. Maybe in aquarium newsgroups it is.

    Hum no, maybe you should go for a look at HACH's or LaMotte website or the book I
    suggested earlier. Please view a copy.

    Standard Methods for the Examination of Water and Wastewater

    This book, over 2000 pages, is the guide for water testing. If you are reporting water
    test to the EPA you must use approved std from this text.I t is prepared and published by
    the EPA, American Water Works Association and American Public Health Association. You
    mean you don't have one and the issue is water chemistry

    You are confusing Acidity and Acidity as you know little about water chemistry and
    procedures and test methods

    From SMEWW, section 2-30, 2310 ACIDITY

    "Acidity of water is its quantative capacity to react with a strong base to a designated
    pH"

    This is how you test for it

    A std alkali titration to methyl orange or phenolphthalein
    endpoint.

    BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this book, there are
    over 100 of them, they are wrong.

    Like Buffering Capacity you have your Acidity's mixed up
    In water measurement if you have a high Alk you also usually have a high Acidity.
    Normally a high Alk also gives a higher CO2 level. Get a WATER CHEMISTRY BOOK there pal.


    "These are all in equilibrium with each other. An initial high pH (above
    6.4) will shift the equilibrium to the right to form HCO3-1. If the pH of
    the solution is above 10.3 (pKa2) the .........."


    Christ, there you go again with the FW shit. All your numbers are wrong we are dealing
    with SEAWATER

    This means that at a pH of 8.3, the majority of the CO2(aq) is in the form
    of HCO3-1 .

    I have already pointed that out and gave actual values at know seawater levels, go back
    and re-read it you aren't telling me anything here.Of course most is HCO3 see...


    @ 20C and 34.3 ppt salinity

    CO2 = 0.52 %

    HCO3 = 86.4 %

    CO3 = 13.09 %


    "In your glass experiment you managed to lower the pH enough to purge out CO2
    by boiling"

    The purpose behind the glass is to show that alk is not affect by CO2 and vise-versa and
    how Co2 affects pH.

    Now, in a real life seawater aquarium, with a pH of 8.3 and that pH drops to say 8.1 it is
    usually due to excess CO2. If you took a glass of that water and aerated it you WILL drive
    off the CO2 and raise the pH. It has been done a proven a million times.

    "In order to 'purge' CO2 you would need to lower the
    pH to shift the equilibrium to below 6.4"

    The hell you do !!!.Do you know who many times people on this NG to include Dr. Craig
    Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a sample of aquarium
    water and aerate it to see if the pH GOES UP AND when they come back with the test it is
    often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST excess CO2 in the tank
    water, increase the circulation for better gas exchange at the surface, reduce feeding,
    and try to improve on better skimming, thus reducing the bio-load and pH decline due to
    CO2.


    "I hope this helps. "

    Help, how can you when you miss everything. I should be charging you

    Oh, by the way. Your websites, I have about 50 on these issues, I could post them, not to
    mention I have all those water chemistry books, so there is no need to view your sites.

    Finally are you afraid to come to our Chemistry Forum, afraid to get slapped by REAL
    chemists. I get a charge out of you can't post your ref .I have posted the same or similar
    stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts there and am the
    biggest contributor to his forum other than himself or maybe Habib Sheka

    Hum, here are Randy's ref that he posted. He hosts the website

    S. RANDY HOLMES-FARLEY
    Arlington, Massachusetts

    EDUCATION

    1982-1986 Harvard University Cambridge, MA
    PhD in Chemistry
    Research Advisor: George Whitesides

    Investigated the relationship between polymer surface chemistry and physical properties
    through controlled surface modification and testing.

    1980-1982 Cornell University Ithaca, NY
    BA in Chemistry and Biology
    Graduated Summa Cum Laude
    Distinction in All Subjects
    Grade Point: 3.94/4.0
    Honors research: isolation and characterization of the subunit of CF1 enzyme


    1978-1979 Stanford University Palo Alto, CA
    Grade Point: 3.55/4.0


    EXPERIENCE

    1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    (bought out GelTex Pharmaceuticals in 2001)
    Vice President, Chemical Research 2001-present
    Senior Director, Chemical Research 1999-2001
    Director of Chemical Research 1997-1999
    Manager of Chemical Research 1995-1997
    Group Leader 1994-1995
    Senior Research Scientist 1992-1994

    Helped start GelTex as second employee

    Managed various research programs with multi-million dollar budgets

    Supervised research chemists (17+)

    Co-inventor of several polymeric pharmaceuticals and pharmaceutical candidates including
    Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride (FDA approved)

    Company Safety Officer for 3 years

    Chemical Hygiene Officer 2000-present




    1990-1992 GTE Corporation Waltham, MA
    Senior Member of Technical Staff
    Applied research involving polymer interfaces
    Metallization of plastics
    Polymer/polymer adhesion
    Optical coatings



    1986-1990 Lord Corporation Cary, NC
    Senior Research Scientist 1988-1990
    Research Scientist 1986-1988
    Basic and applied research on surface chemical bonding
    Developed new adhesive compositions
    Developed new sol-gel coatings for corrosion resistance


    HONORS AND AWARDS

    Industrial Innovations Award by Northeast Region of American Chemical Society (6/2001)

    National Kidney Foundation of Northern California Honoree (5/2001)

    American Chemical Society/Polymer Chemistry Division Industrial Sponsors
    Award (8/2000)

    R&D 100 Award from R&D magazine (1999)

    Sherwin Williams Award in applied polymer science (9/85)

    IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)

    Award for highest GPA in Chemistry Department (6/82)

    Summa Cum Laude Honors in Chemistry (6/82)

    Phi Lamda Epsilon (6/82)

    Phi Beta Kappa (2/82)

    Cornell University Dean's List (1981, 1982)

    Harvard Book Club Award for highest GPA senior year (1978)

    First Place in western NY ACS high school chemistry exam (1977)

    1978-1979


    __________________
    Randy Holmes-Farley
    Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central

    Hobby Experience: 8 years with reefs
    Current Tanks: 90 gal mixed reef
    Interests: Reefkeeping, science, photography


    Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM

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    06/27/2003 02:44 PM

    Randy Holmes-Farley
    Chemistry Moderator

    Registered: Apr 2001
    Location: Arlington, Massachusetts
    Occupation: Chemist (Drug Discovery at Genzyme)
    Posts: 15282



    Publications


    ISSUED UNITED STATES PATENTS


    1. Method for reducing oxalate. Holmes-Farley, Stephen Randall; Mandeville, III; W. Harry.
    US 6,566,407; 5/20/2003

    2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall; Huval, Chad
    Cori.
    U.S. 6,517,825; 2/11/2003.

    3. Method of making phosphate-binding polymers for oral administration. Holmes-Farley,
    Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S. 6,509,013; 1/21/2003.

    4. Combination therapy for treating hypercholesterolemia using a bile acid sequestrant
    polymer
    and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen Randall;
    Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.

    5. Method for treating hypercholesterolemia with polyallylamine polymers. Holmes-Farley,
    Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg, Dennis I. , US
    6,423,754; 7/23/2002.

    6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III; Neenan, Thomas X..;
    Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.

    7. Combination therapy for treating hypercholesterolemia and atherosclerosis. Huval, Chad
    Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K. U.S. 6,365,186;
    4/2/2002.

    8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville, W. H., III;
    Huval; C.
    C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868; 10/9/2001.

    9. Polymers containing guanidinium groups as bile acid sequestrants. Dhal; P. K.; Holmes-
    Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001

    10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H., III.; US
    6,281,252;
    8/28/2001.

    11. Combination therapy for treating hypercholestrolemia. Huval; C. C.; Holmes-Farley; S.
    R. ;
    Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.

    12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.; Holmes-Farley, S.
    R.; US
    6,264,937; 7/24/2001.

    13. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers.
    Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US 6,248,318;
    6/19/2001.

    14. Process for removing bile salts from a patient and alkylated compositions therefore.
    Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.

    15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.; Dhal, P. K.;
    Petersen,
    J. S.; US 6,203,785; 3/20/2001.

    16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval, C. C.; US
    6,190,649;
    2/20/2001.

    17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H., III.; US
    6,177,478;
    1/23/2001.

    18. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley, S. R.;
    Mandeville, W.
    H., III.; US 6,129,910; 10/10/2000.

    19. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers.
    Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US 6,083,497;
    7/4/2000.

    20. Method of making phosphate-binding polymers for oral administration. Holmes-Farley, S.
    R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.

    21. Process for removing bile salts from a patient and alkylated compositions therefore.
    Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.

    22. Process for removing bile salts from a patient and compositions therefor. Mandeville,
    W. H.,
    III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.

    23. Ionic polymers as anti-infective agents. Mandeville, III; W. H; Neenan; T. X.; Holmes-
    Farley; S. R. US 6,034,129; 3/7/2000.

    24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H., III.; US
    5,985,938;
    11/16/99.

    25. Process for removing bile salts from a patient and compositions therefor. Mandeville,
    W. H.,
    III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.

    26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H., III.;
    Holmes-Farley;
    S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.

    27. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile
    acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184; 7/27/99.

    28. Interpenetrating polymer networks for sequestration of bile acids. Mandeville, W. H.,
    III.;
    Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379; 7/20/99.

    29. Amine polymer sequestrant and method of cholesterol depletion. Mandeville, W. H.,
    III.;
    Holmes-Farley, S. R.; US 5,919,832; 7/6/99.

    30. Process for removing bile salts from a patient and compositions therefor. Mandeville,
    W. H.,
    III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.

    31. Polyamine salt hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H.,
    III.;
    Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.

    32. Process for removing bile salts from a patient and compositions therefor. Mandeville,
    W. H.,
    III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.

    33. Preparation of polymeric sequestrants for bile acid salts. Mandeville, W. H., III.;
    Holmes-
    Farley, S. R.; US 5,703,188; 12/30/97.

    34. Oral administration of iron-binding crosslinked amine polymers. Mandeville, W. H.,
    III.;
    Holmes-Farley, S. R.; US 5,702,696; 12/30/97.

    35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,693,675;
    12/2/97.

    36. Method for removing bile salts from a patient with alkylated crosslinked amine
    polymers,
    and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley, S. R.; US
    5,679,717; 10/21/97.

    37. Phosphate-binding polymers for oral administration. Holmes-Farley, S. R.; Mandeville,
    W.
    H., III.; US 5,667,775; 9/16/97.

    38. Ion-exchange process using highly crosslinked polymers for removing bile salts from a
    patient, preparation of the polymers, and compositions containing them. Mandeville, W. H.,
    III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.

    39. Hydrophobic amine polymer sequestrant and method of cholesterol depletion. Mandeville,
    W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.

    40. Amine polymer sequestrant and method of cholesterol depletion. Mandeville, W. H.,
    III.;
    Holmes-Farley, S. R.; US 5,607,669; 3/4/97.

    41. Phosphate-binding polymers for oral administration. Holmes-Farley, S. R.; Mandeville,
    W.
    H., III.; US 5,496,545; 3/5/96.

    42. Iron-binding polymers for oral administration. Mandeville, W. H., III.; Holmes-Farley,
    S. R.;
    US 5,487,888; 1/30/96.

    43. Ultra-thin, uniform sol-gel coating of a substrate having active hydrogens on the
    surface.
    Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.

    44. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley, S. R.; Yanyo, L.
    C.;
    US 5,182,143; 1/26/93.

    45. Method for metal bonding using ultrathin primer coating. Holmes-Farley, S. R.; Yanyo,
    L.
    C.; Thuer, A. M.; US 5,139,601; 8/18/92.

    46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US 5,096,962;
    3/17/92.

    47. Modified halogenatedpolyolefin adhesives for polyolefin elastomer-metal bonding.
    Holmes-
    Farley, S. R.; US 5,102,956; 4/7/92.



    PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)


    1. Aryl boronate functionalized polymers for treating obesity and inhibiting fat uptake.
    Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal, Pradeep K.; Huval, Chad
    Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92 pp. WO 0302571.

    2. Preparation of aryl boronic acids for treating obesity. Holmes-Farley, Stephen Randall;
    Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep K. (Geltex
    Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.

    3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley, Stephen Randall.
    (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO 0302130.

    4. Method for reducing copper levels and treating copper toxicosis. Holmes-Farley, Stephen
    Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45 pp. WO
    0285383.

    5. Method for treating gout and binding uric acid. Holmes-Farley, Stephen Randall; Burke,
    Steven K. WO 0285381 10/31/2002.

    6. Method for treating gout and reducing serum uric acid. Holmes-Farley, Stephen Randall;
    Burke, Steven K WO 0285380 10/31/2002.

    7. Amine condensation polymer bile acid sequestrants. Huval, C. C.; Holmes-Farley, S. R.;
    Whitesides, G. M. WO 1999-US30469; 7/6/2000.

    8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and Holmes-Farley, S.
    R.;
    WO 1999-US5662; 9/23/1999.

    9. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley, S. R.; Petersen,
    J. S.;
    WO 9933452; 7/8/1999.

    10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and Holmes-Farley, S.
    R.;
    WO 9922743; 5/14/1999.

    11. Polyallylamine polymers for removing bile salts and treating hypercholesterolemia, and
    polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke, S. K.; Goldberg,
    D. I.; WO 9857652; 12/23/98.

    12. Phosphate-bidning polymers combined with a calcium supplement for oral administration.
    Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S. R.; WO 9842355;
    10/1/98.

    13. Hydrophobic heteroatom-containing sequestrant for cholesterol depletion. Mandeville,
    W.
    H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.

    14. Process for adjusting ion concentration in a patient and compositions therefor.
    Mandeville,
    W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.

    15. Vacuum-deposited silver on polycarbonate with a chromium interlayer for improved
    metal-
    substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.

    16. Process for increased metal-substrate bond strength in metalized plastics.
    Holmes-Farley, S.
    R.; Ger. Offen. 4322516; 7/6/93.

    17. Electrorheological fluids and preparation of particles useful in the fluids.
    Troughton,
    Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J. David; Bares, Joseph
    E.;
    Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP 394049;
    10/24/1990.

    JOURNAL PUBLICATIONS

    1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene; Guo, Amy;
    Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.; Mandeville, W. Harry;
    Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.

    2. Amine functionalized polyethers as bile acid sequestrants: synthesis and biological
    evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall; Mandeville, W.
    Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K. Journal of
    Macromolecular Science, Pure and Applied Chemistry (2001), A38(12), 1559-1574.

    3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular Imprinting. Huval,
    Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S. Randall; Mandeville,
    W.
    Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.; Chen, Xi; Dhal,
    Pradeep K. Macromolecules (2001), 34(6), 1548-1550.

    4. Synthetic polymers for the binding of fat in the intestinal tract. Jozefiak, Thomas H.;
    Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval, Chad C.;
    Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia. Abstracts of
    Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001
    (2001), POLY-047 and Polymer Preprints (American Chemical Society, Division of
    Polymer Chemistry) (2001), 42(2), 98.

    5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel pharmaceutical.
    Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward, J.; Sacchiero,
    B.;
    Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen, X.; Mazzeo, J.
    R.. Polym. Preprints (2000), 41(1), 735-736.

    6. In vitro comparison of bile acid binding to colesevelam HCl and other bile acid
    sequestrants.
    Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.; Hook, P.; Holmes-
    Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.

    7. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley, S. R; Polym.
    Mater. Sci. Eng (1999), 80, 246-247.

    8. Design and characterization of of Sevelamer Hydrochloride: a novel phosphate-binding
    pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.; Miller, K. L.;
    Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and Appl. Chem.,
    A36(7&8), p. 1085 (1999).

    9. Three generations of bile acid sequestrants. Mandeville, W. H., III; Braunlin, W.;
    Dhal, P.;
    Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.; Rosenbaum, D.;
    Sacchiero,
    R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999), 550, 3-15.

    10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate binder, on
    urinary
    phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.; Mandeville, W. H.,
    III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant. (1997), 12(5)
    961-964.

    11. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley, S. R.; Yanyo, L.
    C;
    Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.

    12. The mechanism of cure initiation of a surface activated adhesive. Holmes-Farley, S.
    R.;
    Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.

    13. Adhesion promotion and corrosion prevention using thin anisotropic coatings. Holmes-
    Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2), 131-151.

    14. Wetting of functionalized polyethylene having ionizable organic acids and bases at the
    polymer-water interface: relations between functional group polarity, extent of
    ionization,
    and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.; Whitesides, G. M.;
    Langmuir
    (1988), 4(4), 921-937.

    15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a single hydroxy group.
    Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.

    16. Reconstruction of the interface of oxidatively functionalized polyethylene (PE-CO2H)
    and
    derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.; McCarthy, T. J.;
    Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987), AD-
    A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).

    17. Surface-modified polyethylene film: the relationship between surface chemistry and
    physical
    properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.

    18. Reactivity of carboxylic acid and ester groups in the functionalized interfacial
    region of
    "polyethylene carboxylic acid" (PE-CO2H) and its derivatives: differentiation of the
    functional groups into shallow and deep subsets based on a comparison of contact angle and
    ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir (1987), 3(1), 62-
    76.

    19. Fluorescence properties of dansyl groups covalently bonded tot he surface of
    oxidatively
    functionalized low-density polyethylene film. Holmes-Farley, S. R.; Whitesides, G. M.;
    Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2; AD-A162435/2/GAR,
    Gov. Rep. Announce. Index (U. S.) 1986, 86(7).

    20. Acid-base behavior of carboxylic acid groups covalently attached at the surface of
    polyethylene: The usefulness of contact angle in following the ionization of surface
    functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.; Deutch, J.;
    Whitesides,
    G. M.; Langmuir (1985), 1(6), 725-740.

    21. The thermal stability of a surface modified solid organic polymer. Holmes-Farley, S.
    R.;
    Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.



    CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)

    1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced Aquarist. June 2003.

    2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R. Advanced Aquarist.
    May
    2003.

    3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R. Reefkeeping May
    2003.

    4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping April 2003.

    5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth. Holmes-Farley, R.
    Advanced Aquarist; April 2003.

    6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth. Holmes-Farley, R.
    Advanced Aquarist; April 2003.

    7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced Aquarist; March 2003.

    8. How to Select a Calcium and Alkalinity Supplementation Scheme. Holmes-Farley, R.
    Advanced Aquarist; February 2003.

    9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January 2003.

    10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; December 2002.

    11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R. Advanced Aquarist; November
    2002.

    12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R. Advanced Aquarist;
    November 2002.

    13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced Aquarist, September 2002.

    14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August 2002.

    15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April 2002.

    16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced Aquarist; July 2002

    17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist; June 2002.

    18. The Relationship Between Alkalinity and pH. Holmes-Farley, R. Advanced Aquarist, May
    2002.

    19. The Chemical & Biochemical Mechanisms of Calcification in Corals. Holmes-Farley, R.
    Advanced Aquarist, April 2002.

    20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.

    21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.

    22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January 2002.

    23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers 2000.

    24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium Frontiers 2000.

    25. Phosphate..What is it and why should you care. Holmes-Farley, R. Aquarium Frontiers
    2000.
    26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium Frontiers 2000.

    27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers 2000.

    28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.

    29. Protein Skimming: How it Works. Fishnet Library 1998.







    Boomer

    Want to talk chemistry ? The Reef Chemistry Forum
    http://www.reefcentral.com/vbulletin/index.php

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    Please Join Our Growing Membership
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    Boomer, Feb 10, 2004
    #42
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  3. Dinky

    stoutman Guest

    I never said alkalinity and buffering capacity are the same thing. When did
    I say that? Now you are twisting my words.

    What I said was :alkalinity is a measurement of 'buffering capacity' GET
    IT?

    > Hum no, maybe you should go for a look at HACH's or LaMotte website or the

    book I
    > suggested earlier. Please view a copy.


    Another Marine Biologist. I don't think so.


    > You are confusing Acidity and Acidity as you know little about water

    chemistry and
    > procedures and test methods


    I'm confusing 'Acidity' and 'Acidity' What? Ok, now I really think you
    are an idiot.

    > Like Buffering Capacity you have your Acidity's mixed up


    ACIDITY IS the opposite of BASICITY. You are an idiot!

    > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this

    book, there are
    > over 100 of them, they are wrong.



    Ok, if that's what they think than they are wrong. I haven't read there
    books, I will take your word for it. If their logic is the same as yours,
    their WRONG as well.

    > Christ, there you go again with the FW shit. All your numbers are wrong we

    are dealing
    > with SEAWATER


    You didn't say in your experiment that sea water was being used. The HH
    equation STILL applies.

    > Oh, by the way. Your websites, I have about 50 on these issues, I could

    post them, not to
    > mention I have all those water chemistry books, so there is no need to

    view your sites.

    I could of posted more web sites for ya, but I didn't want you to get even
    more confused than you already are. I tried to keep it simple for ya. Did
    you go to those web pages and actually read them? Maybe you should send
    them an e-mail and tell them their web pages are wrong and that they are
    offending all the marine biologists across the country.

    > Finally are you afraid to come to our Chemistry Forum, afraid to get

    slapped by REAL
    > chemists. I get a charge out of you can't post your ref .I have posted the

    same or similar
    > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts

    there and am the
    > biggest contributor to his forum other than himself or maybe Habib Sheka


    No Boomer. I'm not afraid, just VERY uninterested in explaining chemistry
    to other LAYMAN such as yourself. I use to get paid this in grad school
    (tutoring).

    Why are you posting someone elses C.V.? Is that meant to impress me? I'm
    writing to Boomer right? Not RANDY HOLMES-FARLEY. Right? If you want to
    post a C.V., why not post yours? I'm sure it's just as impressive, right?

    GET A CLUE!







    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102ht0bjplpo059@corp.supernews.com...
    > Now I am getting bored
    >
    > "Don't the components of a buffer account for the buffering capacity?

    Yes."
    >
    > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity and

    Alkalinity are
    > not the same, that has always been the issue. I gave the equation does

    that look like an
    > Alkalinity equation or how Alk is determined. I see you had now comments

    on it what's
    > wrong, why no comments on the equations I gave. Don't understand them or

    what ? Again this
    > is the equation for Buffering Capacity, also called Buffer Index or Buffer

    Intensity. It
    > is defined in most water chemistry and chemical oceanography text books.
    >
    > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa

    [H3O+] / (Ka =
    > H3O+])² )
    >
    > This is not Alkalinity now is it ?
    >
    > "I know how to do a titration, In fact I have done several. How many have
    > you actually done? I don't mean by counting drops, I mean with a buret?"
    >
    > Well good for you, I use a Digital Titrator
    >
    > "Oh, I see,
    > you think acidity is the opposite of alkalinity. In the world of

    CHEMISTRY
    > it's not. Maybe in aquarium newsgroups it is.
    >
    > Hum no, maybe you should go for a look at HACH's or LaMotte website or the

    book I
    > suggested earlier. Please view a copy.
    >
    > Standard Methods for the Examination of Water and Wastewater
    >
    > This book, over 2000 pages, is the guide for water testing. If you are

    reporting water
    > test to the EPA you must use approved std from this text.I t is prepared

    and published by
    > the EPA, American Water Works Association and American Public Health

    Association. You
    > mean you don't have one and the issue is water chemistry
    >
    > You are confusing Acidity and Acidity as you know little about water

    chemistry and
    > procedures and test methods
    >
    > From SMEWW, section 2-30, 2310 ACIDITY
    >
    > "Acidity of water is its quantative capacity to react with a strong base

    to a designated
    > pH"
    >
    > This is how you test for it
    >
    > A std alkali titration to methyl orange or phenolphthalein
    > endpoint.
    >
    > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this

    book, there are
    > over 100 of them, they are wrong.
    >
    > Like Buffering Capacity you have your Acidity's mixed up
    > In water measurement if you have a high Alk you also usually have a high

    Acidity.
    > Normally a high Alk also gives a higher CO2 level. Get a WATER CHEMISTRY

    BOOK there pal.
    >
    >
    > "These are all in equilibrium with each other. An initial high pH (above
    > 6.4) will shift the equilibrium to the right to form HCO3-1. If the pH of
    > the solution is above 10.3 (pKa2) the .........."
    >
    >
    > Christ, there you go again with the FW shit. All your numbers are wrong we

    are dealing
    > with SEAWATER
    >
    > This means that at a pH of 8.3, the majority of the CO2(aq) is in the form
    > of HCO3-1 .
    >
    > I have already pointed that out and gave actual values at know seawater

    levels, go back
    > and re-read it you aren't telling me anything here.Of course most is HCO3

    see...
    >
    >
    > @ 20C and 34.3 ppt salinity
    >
    > CO2 = 0.52 %
    >
    > HCO3 = 86.4 %
    >
    > CO3 = 13.09 %
    >
    >
    > "In your glass experiment you managed to lower the pH enough to purge out

    CO2
    > by boiling"
    >
    > The purpose behind the glass is to show that alk is not affect by CO2 and

    vise-versa and
    > how Co2 affects pH.
    >
    > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH drops

    to say 8.1 it is
    > usually due to excess CO2. If you took a glass of that water and aerated

    it you WILL drive
    > off the CO2 and raise the pH. It has been done a proven a million times.
    >
    > "In order to 'purge' CO2 you would need to lower the
    > pH to shift the equilibrium to below 6.4"
    >
    > The hell you do !!!.Do you know who many times people on this NG to

    include Dr. Craig
    > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a

    sample of aquarium
    > water and aerate it to see if the pH GOES UP AND when they come back with

    the test it is
    > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST excess

    CO2 in the tank
    > water, increase the circulation for better gas exchange at the surface,

    reduce feeding,
    > and try to improve on better skimming, thus reducing the bio-load and pH

    decline due to
    > CO2.
    >
    >
    > "I hope this helps. "
    >
    > Help, how can you when you miss everything. I should be charging you
    >
    > Oh, by the way. Your websites, I have about 50 on these issues, I could

    post them, not to
    > mention I have all those water chemistry books, so there is no need to

    view your sites.
    >
    > Finally are you afraid to come to our Chemistry Forum, afraid to get

    slapped by REAL
    > chemists. I get a charge out of you can't post your ref .I have posted the

    same or similar
    > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts

    there and am the
    > biggest contributor to his forum other than himself or maybe Habib Sheka
    >
    > Hum, here are Randy's ref that he posted. He hosts the website
    >
    > S. RANDY HOLMES-FARLEY
    > Arlington, Massachusetts
    >
    > EDUCATION
    >
    > 1982-1986 Harvard University Cambridge, MA
    > PhD in Chemistry
    > Research Advisor: George Whitesides
    >
    > Investigated the relationship between polymer surface chemistry and

    physical properties
    > through controlled surface modification and testing.
    >
    > 1980-1982 Cornell University Ithaca, NY
    > BA in Chemistry and Biology
    > Graduated Summa Cum Laude
    > Distinction in All Subjects
    > Grade Point: 3.94/4.0
    > Honors research: isolation and characterization of the subunit of CF1

    enzyme
    >
    >
    > 1978-1979 Stanford University Palo Alto, CA
    > Grade Point: 3.55/4.0
    >
    >
    > EXPERIENCE
    >
    > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > (bought out GelTex Pharmaceuticals in 2001)
    > Vice President, Chemical Research 2001-present
    > Senior Director, Chemical Research 1999-2001
    > Director of Chemical Research 1997-1999
    > Manager of Chemical Research 1995-1997
    > Group Leader 1994-1995
    > Senior Research Scientist 1992-1994
    >
    > Helped start GelTex as second employee
    >
    > Managed various research programs with multi-million dollar budgets
    >
    > Supervised research chemists (17+)
    >
    > Co-inventor of several polymeric pharmaceuticals and pharmaceutical

    candidates including
    > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride (FDA

    approved)
    >
    > Company Safety Officer for 3 years
    >
    > Chemical Hygiene Officer 2000-present
    >
    >
    >
    >
    > 1990-1992 GTE Corporation Waltham, MA
    > Senior Member of Technical Staff
    > Applied research involving polymer interfaces
    > Metallization of plastics
    > Polymer/polymer adhesion
    > Optical coatings
    >
    >
    >
    > 1986-1990 Lord Corporation Cary, NC
    > Senior Research Scientist 1988-1990
    > Research Scientist 1986-1988
    > Basic and applied research on surface chemical bonding
    > Developed new adhesive compositions
    > Developed new sol-gel coatings for corrosion resistance
    >
    >
    > HONORS AND AWARDS
    >
    > Industrial Innovations Award by Northeast Region of American Chemical

    Society (6/2001)
    >
    > National Kidney Foundation of Northern California Honoree (5/2001)
    >
    > American Chemical Society/Polymer Chemistry Division Industrial Sponsors
    > Award (8/2000)
    >
    > R&D 100 Award from R&D magazine (1999)
    >
    > Sherwin Williams Award in applied polymer science (9/85)
    >
    > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    >
    > Award for highest GPA in Chemistry Department (6/82)
    >
    > Summa Cum Laude Honors in Chemistry (6/82)
    >
    > Phi Lamda Epsilon (6/82)
    >
    > Phi Beta Kappa (2/82)
    >
    > Cornell University Dean's List (1981, 1982)
    >
    > Harvard Book Club Award for highest GPA senior year (1978)
    >
    > First Place in western NY ACS high school chemistry exam (1977)
    >
    > 1978-1979
    >
    >
    > __________________
    > Randy Holmes-Farley
    > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    >
    > Hobby Experience: 8 years with reefs
    > Current Tanks: 90 gal mixed reef
    > Interests: Reefkeeping, science, photography
    >
    >
    > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    >
    > Open this post in a new window | Report this post to a moderator | IP:

    Logged
    >
    >
    >
    > 06/27/2003 02:44 PM
    >
    > Randy Holmes-Farley
    > Chemistry Moderator
    >
    > Registered: Apr 2001
    > Location: Arlington, Massachusetts
    > Occupation: Chemist (Drug Discovery at Genzyme)
    > Posts: 15282
    >
    >
    >
    > Publications
    >
    >
    > ISSUED UNITED STATES PATENTS
    >
    >
    > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;

    Mandeville, III; W. Harry.
    > US 6,566,407; 5/20/2003
    >
    > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall;

    Huval, Chad
    > Cori.
    > U.S. 6,517,825; 2/11/2003.
    >
    > 3. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley,
    > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.

    6,509,013; 1/21/2003.
    >
    > 4. Combination therapy for treating hypercholesterolemia using a bile acid

    sequestrant
    > polymer
    > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen

    Randall;
    > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    >
    > 5. Method for treating hypercholesterolemia with polyallylamine polymers.

    Holmes-Farley,
    > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg,

    Dennis I. , US
    > 6,423,754; 7/23/2002.
    >
    > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;

    Neenan, Thomas X..;
    > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    >
    > 7. Combination therapy for treating hypercholesterolemia and

    atherosclerosis. Huval, Chad
    > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K.

    U.S. 6,365,186;
    > 4/2/2002.
    >
    > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville,

    W. H., III;
    > Huval; C.
    > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;

    10/9/2001.
    >
    > 9. Polymers containing guanidinium groups as bile acid sequestrants. Dhal;

    P. K.; Holmes-
    > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    >
    > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,281,252;
    > 8/28/2001.
    >
    > 11. Combination therapy for treating hypercholestrolemia. Huval; C. C.;

    Holmes-Farley; S.
    > R. ;
    > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    >
    > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;

    Holmes-Farley, S.
    > R.; US
    > 6,264,937; 7/24/2001.
    >
    > 13. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,248,318;
    > 6/19/2001.
    >
    > 14. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    >
    > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.;

    Dhal, P. K.;
    > Petersen,
    > J. S.; US 6,203,785; 3/20/2001.
    >
    > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval,

    C. C.; US
    > 6,190,649;
    > 2/20/2001.
    >
    > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,177,478;
    > 1/23/2001.
    >
    > 18. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley,

    S. R.;
    > Mandeville, W.
    > H., III.; US 6,129,910; 10/10/2000.
    >
    > 19. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,083,497;
    > 7/4/2000.
    >
    > 20. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley, S.
    > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.
    >
    > 21. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.
    >
    > 22. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    >
    > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;

    Neenan; T. X.; Holmes-
    > Farley; S. R. US 6,034,129; 3/7/2000.
    >
    > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 5,985,938;
    > 11/16/99.
    >
    > 25. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    >
    > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H.,

    III.;
    > Holmes-Farley;
    > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    >
    > 27. Hydrophilic nonamine-containing and amine-containing copolymers and

    their use as bile
    > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184;

    7/27/99.
    >
    > 28. Interpenetrating polymer networks for sequestration of bile acids.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;

    7/20/99.
    >
    > 29. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    >
    > 30. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    >
    > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    >
    > 32. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    >
    > 33. Preparation of polymeric sequestrants for bile acid salts. Mandeville,

    W. H., III.;
    > Holmes-
    > Farley, S. R.; US 5,703,188; 12/30/97.
    >
    > 34. Oral administration of iron-binding crosslinked amine polymers.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    >
    > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S.

    R.; US 5,693,675;
    > 12/2/97.
    >
    > 36. Method for removing bile salts from a patient with alkylated

    crosslinked amine
    > polymers,
    > and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley,

    S. R.; US
    > 5,679,717; 10/21/97.
    >
    > 37. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,667,775; 9/16/97.
    >
    > 38. Ion-exchange process using highly crosslinked polymers for removing

    bile salts from a
    > patient, preparation of the polymers, and compositions containing them.

    Mandeville, W. H.,
    > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    >
    > 39. Hydrophobic amine polymer sequestrant and method of cholesterol

    depletion. Mandeville,
    > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.
    >
    > 40. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    >
    > 41. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,496,545; 3/5/96.
    >
    > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,

    III.; Holmes-Farley,
    > S. R.;
    > US 5,487,888; 1/30/96.
    >
    > 43. Ultra-thin, uniform sol-gel coating of a substrate having active

    hydrogens on the
    > surface.
    > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    >
    > 44. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley,

    S. R.; Yanyo, L.
    > C.;
    > US 5,182,143; 1/26/93.
    >
    > 45. Method for metal bonding using ultrathin primer coating.

    Holmes-Farley, S. R.; Yanyo,
    > L.
    > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    >
    > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US

    5,096,962;
    > 3/17/92.
    >
    > 47. Modified halogenatedpolyolefin adhesives for polyolefin

    elastomer-metal bonding.
    > Holmes-
    > Farley, S. R.; US 5,102,956; 4/7/92.
    >
    >
    >
    > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    >
    >
    > 1. Aryl boronate functionalized polymers for treating obesity and

    inhibiting fat uptake.
    > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal, Pradeep

    K.; Huval, Chad
    > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92 pp. WO

    0302571.
    >
    > 2. Preparation of aryl boronic acids for treating obesity. Holmes-Farley,

    Stephen Randall;
    > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep K.

    (Geltex
    > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    >
    > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,

    Stephen Randall.
    > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO

    0302130.
    >
    > 4. Method for reducing copper levels and treating copper toxicosis.

    Holmes-Farley, Stephen
    > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45

    pp. WO
    > 0285383.
    >
    > 5. Method for treating gout and binding uric acid. Holmes-Farley, Stephen

    Randall; Burke,
    > Steven K. WO 0285381 10/31/2002.
    >
    > 6. Method for treating gout and reducing serum uric acid. Holmes-Farley,

    Stephen Randall;
    > Burke, Steven K WO 0285380 10/31/2002.
    >
    > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;

    Holmes-Farley, S. R.;
    > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    >
    > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 1999-US5662; 9/23/1999.
    >
    > 9. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley,

    S. R.; Petersen,
    > J. S.;
    > WO 9933452; 7/8/1999.
    >
    > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 9922743; 5/14/1999.
    >
    > 11. Polyallylamine polymers for removing bile salts and treating

    hypercholesterolemia, and
    > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke,

    S. K.; Goldberg,
    > D. I.; WO 9857652; 12/23/98.
    >
    > 12. Phosphate-bidning polymers combined with a calcium supplement for oral

    administration.
    > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S.

    R.; WO 9842355;
    > 10/1/98.
    >
    > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol

    depletion. Mandeville,
    > W.
    > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    >
    > 14. Process for adjusting ion concentration in a patient and compositions

    therefor.
    > Mandeville,
    > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    >
    > 15. Vacuum-deposited silver on polycarbonate with a chromium interlayer

    for improved
    > metal-
    > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.
    >
    > 16. Process for increased metal-substrate bond strength in metalized

    plastics.
    > Holmes-Farley, S.
    > R.; Ger. Offen. 4322516; 7/6/93.
    >
    > 17. Electrorheological fluids and preparation of particles useful in the

    fluids.
    > Troughton,
    > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.

    David; Bares, Joseph
    > E.;
    > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP

    394049;
    > 10/24/1990.
    >
    > JOURNAL PUBLICATIONS
    >
    > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene;

    Guo, Amy;
    > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;

    Mandeville, W. Harry;
    > Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.
    >
    > 2. Amine functionalized polyethers as bile acid sequestrants: synthesis

    and biological
    > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall;

    Mandeville, W.
    > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.

    Journal of
    > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),

    1559-1574.
    >
    > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular

    Imprinting. Huval,
    > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.

    Randall; Mandeville,
    > W.
    > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.;

    Chen, Xi; Dhal,
    > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    >
    > 4. Synthetic polymers for the binding of fat in the intestinal tract.

    Jozefiak, Thomas H.;
    > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval,

    Chad C.;
    > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.

    Abstracts of
    > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August

    26-30, 2001
    > (2001), POLY-047 and Polymer Preprints (American Chemical Society,

    Division of
    > Polymer Chemistry) (2001), 42(2), 98.
    >
    > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel

    pharmaceutical.
    > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward,

    J.; Sacchiero,
    > B.;
    > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen,

    X.; Mazzeo, J.
    > R.. Polym. Preprints (2000), 41(1), 735-736.
    >
    > 6. In vitro comparison of bile acid binding to colesevelam HCl and other

    bile acid
    > sequestrants.
    > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;

    Hook, P.; Holmes-
    > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    >
    > 7. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley,

    S. R; Polym.
    > Mater. Sci. Eng (1999), 80, 246-247.
    >
    > 8. Design and characterization of of Sevelamer Hydrochloride: a novel

    phosphate-binding
    > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.;

    Miller, K. L.;
    > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and

    Appl. Chem.,
    > A36(7&8), p. 1085 (1999).
    >
    > 9. Three generations of bile acid sequestrants. Mandeville, W. H., III;

    Braunlin, W.;
    > Dhal, P.;
    > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;

    Rosenbaum, D.;
    > Sacchiero,
    > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),

    550, 3-15.
    >
    > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate

    binder, on
    > urinary
    > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;

    Mandeville, W. H.,
    > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.

    (1997), 12(5)
    > 961-964.
    >
    > 11. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley,

    S. R.; Yanyo, L.
    > C;
    > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.
    >
    > 12. The mechanism of cure initiation of a surface activated adhesive.

    Holmes-Farley, S.
    > R.;
    > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    >
    > 13. Adhesion promotion and corrosion prevention using thin anisotropic

    coatings. Holmes-
    > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),

    131-151.
    >
    > 14. Wetting of functionalized polyethylene having ionizable organic acids

    and bases at the
    > polymer-water interface: relations between functional group polarity,

    extent of
    > ionization,
    > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;

    Whitesides, G. M.;
    > Langmuir
    > (1988), 4(4), 921-937.
    >
    > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a

    single hydroxy group.
    > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    >
    > 16. Reconstruction of the interface of oxidatively functionalized

    polyethylene (PE-CO2H)
    > and
    > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.;

    McCarthy, T. J.;
    > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987),

    AD-
    > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    >
    > 17. Surface-modified polyethylene film: the relationship between surface

    chemistry and
    > physical
    > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.
    >
    > 18. Reactivity of carboxylic acid and ester groups in the functionalized

    interfacial
    > region of
    > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:

    differentiation of the
    > functional groups into shallow and deep subsets based on a comparison of

    contact angle and
    > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir

    (1987), 3(1), 62-
    > 76.
    >
    > 19. Fluorescence properties of dansyl groups covalently bonded tot he

    surface of
    > oxidatively
    > functionalized low-density polyethylene film. Holmes-Farley, S. R.;

    Whitesides, G. M.;
    > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;

    AD-A162435/2/GAR,
    > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    >
    > 20. Acid-base behavior of carboxylic acid groups covalently attached at

    the surface of
    > polyethylene: The usefulness of contact angle in following the ionization

    of surface
    > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;

    Deutch, J.;
    > Whitesides,
    > G. M.; Langmuir (1985), 1(6), 725-740.
    >
    > 21. The thermal stability of a surface modified solid organic polymer.

    Holmes-Farley, S.
    > R.;
    > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    >
    >
    >
    > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    >
    > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced

    Aquarist. June 2003.
    >
    > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.

    Advanced Aquarist.
    > May
    > 2003.
    >
    > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.

    Reefkeeping May
    > 2003.
    >
    > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping

    April 2003.
    >
    > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced Aquarist;

    March 2003.
    >
    > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.

    Holmes-Farley, R.
    > Advanced Aquarist; February 2003.
    >
    > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January

    2003.
    >
    > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; December

    2002.
    >
    > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R. Advanced

    Aquarist; November
    > 2002.
    >
    > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.

    Advanced Aquarist;
    > November 2002.
    >
    > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced Aquarist,

    September 2002.
    >
    > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August

    2002.
    >
    > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April

    2002.
    >
    > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced

    Aquarist; July 2002
    >
    > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist; June

    2002.
    >
    > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R. Advanced

    Aquarist, May
    > 2002.
    >
    > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.

    Holmes-Farley, R.
    > Advanced Aquarist, April 2002.
    >
    > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    >
    > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    >
    > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January 2002.
    >
    > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium

    Frontiers 2000.
    >
    > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.

    Aquarium Frontiers
    > 2000.
    > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers 2000.
    >
    > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    >
    > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    >
    >
    >
    >
    >
    >
    >
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    >
    >
     
    stoutman, Feb 10, 2004
    #43
  4. Dinky

    stoutman Guest

    http://kywater.org/ww/ramp/rmalk.htm

    READ THE VERY FIRST LINE BOOMER!!!!!













    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102ht0bjplpo059@corp.supernews.com...
    > Now I am getting bored
    >
    > "Don't the components of a buffer account for the buffering capacity?

    Yes."
    >
    > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity and

    Alkalinity are
    > not the same, that has always been the issue. I gave the equation does

    that look like an
    > Alkalinity equation or how Alk is determined. I see you had now comments

    on it what's
    > wrong, why no comments on the equations I gave. Don't understand them or

    what ? Again this
    > is the equation for Buffering Capacity, also called Buffer Index or Buffer

    Intensity. It
    > is defined in most water chemistry and chemical oceanography text books.
    >
    > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa

    [H3O+] / (Ka =
    > H3O+])² )
    >
    > This is not Alkalinity now is it ?
    >
    > "I know how to do a titration, In fact I have done several. How many have
    > you actually done? I don't mean by counting drops, I mean with a buret?"
    >
    > Well good for you, I use a Digital Titrator
    >
    > "Oh, I see,
    > you think acidity is the opposite of alkalinity. In the world of

    CHEMISTRY
    > it's not. Maybe in aquarium newsgroups it is.
    >
    > Hum no, maybe you should go for a look at HACH's or LaMotte website or the

    book I
    > suggested earlier. Please view a copy.
    >
    > Standard Methods for the Examination of Water and Wastewater
    >
    > This book, over 2000 pages, is the guide for water testing. If you are

    reporting water
    > test to the EPA you must use approved std from this text.I t is prepared

    and published by
    > the EPA, American Water Works Association and American Public Health

    Association. You
    > mean you don't have one and the issue is water chemistry
    >
    > You are confusing Acidity and Acidity as you know little about water

    chemistry and
    > procedures and test methods
    >
    > From SMEWW, section 2-30, 2310 ACIDITY
    >
    > "Acidity of water is its quantative capacity to react with a strong base

    to a designated
    > pH"
    >
    > This is how you test for it
    >
    > A std alkali titration to methyl orange or phenolphthalein
    > endpoint.
    >
    > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this

    book, there are
    > over 100 of them, they are wrong.
    >
    > Like Buffering Capacity you have your Acidity's mixed up
    > In water measurement if you have a high Alk you also usually have a high

    Acidity.
    > Normally a high Alk also gives a higher CO2 level. Get a WATER CHEMISTRY

    BOOK there pal.
    >
    >
    > "These are all in equilibrium with each other. An initial high pH (above
    > 6.4) will shift the equilibrium to the right to form HCO3-1. If the pH of
    > the solution is above 10.3 (pKa2) the .........."
    >
    >
    > Christ, there you go again with the FW shit. All your numbers are wrong we

    are dealing
    > with SEAWATER
    >
    > This means that at a pH of 8.3, the majority of the CO2(aq) is in the form
    > of HCO3-1 .
    >
    > I have already pointed that out and gave actual values at know seawater

    levels, go back
    > and re-read it you aren't telling me anything here.Of course most is HCO3

    see...
    >
    >
    > @ 20C and 34.3 ppt salinity
    >
    > CO2 = 0.52 %
    >
    > HCO3 = 86.4 %
    >
    > CO3 = 13.09 %
    >
    >
    > "In your glass experiment you managed to lower the pH enough to purge out

    CO2
    > by boiling"
    >
    > The purpose behind the glass is to show that alk is not affect by CO2 and

    vise-versa and
    > how Co2 affects pH.
    >
    > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH drops

    to say 8.1 it is
    > usually due to excess CO2. If you took a glass of that water and aerated

    it you WILL drive
    > off the CO2 and raise the pH. It has been done a proven a million times.
    >
    > "In order to 'purge' CO2 you would need to lower the
    > pH to shift the equilibrium to below 6.4"
    >
    > The hell you do !!!.Do you know who many times people on this NG to

    include Dr. Craig
    > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a

    sample of aquarium
    > water and aerate it to see if the pH GOES UP AND when they come back with

    the test it is
    > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST excess

    CO2 in the tank
    > water, increase the circulation for better gas exchange at the surface,

    reduce feeding,
    > and try to improve on better skimming, thus reducing the bio-load and pH

    decline due to
    > CO2.
    >
    >
    > "I hope this helps. "
    >
    > Help, how can you when you miss everything. I should be charging you
    >
    > Oh, by the way. Your websites, I have about 50 on these issues, I could

    post them, not to
    > mention I have all those water chemistry books, so there is no need to

    view your sites.
    >
    > Finally are you afraid to come to our Chemistry Forum, afraid to get

    slapped by REAL
    > chemists. I get a charge out of you can't post your ref .I have posted the

    same or similar
    > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts

    there and am the
    > biggest contributor to his forum other than himself or maybe Habib Sheka
    >
    > Hum, here are Randy's ref that he posted. He hosts the website
    >
    > S. RANDY HOLMES-FARLEY
    > Arlington, Massachusetts
    >
    > EDUCATION
    >
    > 1982-1986 Harvard University Cambridge, MA
    > PhD in Chemistry
    > Research Advisor: George Whitesides
    >
    > Investigated the relationship between polymer surface chemistry and

    physical properties
    > through controlled surface modification and testing.
    >
    > 1980-1982 Cornell University Ithaca, NY
    > BA in Chemistry and Biology
    > Graduated Summa Cum Laude
    > Distinction in All Subjects
    > Grade Point: 3.94/4.0
    > Honors research: isolation and characterization of the subunit of CF1

    enzyme
    >
    >
    > 1978-1979 Stanford University Palo Alto, CA
    > Grade Point: 3.55/4.0
    >
    >
    > EXPERIENCE
    >
    > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > (bought out GelTex Pharmaceuticals in 2001)
    > Vice President, Chemical Research 2001-present
    > Senior Director, Chemical Research 1999-2001
    > Director of Chemical Research 1997-1999
    > Manager of Chemical Research 1995-1997
    > Group Leader 1994-1995
    > Senior Research Scientist 1992-1994
    >
    > Helped start GelTex as second employee
    >
    > Managed various research programs with multi-million dollar budgets
    >
    > Supervised research chemists (17+)
    >
    > Co-inventor of several polymeric pharmaceuticals and pharmaceutical

    candidates including
    > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride (FDA

    approved)
    >
    > Company Safety Officer for 3 years
    >
    > Chemical Hygiene Officer 2000-present
    >
    >
    >
    >
    > 1990-1992 GTE Corporation Waltham, MA
    > Senior Member of Technical Staff
    > Applied research involving polymer interfaces
    > Metallization of plastics
    > Polymer/polymer adhesion
    > Optical coatings
    >
    >
    >
    > 1986-1990 Lord Corporation Cary, NC
    > Senior Research Scientist 1988-1990
    > Research Scientist 1986-1988
    > Basic and applied research on surface chemical bonding
    > Developed new adhesive compositions
    > Developed new sol-gel coatings for corrosion resistance
    >
    >
    > HONORS AND AWARDS
    >
    > Industrial Innovations Award by Northeast Region of American Chemical

    Society (6/2001)
    >
    > National Kidney Foundation of Northern California Honoree (5/2001)
    >
    > American Chemical Society/Polymer Chemistry Division Industrial Sponsors
    > Award (8/2000)
    >
    > R&D 100 Award from R&D magazine (1999)
    >
    > Sherwin Williams Award in applied polymer science (9/85)
    >
    > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    >
    > Award for highest GPA in Chemistry Department (6/82)
    >
    > Summa Cum Laude Honors in Chemistry (6/82)
    >
    > Phi Lamda Epsilon (6/82)
    >
    > Phi Beta Kappa (2/82)
    >
    > Cornell University Dean's List (1981, 1982)
    >
    > Harvard Book Club Award for highest GPA senior year (1978)
    >
    > First Place in western NY ACS high school chemistry exam (1977)
    >
    > 1978-1979
    >
    >
    > __________________
    > Randy Holmes-Farley
    > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    >
    > Hobby Experience: 8 years with reefs
    > Current Tanks: 90 gal mixed reef
    > Interests: Reefkeeping, science, photography
    >
    >
    > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    >
    > Open this post in a new window | Report this post to a moderator | IP:

    Logged
    >
    >
    >
    > 06/27/2003 02:44 PM
    >
    > Randy Holmes-Farley
    > Chemistry Moderator
    >
    > Registered: Apr 2001
    > Location: Arlington, Massachusetts
    > Occupation: Chemist (Drug Discovery at Genzyme)
    > Posts: 15282
    >
    >
    >
    > Publications
    >
    >
    > ISSUED UNITED STATES PATENTS
    >
    >
    > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;

    Mandeville, III; W. Harry.
    > US 6,566,407; 5/20/2003
    >
    > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall;

    Huval, Chad
    > Cori.
    > U.S. 6,517,825; 2/11/2003.
    >
    > 3. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley,
    > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.

    6,509,013; 1/21/2003.
    >
    > 4. Combination therapy for treating hypercholesterolemia using a bile acid

    sequestrant
    > polymer
    > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen

    Randall;
    > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    >
    > 5. Method for treating hypercholesterolemia with polyallylamine polymers.

    Holmes-Farley,
    > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg,

    Dennis I. , US
    > 6,423,754; 7/23/2002.
    >
    > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;

    Neenan, Thomas X..;
    > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    >
    > 7. Combination therapy for treating hypercholesterolemia and

    atherosclerosis. Huval, Chad
    > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K.

    U.S. 6,365,186;
    > 4/2/2002.
    >
    > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville,

    W. H., III;
    > Huval; C.
    > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;

    10/9/2001.
    >
    > 9. Polymers containing guanidinium groups as bile acid sequestrants. Dhal;

    P. K.; Holmes-
    > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    >
    > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,281,252;
    > 8/28/2001.
    >
    > 11. Combination therapy for treating hypercholestrolemia. Huval; C. C.;

    Holmes-Farley; S.
    > R. ;
    > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    >
    > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;

    Holmes-Farley, S.
    > R.; US
    > 6,264,937; 7/24/2001.
    >
    > 13. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,248,318;
    > 6/19/2001.
    >
    > 14. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    >
    > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.;

    Dhal, P. K.;
    > Petersen,
    > J. S.; US 6,203,785; 3/20/2001.
    >
    > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval,

    C. C.; US
    > 6,190,649;
    > 2/20/2001.
    >
    > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,177,478;
    > 1/23/2001.
    >
    > 18. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley,

    S. R.;
    > Mandeville, W.
    > H., III.; US 6,129,910; 10/10/2000.
    >
    > 19. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,083,497;
    > 7/4/2000.
    >
    > 20. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley, S.
    > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.
    >
    > 21. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.
    >
    > 22. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    >
    > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;

    Neenan; T. X.; Holmes-
    > Farley; S. R. US 6,034,129; 3/7/2000.
    >
    > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 5,985,938;
    > 11/16/99.
    >
    > 25. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    >
    > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H.,

    III.;
    > Holmes-Farley;
    > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    >
    > 27. Hydrophilic nonamine-containing and amine-containing copolymers and

    their use as bile
    > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184;

    7/27/99.
    >
    > 28. Interpenetrating polymer networks for sequestration of bile acids.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;

    7/20/99.
    >
    > 29. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    >
    > 30. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    >
    > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    >
    > 32. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    >
    > 33. Preparation of polymeric sequestrants for bile acid salts. Mandeville,

    W. H., III.;
    > Holmes-
    > Farley, S. R.; US 5,703,188; 12/30/97.
    >
    > 34. Oral administration of iron-binding crosslinked amine polymers.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    >
    > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S.

    R.; US 5,693,675;
    > 12/2/97.
    >
    > 36. Method for removing bile salts from a patient with alkylated

    crosslinked amine
    > polymers,
    > and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley,

    S. R.; US
    > 5,679,717; 10/21/97.
    >
    > 37. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,667,775; 9/16/97.
    >
    > 38. Ion-exchange process using highly crosslinked polymers for removing

    bile salts from a
    > patient, preparation of the polymers, and compositions containing them.

    Mandeville, W. H.,
    > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    >
    > 39. Hydrophobic amine polymer sequestrant and method of cholesterol

    depletion. Mandeville,
    > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.
    >
    > 40. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    >
    > 41. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,496,545; 3/5/96.
    >
    > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,

    III.; Holmes-Farley,
    > S. R.;
    > US 5,487,888; 1/30/96.
    >
    > 43. Ultra-thin, uniform sol-gel coating of a substrate having active

    hydrogens on the
    > surface.
    > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    >
    > 44. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley,

    S. R.; Yanyo, L.
    > C.;
    > US 5,182,143; 1/26/93.
    >
    > 45. Method for metal bonding using ultrathin primer coating.

    Holmes-Farley, S. R.; Yanyo,
    > L.
    > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    >
    > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US

    5,096,962;
    > 3/17/92.
    >
    > 47. Modified halogenatedpolyolefin adhesives for polyolefin

    elastomer-metal bonding.
    > Holmes-
    > Farley, S. R.; US 5,102,956; 4/7/92.
    >
    >
    >
    > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    >
    >
    > 1. Aryl boronate functionalized polymers for treating obesity and

    inhibiting fat uptake.
    > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal, Pradeep

    K.; Huval, Chad
    > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92 pp. WO

    0302571.
    >
    > 2. Preparation of aryl boronic acids for treating obesity. Holmes-Farley,

    Stephen Randall;
    > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep K.

    (Geltex
    > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    >
    > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,

    Stephen Randall.
    > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO

    0302130.
    >
    > 4. Method for reducing copper levels and treating copper toxicosis.

    Holmes-Farley, Stephen
    > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45

    pp. WO
    > 0285383.
    >
    > 5. Method for treating gout and binding uric acid. Holmes-Farley, Stephen

    Randall; Burke,
    > Steven K. WO 0285381 10/31/2002.
    >
    > 6. Method for treating gout and reducing serum uric acid. Holmes-Farley,

    Stephen Randall;
    > Burke, Steven K WO 0285380 10/31/2002.
    >
    > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;

    Holmes-Farley, S. R.;
    > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    >
    > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 1999-US5662; 9/23/1999.
    >
    > 9. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley,

    S. R.; Petersen,
    > J. S.;
    > WO 9933452; 7/8/1999.
    >
    > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 9922743; 5/14/1999.
    >
    > 11. Polyallylamine polymers for removing bile salts and treating

    hypercholesterolemia, and
    > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke,

    S. K.; Goldberg,
    > D. I.; WO 9857652; 12/23/98.
    >
    > 12. Phosphate-bidning polymers combined with a calcium supplement for oral

    administration.
    > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S.

    R.; WO 9842355;
    > 10/1/98.
    >
    > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol

    depletion. Mandeville,
    > W.
    > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    >
    > 14. Process for adjusting ion concentration in a patient and compositions

    therefor.
    > Mandeville,
    > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    >
    > 15. Vacuum-deposited silver on polycarbonate with a chromium interlayer

    for improved
    > metal-
    > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.
    >
    > 16. Process for increased metal-substrate bond strength in metalized

    plastics.
    > Holmes-Farley, S.
    > R.; Ger. Offen. 4322516; 7/6/93.
    >
    > 17. Electrorheological fluids and preparation of particles useful in the

    fluids.
    > Troughton,
    > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.

    David; Bares, Joseph
    > E.;
    > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP

    394049;
    > 10/24/1990.
    >
    > JOURNAL PUBLICATIONS
    >
    > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene;

    Guo, Amy;
    > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;

    Mandeville, W. Harry;
    > Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.
    >
    > 2. Amine functionalized polyethers as bile acid sequestrants: synthesis

    and biological
    > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall;

    Mandeville, W.
    > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.

    Journal of
    > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),

    1559-1574.
    >
    > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular

    Imprinting. Huval,
    > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.

    Randall; Mandeville,
    > W.
    > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.;

    Chen, Xi; Dhal,
    > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    >
    > 4. Synthetic polymers for the binding of fat in the intestinal tract.

    Jozefiak, Thomas H.;
    > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval,

    Chad C.;
    > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.

    Abstracts of
    > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August

    26-30, 2001
    > (2001), POLY-047 and Polymer Preprints (American Chemical Society,

    Division of
    > Polymer Chemistry) (2001), 42(2), 98.
    >
    > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel

    pharmaceutical.
    > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward,

    J.; Sacchiero,
    > B.;
    > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen,

    X.; Mazzeo, J.
    > R.. Polym. Preprints (2000), 41(1), 735-736.
    >
    > 6. In vitro comparison of bile acid binding to colesevelam HCl and other

    bile acid
    > sequestrants.
    > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;

    Hook, P.; Holmes-
    > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    >
    > 7. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley,

    S. R; Polym.
    > Mater. Sci. Eng (1999), 80, 246-247.
    >
    > 8. Design and characterization of of Sevelamer Hydrochloride: a novel

    phosphate-binding
    > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.;

    Miller, K. L.;
    > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and

    Appl. Chem.,
    > A36(7&8), p. 1085 (1999).
    >
    > 9. Three generations of bile acid sequestrants. Mandeville, W. H., III;

    Braunlin, W.;
    > Dhal, P.;
    > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;

    Rosenbaum, D.;
    > Sacchiero,
    > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),

    550, 3-15.
    >
    > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate

    binder, on
    > urinary
    > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;

    Mandeville, W. H.,
    > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.

    (1997), 12(5)
    > 961-964.
    >
    > 11. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley,

    S. R.; Yanyo, L.
    > C;
    > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.
    >
    > 12. The mechanism of cure initiation of a surface activated adhesive.

    Holmes-Farley, S.
    > R.;
    > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    >
    > 13. Adhesion promotion and corrosion prevention using thin anisotropic

    coatings. Holmes-
    > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),

    131-151.
    >
    > 14. Wetting of functionalized polyethylene having ionizable organic acids

    and bases at the
    > polymer-water interface: relations between functional group polarity,

    extent of
    > ionization,
    > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;

    Whitesides, G. M.;
    > Langmuir
    > (1988), 4(4), 921-937.
    >
    > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a

    single hydroxy group.
    > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    >
    > 16. Reconstruction of the interface of oxidatively functionalized

    polyethylene (PE-CO2H)
    > and
    > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.;

    McCarthy, T. J.;
    > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987),

    AD-
    > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    >
    > 17. Surface-modified polyethylene film: the relationship between surface

    chemistry and
    > physical
    > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.
    >
    > 18. Reactivity of carboxylic acid and ester groups in the functionalized

    interfacial
    > region of
    > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:

    differentiation of the
    > functional groups into shallow and deep subsets based on a comparison of

    contact angle and
    > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir

    (1987), 3(1), 62-
    > 76.
    >
    > 19. Fluorescence properties of dansyl groups covalently bonded tot he

    surface of
    > oxidatively
    > functionalized low-density polyethylene film. Holmes-Farley, S. R.;

    Whitesides, G. M.;
    > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;

    AD-A162435/2/GAR,
    > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    >
    > 20. Acid-base behavior of carboxylic acid groups covalently attached at

    the surface of
    > polyethylene: The usefulness of contact angle in following the ionization

    of surface
    > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;

    Deutch, J.;
    > Whitesides,
    > G. M.; Langmuir (1985), 1(6), 725-740.
    >
    > 21. The thermal stability of a surface modified solid organic polymer.

    Holmes-Farley, S.
    > R.;
    > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    >
    >
    >
    > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    >
    > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced

    Aquarist. June 2003.
    >
    > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.

    Advanced Aquarist.
    > May
    > 2003.
    >
    > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.

    Reefkeeping May
    > 2003.
    >
    > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping

    April 2003.
    >
    > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced Aquarist;

    March 2003.
    >
    > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.

    Holmes-Farley, R.
    > Advanced Aquarist; February 2003.
    >
    > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January

    2003.
    >
    > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; December

    2002.
    >
    > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R. Advanced

    Aquarist; November
    > 2002.
    >
    > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.

    Advanced Aquarist;
    > November 2002.
    >
    > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced Aquarist,

    September 2002.
    >
    > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August

    2002.
    >
    > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April

    2002.
    >
    > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced

    Aquarist; July 2002
    >
    > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist; June

    2002.
    >
    > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R. Advanced

    Aquarist, May
    > 2002.
    >
    > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.

    Holmes-Farley, R.
    > Advanced Aquarist, April 2002.
    >
    > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    >
    > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    >
    > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January 2002.
    >
    > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium

    Frontiers 2000.
    >
    > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.

    Aquarium Frontiers
    > 2000.
    > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers 2000.
    >
    > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    >
    > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    >
    >
    >
    >
    >
    >
    >
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    >
    >
     
    stoutman, Feb 10, 2004
    #44
  5. Dinky

    stoutman Guest

    Boomer, here is another link.

    http://bcn.boulder.co.us/basin/data/NUTRIENTS/info/Alk.html



    So I guess everyone is wrong but you, right?






    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102ht0bjplpo059@corp.supernews.com...
    > Now I am getting bored
    >
    > "Don't the components of a buffer account for the buffering capacity?

    Yes."
    >
    > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity and

    Alkalinity are
    > not the same, that has always been the issue. I gave the equation does

    that look like an
    > Alkalinity equation or how Alk is determined. I see you had now comments

    on it what's
    > wrong, why no comments on the equations I gave. Don't understand them or

    what ? Again this
    > is the equation for Buffering Capacity, also called Buffer Index or Buffer

    Intensity. It
    > is defined in most water chemistry and chemical oceanography text books.
    >
    > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa

    [H3O+] / (Ka =
    > H3O+])² )
    >
    > This is not Alkalinity now is it ?
    >
    > "I know how to do a titration, In fact I have done several. How many have
    > you actually done? I don't mean by counting drops, I mean with a buret?"
    >
    > Well good for you, I use a Digital Titrator
    >
    > "Oh, I see,
    > you think acidity is the opposite of alkalinity. In the world of

    CHEMISTRY
    > it's not. Maybe in aquarium newsgroups it is.
    >
    > Hum no, maybe you should go for a look at HACH's or LaMotte website or the

    book I
    > suggested earlier. Please view a copy.
    >
    > Standard Methods for the Examination of Water and Wastewater
    >
    > This book, over 2000 pages, is the guide for water testing. If you are

    reporting water
    > test to the EPA you must use approved std from this text.I t is prepared

    and published by
    > the EPA, American Water Works Association and American Public Health

    Association. You
    > mean you don't have one and the issue is water chemistry
    >
    > You are confusing Acidity and Acidity as you know little about water

    chemistry and
    > procedures and test methods
    >
    > From SMEWW, section 2-30, 2310 ACIDITY
    >
    > "Acidity of water is its quantative capacity to react with a strong base

    to a designated
    > pH"
    >
    > This is how you test for it
    >
    > A std alkali titration to methyl orange or phenolphthalein
    > endpoint.
    >
    > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this

    book, there are
    > over 100 of them, they are wrong.
    >
    > Like Buffering Capacity you have your Acidity's mixed up
    > In water measurement if you have a high Alk you also usually have a high

    Acidity.
    > Normally a high Alk also gives a higher CO2 level. Get a WATER CHEMISTRY

    BOOK there pal.
    >
    >
    > "These are all in equilibrium with each other. An initial high pH (above
    > 6.4) will shift the equilibrium to the right to form HCO3-1. If the pH of
    > the solution is above 10.3 (pKa2) the .........."
    >
    >
    > Christ, there you go again with the FW shit. All your numbers are wrong we

    are dealing
    > with SEAWATER
    >
    > This means that at a pH of 8.3, the majority of the CO2(aq) is in the form
    > of HCO3-1 .
    >
    > I have already pointed that out and gave actual values at know seawater

    levels, go back
    > and re-read it you aren't telling me anything here.Of course most is HCO3

    see...
    >
    >
    > @ 20C and 34.3 ppt salinity
    >
    > CO2 = 0.52 %
    >
    > HCO3 = 86.4 %
    >
    > CO3 = 13.09 %
    >
    >
    > "In your glass experiment you managed to lower the pH enough to purge out

    CO2
    > by boiling"
    >
    > The purpose behind the glass is to show that alk is not affect by CO2 and

    vise-versa and
    > how Co2 affects pH.
    >
    > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH drops

    to say 8.1 it is
    > usually due to excess CO2. If you took a glass of that water and aerated

    it you WILL drive
    > off the CO2 and raise the pH. It has been done a proven a million times.
    >
    > "In order to 'purge' CO2 you would need to lower the
    > pH to shift the equilibrium to below 6.4"
    >
    > The hell you do !!!.Do you know who many times people on this NG to

    include Dr. Craig
    > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a

    sample of aquarium
    > water and aerate it to see if the pH GOES UP AND when they come back with

    the test it is
    > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST excess

    CO2 in the tank
    > water, increase the circulation for better gas exchange at the surface,

    reduce feeding,
    > and try to improve on better skimming, thus reducing the bio-load and pH

    decline due to
    > CO2.
    >
    >
    > "I hope this helps. "
    >
    > Help, how can you when you miss everything. I should be charging you
    >
    > Oh, by the way. Your websites, I have about 50 on these issues, I could

    post them, not to
    > mention I have all those water chemistry books, so there is no need to

    view your sites.
    >
    > Finally are you afraid to come to our Chemistry Forum, afraid to get

    slapped by REAL
    > chemists. I get a charge out of you can't post your ref .I have posted the

    same or similar
    > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts

    there and am the
    > biggest contributor to his forum other than himself or maybe Habib Sheka
    >
    > Hum, here are Randy's ref that he posted. He hosts the website
    >
    > S. RANDY HOLMES-FARLEY
    > Arlington, Massachusetts
    >
    > EDUCATION
    >
    > 1982-1986 Harvard University Cambridge, MA
    > PhD in Chemistry
    > Research Advisor: George Whitesides
    >
    > Investigated the relationship between polymer surface chemistry and

    physical properties
    > through controlled surface modification and testing.
    >
    > 1980-1982 Cornell University Ithaca, NY
    > BA in Chemistry and Biology
    > Graduated Summa Cum Laude
    > Distinction in All Subjects
    > Grade Point: 3.94/4.0
    > Honors research: isolation and characterization of the subunit of CF1

    enzyme
    >
    >
    > 1978-1979 Stanford University Palo Alto, CA
    > Grade Point: 3.55/4.0
    >
    >
    > EXPERIENCE
    >
    > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > (bought out GelTex Pharmaceuticals in 2001)
    > Vice President, Chemical Research 2001-present
    > Senior Director, Chemical Research 1999-2001
    > Director of Chemical Research 1997-1999
    > Manager of Chemical Research 1995-1997
    > Group Leader 1994-1995
    > Senior Research Scientist 1992-1994
    >
    > Helped start GelTex as second employee
    >
    > Managed various research programs with multi-million dollar budgets
    >
    > Supervised research chemists (17+)
    >
    > Co-inventor of several polymeric pharmaceuticals and pharmaceutical

    candidates including
    > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride (FDA

    approved)
    >
    > Company Safety Officer for 3 years
    >
    > Chemical Hygiene Officer 2000-present
    >
    >
    >
    >
    > 1990-1992 GTE Corporation Waltham, MA
    > Senior Member of Technical Staff
    > Applied research involving polymer interfaces
    > Metallization of plastics
    > Polymer/polymer adhesion
    > Optical coatings
    >
    >
    >
    > 1986-1990 Lord Corporation Cary, NC
    > Senior Research Scientist 1988-1990
    > Research Scientist 1986-1988
    > Basic and applied research on surface chemical bonding
    > Developed new adhesive compositions
    > Developed new sol-gel coatings for corrosion resistance
    >
    >
    > HONORS AND AWARDS
    >
    > Industrial Innovations Award by Northeast Region of American Chemical

    Society (6/2001)
    >
    > National Kidney Foundation of Northern California Honoree (5/2001)
    >
    > American Chemical Society/Polymer Chemistry Division Industrial Sponsors
    > Award (8/2000)
    >
    > R&D 100 Award from R&D magazine (1999)
    >
    > Sherwin Williams Award in applied polymer science (9/85)
    >
    > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    >
    > Award for highest GPA in Chemistry Department (6/82)
    >
    > Summa Cum Laude Honors in Chemistry (6/82)
    >
    > Phi Lamda Epsilon (6/82)
    >
    > Phi Beta Kappa (2/82)
    >
    > Cornell University Dean's List (1981, 1982)
    >
    > Harvard Book Club Award for highest GPA senior year (1978)
    >
    > First Place in western NY ACS high school chemistry exam (1977)
    >
    > 1978-1979
    >
    >
    > __________________
    > Randy Holmes-Farley
    > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    >
    > Hobby Experience: 8 years with reefs
    > Current Tanks: 90 gal mixed reef
    > Interests: Reefkeeping, science, photography
    >
    >
    > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    >
    > Open this post in a new window | Report this post to a moderator | IP:

    Logged
    >
    >
    >
    > 06/27/2003 02:44 PM
    >
    > Randy Holmes-Farley
    > Chemistry Moderator
    >
    > Registered: Apr 2001
    > Location: Arlington, Massachusetts
    > Occupation: Chemist (Drug Discovery at Genzyme)
    > Posts: 15282
    >
    >
    >
    > Publications
    >
    >
    > ISSUED UNITED STATES PATENTS
    >
    >
    > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;

    Mandeville, III; W. Harry.
    > US 6,566,407; 5/20/2003
    >
    > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall;

    Huval, Chad
    > Cori.
    > U.S. 6,517,825; 2/11/2003.
    >
    > 3. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley,
    > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.

    6,509,013; 1/21/2003.
    >
    > 4. Combination therapy for treating hypercholesterolemia using a bile acid

    sequestrant
    > polymer
    > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen

    Randall;
    > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    >
    > 5. Method for treating hypercholesterolemia with polyallylamine polymers.

    Holmes-Farley,
    > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg,

    Dennis I. , US
    > 6,423,754; 7/23/2002.
    >
    > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;

    Neenan, Thomas X..;
    > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    >
    > 7. Combination therapy for treating hypercholesterolemia and

    atherosclerosis. Huval, Chad
    > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K.

    U.S. 6,365,186;
    > 4/2/2002.
    >
    > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville,

    W. H., III;
    > Huval; C.
    > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;

    10/9/2001.
    >
    > 9. Polymers containing guanidinium groups as bile acid sequestrants. Dhal;

    P. K.; Holmes-
    > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    >
    > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,281,252;
    > 8/28/2001.
    >
    > 11. Combination therapy for treating hypercholestrolemia. Huval; C. C.;

    Holmes-Farley; S.
    > R. ;
    > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    >
    > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;

    Holmes-Farley, S.
    > R.; US
    > 6,264,937; 7/24/2001.
    >
    > 13. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,248,318;
    > 6/19/2001.
    >
    > 14. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    >
    > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.;

    Dhal, P. K.;
    > Petersen,
    > J. S.; US 6,203,785; 3/20/2001.
    >
    > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval,

    C. C.; US
    > 6,190,649;
    > 2/20/2001.
    >
    > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,177,478;
    > 1/23/2001.
    >
    > 18. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley,

    S. R.;
    > Mandeville, W.
    > H., III.; US 6,129,910; 10/10/2000.
    >
    > 19. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,083,497;
    > 7/4/2000.
    >
    > 20. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley, S.
    > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.
    >
    > 21. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.
    >
    > 22. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    >
    > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;

    Neenan; T. X.; Holmes-
    > Farley; S. R. US 6,034,129; 3/7/2000.
    >
    > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 5,985,938;
    > 11/16/99.
    >
    > 25. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    >
    > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H.,

    III.;
    > Holmes-Farley;
    > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    >
    > 27. Hydrophilic nonamine-containing and amine-containing copolymers and

    their use as bile
    > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184;

    7/27/99.
    >
    > 28. Interpenetrating polymer networks for sequestration of bile acids.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;

    7/20/99.
    >
    > 29. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    >
    > 30. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    >
    > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    >
    > 32. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    >
    > 33. Preparation of polymeric sequestrants for bile acid salts. Mandeville,

    W. H., III.;
    > Holmes-
    > Farley, S. R.; US 5,703,188; 12/30/97.
    >
    > 34. Oral administration of iron-binding crosslinked amine polymers.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    >
    > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S.

    R.; US 5,693,675;
    > 12/2/97.
    >
    > 36. Method for removing bile salts from a patient with alkylated

    crosslinked amine
    > polymers,
    > and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley,

    S. R.; US
    > 5,679,717; 10/21/97.
    >
    > 37. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,667,775; 9/16/97.
    >
    > 38. Ion-exchange process using highly crosslinked polymers for removing

    bile salts from a
    > patient, preparation of the polymers, and compositions containing them.

    Mandeville, W. H.,
    > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    >
    > 39. Hydrophobic amine polymer sequestrant and method of cholesterol

    depletion. Mandeville,
    > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.
    >
    > 40. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    >
    > 41. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,496,545; 3/5/96.
    >
    > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,

    III.; Holmes-Farley,
    > S. R.;
    > US 5,487,888; 1/30/96.
    >
    > 43. Ultra-thin, uniform sol-gel coating of a substrate having active

    hydrogens on the
    > surface.
    > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    >
    > 44. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley,

    S. R.; Yanyo, L.
    > C.;
    > US 5,182,143; 1/26/93.
    >
    > 45. Method for metal bonding using ultrathin primer coating.

    Holmes-Farley, S. R.; Yanyo,
    > L.
    > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    >
    > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US

    5,096,962;
    > 3/17/92.
    >
    > 47. Modified halogenatedpolyolefin adhesives for polyolefin

    elastomer-metal bonding.
    > Holmes-
    > Farley, S. R.; US 5,102,956; 4/7/92.
    >
    >
    >
    > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    >
    >
    > 1. Aryl boronate functionalized polymers for treating obesity and

    inhibiting fat uptake.
    > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal, Pradeep

    K.; Huval, Chad
    > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92 pp. WO

    0302571.
    >
    > 2. Preparation of aryl boronic acids for treating obesity. Holmes-Farley,

    Stephen Randall;
    > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep K.

    (Geltex
    > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    >
    > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,

    Stephen Randall.
    > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO

    0302130.
    >
    > 4. Method for reducing copper levels and treating copper toxicosis.

    Holmes-Farley, Stephen
    > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45

    pp. WO
    > 0285383.
    >
    > 5. Method for treating gout and binding uric acid. Holmes-Farley, Stephen

    Randall; Burke,
    > Steven K. WO 0285381 10/31/2002.
    >
    > 6. Method for treating gout and reducing serum uric acid. Holmes-Farley,

    Stephen Randall;
    > Burke, Steven K WO 0285380 10/31/2002.
    >
    > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;

    Holmes-Farley, S. R.;
    > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    >
    > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 1999-US5662; 9/23/1999.
    >
    > 9. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley,

    S. R.; Petersen,
    > J. S.;
    > WO 9933452; 7/8/1999.
    >
    > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 9922743; 5/14/1999.
    >
    > 11. Polyallylamine polymers for removing bile salts and treating

    hypercholesterolemia, and
    > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke,

    S. K.; Goldberg,
    > D. I.; WO 9857652; 12/23/98.
    >
    > 12. Phosphate-bidning polymers combined with a calcium supplement for oral

    administration.
    > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S.

    R.; WO 9842355;
    > 10/1/98.
    >
    > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol

    depletion. Mandeville,
    > W.
    > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    >
    > 14. Process for adjusting ion concentration in a patient and compositions

    therefor.
    > Mandeville,
    > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    >
    > 15. Vacuum-deposited silver on polycarbonate with a chromium interlayer

    for improved
    > metal-
    > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.
    >
    > 16. Process for increased metal-substrate bond strength in metalized

    plastics.
    > Holmes-Farley, S.
    > R.; Ger. Offen. 4322516; 7/6/93.
    >
    > 17. Electrorheological fluids and preparation of particles useful in the

    fluids.
    > Troughton,
    > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.

    David; Bares, Joseph
    > E.;
    > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP

    394049;
    > 10/24/1990.
    >
    > JOURNAL PUBLICATIONS
    >
    > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene;

    Guo, Amy;
    > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;

    Mandeville, W. Harry;
    > Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.
    >
    > 2. Amine functionalized polyethers as bile acid sequestrants: synthesis

    and biological
    > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall;

    Mandeville, W.
    > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.

    Journal of
    > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),

    1559-1574.
    >
    > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular

    Imprinting. Huval,
    > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.

    Randall; Mandeville,
    > W.
    > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.;

    Chen, Xi; Dhal,
    > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    >
    > 4. Synthetic polymers for the binding of fat in the intestinal tract.

    Jozefiak, Thomas H.;
    > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval,

    Chad C.;
    > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.

    Abstracts of
    > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August

    26-30, 2001
    > (2001), POLY-047 and Polymer Preprints (American Chemical Society,

    Division of
    > Polymer Chemistry) (2001), 42(2), 98.
    >
    > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel

    pharmaceutical.
    > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward,

    J.; Sacchiero,
    > B.;
    > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen,

    X.; Mazzeo, J.
    > R.. Polym. Preprints (2000), 41(1), 735-736.
    >
    > 6. In vitro comparison of bile acid binding to colesevelam HCl and other

    bile acid
    > sequestrants.
    > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;

    Hook, P.; Holmes-
    > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    >
    > 7. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley,

    S. R; Polym.
    > Mater. Sci. Eng (1999), 80, 246-247.
    >
    > 8. Design and characterization of of Sevelamer Hydrochloride: a novel

    phosphate-binding
    > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.;

    Miller, K. L.;
    > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and

    Appl. Chem.,
    > A36(7&8), p. 1085 (1999).
    >
    > 9. Three generations of bile acid sequestrants. Mandeville, W. H., III;

    Braunlin, W.;
    > Dhal, P.;
    > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;

    Rosenbaum, D.;
    > Sacchiero,
    > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),

    550, 3-15.
    >
    > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate

    binder, on
    > urinary
    > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;

    Mandeville, W. H.,
    > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.

    (1997), 12(5)
    > 961-964.
    >
    > 11. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley,

    S. R.; Yanyo, L.
    > C;
    > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.
    >
    > 12. The mechanism of cure initiation of a surface activated adhesive.

    Holmes-Farley, S.
    > R.;
    > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    >
    > 13. Adhesion promotion and corrosion prevention using thin anisotropic

    coatings. Holmes-
    > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),

    131-151.
    >
    > 14. Wetting of functionalized polyethylene having ionizable organic acids

    and bases at the
    > polymer-water interface: relations between functional group polarity,

    extent of
    > ionization,
    > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;

    Whitesides, G. M.;
    > Langmuir
    > (1988), 4(4), 921-937.
    >
    > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a

    single hydroxy group.
    > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    >
    > 16. Reconstruction of the interface of oxidatively functionalized

    polyethylene (PE-CO2H)
    > and
    > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.;

    McCarthy, T. J.;
    > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987),

    AD-
    > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    >
    > 17. Surface-modified polyethylene film: the relationship between surface

    chemistry and
    > physical
    > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.
    >
    > 18. Reactivity of carboxylic acid and ester groups in the functionalized

    interfacial
    > region of
    > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:

    differentiation of the
    > functional groups into shallow and deep subsets based on a comparison of

    contact angle and
    > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir

    (1987), 3(1), 62-
    > 76.
    >
    > 19. Fluorescence properties of dansyl groups covalently bonded tot he

    surface of
    > oxidatively
    > functionalized low-density polyethylene film. Holmes-Farley, S. R.;

    Whitesides, G. M.;
    > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;

    AD-A162435/2/GAR,
    > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    >
    > 20. Acid-base behavior of carboxylic acid groups covalently attached at

    the surface of
    > polyethylene: The usefulness of contact angle in following the ionization

    of surface
    > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;

    Deutch, J.;
    > Whitesides,
    > G. M.; Langmuir (1985), 1(6), 725-740.
    >
    > 21. The thermal stability of a surface modified solid organic polymer.

    Holmes-Farley, S.
    > R.;
    > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    >
    >
    >
    > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    >
    > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced

    Aquarist. June 2003.
    >
    > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.

    Advanced Aquarist.
    > May
    > 2003.
    >
    > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.

    Reefkeeping May
    > 2003.
    >
    > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping

    April 2003.
    >
    > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced Aquarist;

    March 2003.
    >
    > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.

    Holmes-Farley, R.
    > Advanced Aquarist; February 2003.
    >
    > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January

    2003.
    >
    > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; December

    2002.
    >
    > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R. Advanced

    Aquarist; November
    > 2002.
    >
    > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.

    Advanced Aquarist;
    > November 2002.
    >
    > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced Aquarist,

    September 2002.
    >
    > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August

    2002.
    >
    > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April

    2002.
    >
    > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced

    Aquarist; July 2002
    >
    > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist; June

    2002.
    >
    > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R. Advanced

    Aquarist, May
    > 2002.
    >
    > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.

    Holmes-Farley, R.
    > Advanced Aquarist, April 2002.
    >
    > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    >
    > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    >
    > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January 2002.
    >
    > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium

    Frontiers 2000.
    >
    > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.

    Aquarium Frontiers
    > 2000.
    > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers 2000.
    >
    > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    >
    > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    >
    >
    >
    >
    >
    >
    >
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    >
    >
     
    stoutman, Feb 10, 2004
    #45
  6. Dinky

    stoutman Guest

    Man here is another, google is a wonderful thing. I'm not filtering any
    out, just posting what I find by GOOGLING for you.

    http://www.globe.gov/hq/trr_suppl/hydro/HY_SUP_ALK_INTRO_NOTES.HTML


    Wow, a gov link. Even the government is wrong, this must be a conspiracy
    against Boomer.




    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102ht0bjplpo059@corp.supernews.com...
    > Now I am getting bored
    >
    > "Don't the components of a buffer account for the buffering capacity?

    Yes."
    >
    > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity and

    Alkalinity are
    > not the same, that has always been the issue. I gave the equation does

    that look like an
    > Alkalinity equation or how Alk is determined. I see you had now comments

    on it what's
    > wrong, why no comments on the equations I gave. Don't understand them or

    what ? Again this
    > is the equation for Buffering Capacity, also called Buffer Index or Buffer

    Intensity. It
    > is defined in most water chemistry and chemical oceanography text books.
    >
    > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa

    [H3O+] / (Ka =
    > H3O+])² )
    >
    > This is not Alkalinity now is it ?
    >
    > "I know how to do a titration, In fact I have done several. How many have
    > you actually done? I don't mean by counting drops, I mean with a buret?"
    >
    > Well good for you, I use a Digital Titrator
    >
    > "Oh, I see,
    > you think acidity is the opposite of alkalinity. In the world of

    CHEMISTRY
    > it's not. Maybe in aquarium newsgroups it is.
    >
    > Hum no, maybe you should go for a look at HACH's or LaMotte website or the

    book I
    > suggested earlier. Please view a copy.
    >
    > Standard Methods for the Examination of Water and Wastewater
    >
    > This book, over 2000 pages, is the guide for water testing. If you are

    reporting water
    > test to the EPA you must use approved std from this text.I t is prepared

    and published by
    > the EPA, American Water Works Association and American Public Health

    Association. You
    > mean you don't have one and the issue is water chemistry
    >
    > You are confusing Acidity and Acidity as you know little about water

    chemistry and
    > procedures and test methods
    >
    > From SMEWW, section 2-30, 2310 ACIDITY
    >
    > "Acidity of water is its quantative capacity to react with a strong base

    to a designated
    > pH"
    >
    > This is how you test for it
    >
    > A std alkali titration to methyl orange or phenolphthalein
    > endpoint.
    >
    > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this

    book, there are
    > over 100 of them, they are wrong.
    >
    > Like Buffering Capacity you have your Acidity's mixed up
    > In water measurement if you have a high Alk you also usually have a high

    Acidity.
    > Normally a high Alk also gives a higher CO2 level. Get a WATER CHEMISTRY

    BOOK there pal.
    >
    >
    > "These are all in equilibrium with each other. An initial high pH (above
    > 6.4) will shift the equilibrium to the right to form HCO3-1. If the pH of
    > the solution is above 10.3 (pKa2) the .........."
    >
    >
    > Christ, there you go again with the FW shit. All your numbers are wrong we

    are dealing
    > with SEAWATER
    >
    > This means that at a pH of 8.3, the majority of the CO2(aq) is in the form
    > of HCO3-1 .
    >
    > I have already pointed that out and gave actual values at know seawater

    levels, go back
    > and re-read it you aren't telling me anything here.Of course most is HCO3

    see...
    >
    >
    > @ 20C and 34.3 ppt salinity
    >
    > CO2 = 0.52 %
    >
    > HCO3 = 86.4 %
    >
    > CO3 = 13.09 %
    >
    >
    > "In your glass experiment you managed to lower the pH enough to purge out

    CO2
    > by boiling"
    >
    > The purpose behind the glass is to show that alk is not affect by CO2 and

    vise-versa and
    > how Co2 affects pH.
    >
    > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH drops

    to say 8.1 it is
    > usually due to excess CO2. If you took a glass of that water and aerated

    it you WILL drive
    > off the CO2 and raise the pH. It has been done a proven a million times.
    >
    > "In order to 'purge' CO2 you would need to lower the
    > pH to shift the equilibrium to below 6.4"
    >
    > The hell you do !!!.Do you know who many times people on this NG to

    include Dr. Craig
    > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a

    sample of aquarium
    > water and aerate it to see if the pH GOES UP AND when they come back with

    the test it is
    > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST excess

    CO2 in the tank
    > water, increase the circulation for better gas exchange at the surface,

    reduce feeding,
    > and try to improve on better skimming, thus reducing the bio-load and pH

    decline due to
    > CO2.
    >
    >
    > "I hope this helps. "
    >
    > Help, how can you when you miss everything. I should be charging you
    >
    > Oh, by the way. Your websites, I have about 50 on these issues, I could

    post them, not to
    > mention I have all those water chemistry books, so there is no need to

    view your sites.
    >
    > Finally are you afraid to come to our Chemistry Forum, afraid to get

    slapped by REAL
    > chemists. I get a charge out of you can't post your ref .I have posted the

    same or similar
    > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts

    there and am the
    > biggest contributor to his forum other than himself or maybe Habib Sheka
    >
    > Hum, here are Randy's ref that he posted. He hosts the website
    >
    > S. RANDY HOLMES-FARLEY
    > Arlington, Massachusetts
    >
    > EDUCATION
    >
    > 1982-1986 Harvard University Cambridge, MA
    > PhD in Chemistry
    > Research Advisor: George Whitesides
    >
    > Investigated the relationship between polymer surface chemistry and

    physical properties
    > through controlled surface modification and testing.
    >
    > 1980-1982 Cornell University Ithaca, NY
    > BA in Chemistry and Biology
    > Graduated Summa Cum Laude
    > Distinction in All Subjects
    > Grade Point: 3.94/4.0
    > Honors research: isolation and characterization of the subunit of CF1

    enzyme
    >
    >
    > 1978-1979 Stanford University Palo Alto, CA
    > Grade Point: 3.55/4.0
    >
    >
    > EXPERIENCE
    >
    > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > (bought out GelTex Pharmaceuticals in 2001)
    > Vice President, Chemical Research 2001-present
    > Senior Director, Chemical Research 1999-2001
    > Director of Chemical Research 1997-1999
    > Manager of Chemical Research 1995-1997
    > Group Leader 1994-1995
    > Senior Research Scientist 1992-1994
    >
    > Helped start GelTex as second employee
    >
    > Managed various research programs with multi-million dollar budgets
    >
    > Supervised research chemists (17+)
    >
    > Co-inventor of several polymeric pharmaceuticals and pharmaceutical

    candidates including
    > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride (FDA

    approved)
    >
    > Company Safety Officer for 3 years
    >
    > Chemical Hygiene Officer 2000-present
    >
    >
    >
    >
    > 1990-1992 GTE Corporation Waltham, MA
    > Senior Member of Technical Staff
    > Applied research involving polymer interfaces
    > Metallization of plastics
    > Polymer/polymer adhesion
    > Optical coatings
    >
    >
    >
    > 1986-1990 Lord Corporation Cary, NC
    > Senior Research Scientist 1988-1990
    > Research Scientist 1986-1988
    > Basic and applied research on surface chemical bonding
    > Developed new adhesive compositions
    > Developed new sol-gel coatings for corrosion resistance
    >
    >
    > HONORS AND AWARDS
    >
    > Industrial Innovations Award by Northeast Region of American Chemical

    Society (6/2001)
    >
    > National Kidney Foundation of Northern California Honoree (5/2001)
    >
    > American Chemical Society/Polymer Chemistry Division Industrial Sponsors
    > Award (8/2000)
    >
    > R&D 100 Award from R&D magazine (1999)
    >
    > Sherwin Williams Award in applied polymer science (9/85)
    >
    > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    >
    > Award for highest GPA in Chemistry Department (6/82)
    >
    > Summa Cum Laude Honors in Chemistry (6/82)
    >
    > Phi Lamda Epsilon (6/82)
    >
    > Phi Beta Kappa (2/82)
    >
    > Cornell University Dean's List (1981, 1982)
    >
    > Harvard Book Club Award for highest GPA senior year (1978)
    >
    > First Place in western NY ACS high school chemistry exam (1977)
    >
    > 1978-1979
    >
    >
    > __________________
    > Randy Holmes-Farley
    > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    >
    > Hobby Experience: 8 years with reefs
    > Current Tanks: 90 gal mixed reef
    > Interests: Reefkeeping, science, photography
    >
    >
    > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    >
    > Open this post in a new window | Report this post to a moderator | IP:

    Logged
    >
    >
    >
    > 06/27/2003 02:44 PM
    >
    > Randy Holmes-Farley
    > Chemistry Moderator
    >
    > Registered: Apr 2001
    > Location: Arlington, Massachusetts
    > Occupation: Chemist (Drug Discovery at Genzyme)
    > Posts: 15282
    >
    >
    >
    > Publications
    >
    >
    > ISSUED UNITED STATES PATENTS
    >
    >
    > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;

    Mandeville, III; W. Harry.
    > US 6,566,407; 5/20/2003
    >
    > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall;

    Huval, Chad
    > Cori.
    > U.S. 6,517,825; 2/11/2003.
    >
    > 3. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley,
    > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.

    6,509,013; 1/21/2003.
    >
    > 4. Combination therapy for treating hypercholesterolemia using a bile acid

    sequestrant
    > polymer
    > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen

    Randall;
    > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    >
    > 5. Method for treating hypercholesterolemia with polyallylamine polymers.

    Holmes-Farley,
    > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg,

    Dennis I. , US
    > 6,423,754; 7/23/2002.
    >
    > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;

    Neenan, Thomas X..;
    > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    >
    > 7. Combination therapy for treating hypercholesterolemia and

    atherosclerosis. Huval, Chad
    > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K.

    U.S. 6,365,186;
    > 4/2/2002.
    >
    > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville,

    W. H., III;
    > Huval; C.
    > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;

    10/9/2001.
    >
    > 9. Polymers containing guanidinium groups as bile acid sequestrants. Dhal;

    P. K.; Holmes-
    > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    >
    > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,281,252;
    > 8/28/2001.
    >
    > 11. Combination therapy for treating hypercholestrolemia. Huval; C. C.;

    Holmes-Farley; S.
    > R. ;
    > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    >
    > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;

    Holmes-Farley, S.
    > R.; US
    > 6,264,937; 7/24/2001.
    >
    > 13. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,248,318;
    > 6/19/2001.
    >
    > 14. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    >
    > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.;

    Dhal, P. K.;
    > Petersen,
    > J. S.; US 6,203,785; 3/20/2001.
    >
    > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval,

    C. C.; US
    > 6,190,649;
    > 2/20/2001.
    >
    > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,177,478;
    > 1/23/2001.
    >
    > 18. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley,

    S. R.;
    > Mandeville, W.
    > H., III.; US 6,129,910; 10/10/2000.
    >
    > 19. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,083,497;
    > 7/4/2000.
    >
    > 20. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley, S.
    > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.
    >
    > 21. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.
    >
    > 22. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    >
    > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;

    Neenan; T. X.; Holmes-
    > Farley; S. R. US 6,034,129; 3/7/2000.
    >
    > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 5,985,938;
    > 11/16/99.
    >
    > 25. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    >
    > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H.,

    III.;
    > Holmes-Farley;
    > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    >
    > 27. Hydrophilic nonamine-containing and amine-containing copolymers and

    their use as bile
    > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184;

    7/27/99.
    >
    > 28. Interpenetrating polymer networks for sequestration of bile acids.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;

    7/20/99.
    >
    > 29. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    >
    > 30. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    >
    > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    >
    > 32. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    >
    > 33. Preparation of polymeric sequestrants for bile acid salts. Mandeville,

    W. H., III.;
    > Holmes-
    > Farley, S. R.; US 5,703,188; 12/30/97.
    >
    > 34. Oral administration of iron-binding crosslinked amine polymers.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    >
    > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S.

    R.; US 5,693,675;
    > 12/2/97.
    >
    > 36. Method for removing bile salts from a patient with alkylated

    crosslinked amine
    > polymers,
    > and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley,

    S. R.; US
    > 5,679,717; 10/21/97.
    >
    > 37. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,667,775; 9/16/97.
    >
    > 38. Ion-exchange process using highly crosslinked polymers for removing

    bile salts from a
    > patient, preparation of the polymers, and compositions containing them.

    Mandeville, W. H.,
    > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    >
    > 39. Hydrophobic amine polymer sequestrant and method of cholesterol

    depletion. Mandeville,
    > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.
    >
    > 40. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    >
    > 41. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,496,545; 3/5/96.
    >
    > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,

    III.; Holmes-Farley,
    > S. R.;
    > US 5,487,888; 1/30/96.
    >
    > 43. Ultra-thin, uniform sol-gel coating of a substrate having active

    hydrogens on the
    > surface.
    > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    >
    > 44. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley,

    S. R.; Yanyo, L.
    > C.;
    > US 5,182,143; 1/26/93.
    >
    > 45. Method for metal bonding using ultrathin primer coating.

    Holmes-Farley, S. R.; Yanyo,
    > L.
    > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    >
    > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US

    5,096,962;
    > 3/17/92.
    >
    > 47. Modified halogenatedpolyolefin adhesives for polyolefin

    elastomer-metal bonding.
    > Holmes-
    > Farley, S. R.; US 5,102,956; 4/7/92.
    >
    >
    >
    > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    >
    >
    > 1. Aryl boronate functionalized polymers for treating obesity and

    inhibiting fat uptake.
    > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal, Pradeep

    K.; Huval, Chad
    > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92 pp. WO

    0302571.
    >
    > 2. Preparation of aryl boronic acids for treating obesity. Holmes-Farley,

    Stephen Randall;
    > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep K.

    (Geltex
    > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    >
    > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,

    Stephen Randall.
    > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO

    0302130.
    >
    > 4. Method for reducing copper levels and treating copper toxicosis.

    Holmes-Farley, Stephen
    > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45

    pp. WO
    > 0285383.
    >
    > 5. Method for treating gout and binding uric acid. Holmes-Farley, Stephen

    Randall; Burke,
    > Steven K. WO 0285381 10/31/2002.
    >
    > 6. Method for treating gout and reducing serum uric acid. Holmes-Farley,

    Stephen Randall;
    > Burke, Steven K WO 0285380 10/31/2002.
    >
    > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;

    Holmes-Farley, S. R.;
    > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    >
    > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 1999-US5662; 9/23/1999.
    >
    > 9. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley,

    S. R.; Petersen,
    > J. S.;
    > WO 9933452; 7/8/1999.
    >
    > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 9922743; 5/14/1999.
    >
    > 11. Polyallylamine polymers for removing bile salts and treating

    hypercholesterolemia, and
    > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke,

    S. K.; Goldberg,
    > D. I.; WO 9857652; 12/23/98.
    >
    > 12. Phosphate-bidning polymers combined with a calcium supplement for oral

    administration.
    > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S.

    R.; WO 9842355;
    > 10/1/98.
    >
    > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol

    depletion. Mandeville,
    > W.
    > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    >
    > 14. Process for adjusting ion concentration in a patient and compositions

    therefor.
    > Mandeville,
    > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    >
    > 15. Vacuum-deposited silver on polycarbonate with a chromium interlayer

    for improved
    > metal-
    > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.
    >
    > 16. Process for increased metal-substrate bond strength in metalized

    plastics.
    > Holmes-Farley, S.
    > R.; Ger. Offen. 4322516; 7/6/93.
    >
    > 17. Electrorheological fluids and preparation of particles useful in the

    fluids.
    > Troughton,
    > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.

    David; Bares, Joseph
    > E.;
    > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP

    394049;
    > 10/24/1990.
    >
    > JOURNAL PUBLICATIONS
    >
    > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene;

    Guo, Amy;
    > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;

    Mandeville, W. Harry;
    > Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.
    >
    > 2. Amine functionalized polyethers as bile acid sequestrants: synthesis

    and biological
    > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall;

    Mandeville, W.
    > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.

    Journal of
    > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),

    1559-1574.
    >
    > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular

    Imprinting. Huval,
    > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.

    Randall; Mandeville,
    > W.
    > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.;

    Chen, Xi; Dhal,
    > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    >
    > 4. Synthetic polymers for the binding of fat in the intestinal tract.

    Jozefiak, Thomas H.;
    > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval,

    Chad C.;
    > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.

    Abstracts of
    > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August

    26-30, 2001
    > (2001), POLY-047 and Polymer Preprints (American Chemical Society,

    Division of
    > Polymer Chemistry) (2001), 42(2), 98.
    >
    > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel

    pharmaceutical.
    > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward,

    J.; Sacchiero,
    > B.;
    > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen,

    X.; Mazzeo, J.
    > R.. Polym. Preprints (2000), 41(1), 735-736.
    >
    > 6. In vitro comparison of bile acid binding to colesevelam HCl and other

    bile acid
    > sequestrants.
    > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;

    Hook, P.; Holmes-
    > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    >
    > 7. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley,

    S. R; Polym.
    > Mater. Sci. Eng (1999), 80, 246-247.
    >
    > 8. Design and characterization of of Sevelamer Hydrochloride: a novel

    phosphate-binding
    > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.;

    Miller, K. L.;
    > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and

    Appl. Chem.,
    > A36(7&8), p. 1085 (1999).
    >
    > 9. Three generations of bile acid sequestrants. Mandeville, W. H., III;

    Braunlin, W.;
    > Dhal, P.;
    > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;

    Rosenbaum, D.;
    > Sacchiero,
    > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),

    550, 3-15.
    >
    > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate

    binder, on
    > urinary
    > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;

    Mandeville, W. H.,
    > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.

    (1997), 12(5)
    > 961-964.
    >
    > 11. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley,

    S. R.; Yanyo, L.
    > C;
    > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.
    >
    > 12. The mechanism of cure initiation of a surface activated adhesive.

    Holmes-Farley, S.
    > R.;
    > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    >
    > 13. Adhesion promotion and corrosion prevention using thin anisotropic

    coatings. Holmes-
    > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),

    131-151.
    >
    > 14. Wetting of functionalized polyethylene having ionizable organic acids

    and bases at the
    > polymer-water interface: relations between functional group polarity,

    extent of
    > ionization,
    > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;

    Whitesides, G. M.;
    > Langmuir
    > (1988), 4(4), 921-937.
    >
    > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a

    single hydroxy group.
    > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    >
    > 16. Reconstruction of the interface of oxidatively functionalized

    polyethylene (PE-CO2H)
    > and
    > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.;

    McCarthy, T. J.;
    > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987),

    AD-
    > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    >
    > 17. Surface-modified polyethylene film: the relationship between surface

    chemistry and
    > physical
    > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.
    >
    > 18. Reactivity of carboxylic acid and ester groups in the functionalized

    interfacial
    > region of
    > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:

    differentiation of the
    > functional groups into shallow and deep subsets based on a comparison of

    contact angle and
    > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir

    (1987), 3(1), 62-
    > 76.
    >
    > 19. Fluorescence properties of dansyl groups covalently bonded tot he

    surface of
    > oxidatively
    > functionalized low-density polyethylene film. Holmes-Farley, S. R.;

    Whitesides, G. M.;
    > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;

    AD-A162435/2/GAR,
    > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    >
    > 20. Acid-base behavior of carboxylic acid groups covalently attached at

    the surface of
    > polyethylene: The usefulness of contact angle in following the ionization

    of surface
    > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;

    Deutch, J.;
    > Whitesides,
    > G. M.; Langmuir (1985), 1(6), 725-740.
    >
    > 21. The thermal stability of a surface modified solid organic polymer.

    Holmes-Farley, S.
    > R.;
    > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    >
    >
    >
    > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    >
    > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced

    Aquarist. June 2003.
    >
    > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.

    Advanced Aquarist.
    > May
    > 2003.
    >
    > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.

    Reefkeeping May
    > 2003.
    >
    > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping

    April 2003.
    >
    > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced Aquarist;

    March 2003.
    >
    > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.

    Holmes-Farley, R.
    > Advanced Aquarist; February 2003.
    >
    > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January

    2003.
    >
    > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; December

    2002.
    >
    > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R. Advanced

    Aquarist; November
    > 2002.
    >
    > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.

    Advanced Aquarist;
    > November 2002.
    >
    > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced Aquarist,

    September 2002.
    >
    > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August

    2002.
    >
    > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April

    2002.
    >
    > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced

    Aquarist; July 2002
    >
    > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist; June

    2002.
    >
    > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R. Advanced

    Aquarist, May
    > 2002.
    >
    > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.

    Holmes-Farley, R.
    > Advanced Aquarist, April 2002.
    >
    > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    >
    > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    >
    > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January 2002.
    >
    > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium

    Frontiers 2000.
    >
    > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.

    Aquarium Frontiers
    > 2000.
    > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers 2000.
    >
    > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    >
    > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    >
    >
    >
    >
    >
    >
    >
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    >
    >
     
    stoutman, Feb 10, 2004
    #46
  7. Dinky

    stoutman Guest

    I really want to help you understand.

    Here is one of your alk definitions which I do not disagree with. I want to
    explain to you why this tells you something about the buffering capacity.

    Alkalinity = A std acid titration to phenolphthalein endpoint

    During the titration to your end point, if buffers are present, they will
    slow down the fall of the pH. This will require a certain amount of acid to
    reach the endpoint. If no buffers are present, less acid will be needed.
    Therefore, you now can have an idea of the strength of the buffer, which can
    be calculated and expressed.

    The buffers are alkaline (basic) components which make up the "buffering
    capacity". The combined alkaline components (individual buffer components)
    compose your Total Alkalinity.

    As you described here:

    TA = [HCO3-] + 2[CO3--] + [B(OH)4-] + [OH-] + [Si(OH)3O-] + [MgOH+] +
    [HPO4--] + > > 2[PO4---] - [H+]

    Therefore, measuring alkalinity tells you something about your 'buffering
    capacity'.

    alkalinity is an expression of or measurement of 'buffering capacity'.


    DOES THIS HELP?

    RESISTANCE IS FUTILE! <----I thought you might relate to this expression.
    lol




    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102ht0bjplpo059@corp.supernews.com...
    > Now I am getting bored
    >
    > "Don't the components of a buffer account for the buffering capacity?

    Yes."
    >
    > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity and

    Alkalinity are
    > not the same, that has always been the issue. I gave the equation does

    that look like an
    > Alkalinity equation or how Alk is determined. I see you had now comments

    on it what's
    > wrong, why no comments on the equations I gave. Don't understand them or

    what ? Again this
    > is the equation for Buffering Capacity, also called Buffer Index or Buffer

    Intensity. It
    > is defined in most water chemistry and chemical oceanography text books.
    >
    > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa

    [H3O+] / (Ka =
    > H3O+])² )
    >
    > This is not Alkalinity now is it ?
    >
    > "I know how to do a titration, In fact I have done several. How many have
    > you actually done? I don't mean by counting drops, I mean with a buret?"
    >
    > Well good for you, I use a Digital Titrator
    >
    > "Oh, I see,
    > you think acidity is the opposite of alkalinity. In the world of

    CHEMISTRY
    > it's not. Maybe in aquarium newsgroups it is.
    >
    > Hum no, maybe you should go for a look at HACH's or LaMotte website or the

    book I
    > suggested earlier. Please view a copy.
    >
    > Standard Methods for the Examination of Water and Wastewater
    >
    > This book, over 2000 pages, is the guide for water testing. If you are

    reporting water
    > test to the EPA you must use approved std from this text.I t is prepared

    and published by
    > the EPA, American Water Works Association and American Public Health

    Association. You
    > mean you don't have one and the issue is water chemistry
    >
    > You are confusing Acidity and Acidity as you know little about water

    chemistry and
    > procedures and test methods
    >
    > From SMEWW, section 2-30, 2310 ACIDITY
    >
    > "Acidity of water is its quantative capacity to react with a strong base

    to a designated
    > pH"
    >
    > This is how you test for it
    >
    > A std alkali titration to methyl orange or phenolphthalein
    > endpoint.
    >
    > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this

    book, there are
    > over 100 of them, they are wrong.
    >
    > Like Buffering Capacity you have your Acidity's mixed up
    > In water measurement if you have a high Alk you also usually have a high

    Acidity.
    > Normally a high Alk also gives a higher CO2 level. Get a WATER CHEMISTRY

    BOOK there pal.
    >
    >
    > "These are all in equilibrium with each other. An initial high pH (above
    > 6.4) will shift the equilibrium to the right to form HCO3-1. If the pH of
    > the solution is above 10.3 (pKa2) the .........."
    >
    >
    > Christ, there you go again with the FW shit. All your numbers are wrong we

    are dealing
    > with SEAWATER
    >
    > This means that at a pH of 8.3, the majority of the CO2(aq) is in the form
    > of HCO3-1 .
    >
    > I have already pointed that out and gave actual values at know seawater

    levels, go back
    > and re-read it you aren't telling me anything here.Of course most is HCO3

    see...
    >
    >
    > @ 20C and 34.3 ppt salinity
    >
    > CO2 = 0.52 %
    >
    > HCO3 = 86.4 %
    >
    > CO3 = 13.09 %
    >
    >
    > "In your glass experiment you managed to lower the pH enough to purge out

    CO2
    > by boiling"
    >
    > The purpose behind the glass is to show that alk is not affect by CO2 and

    vise-versa and
    > how Co2 affects pH.
    >
    > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH drops

    to say 8.1 it is
    > usually due to excess CO2. If you took a glass of that water and aerated

    it you WILL drive
    > off the CO2 and raise the pH. It has been done a proven a million times.
    >
    > "In order to 'purge' CO2 you would need to lower the
    > pH to shift the equilibrium to below 6.4"
    >
    > The hell you do !!!.Do you know who many times people on this NG to

    include Dr. Craig
    > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a

    sample of aquarium
    > water and aerate it to see if the pH GOES UP AND when they come back with

    the test it is
    > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST excess

    CO2 in the tank
    > water, increase the circulation for better gas exchange at the surface,

    reduce feeding,
    > and try to improve on better skimming, thus reducing the bio-load and pH

    decline due to
    > CO2.
    >
    >
    > "I hope this helps. "
    >
    > Help, how can you when you miss everything. I should be charging you
    >
    > Oh, by the way. Your websites, I have about 50 on these issues, I could

    post them, not to
    > mention I have all those water chemistry books, so there is no need to

    view your sites.
    >
    > Finally are you afraid to come to our Chemistry Forum, afraid to get

    slapped by REAL
    > chemists. I get a charge out of you can't post your ref .I have posted the

    same or similar
    > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts

    there and am the
    > biggest contributor to his forum other than himself or maybe Habib Sheka
    >
    > Hum, here are Randy's ref that he posted. He hosts the website
    >
    > S. RANDY HOLMES-FARLEY
    > Arlington, Massachusetts
    >
    > EDUCATION
    >
    > 1982-1986 Harvard University Cambridge, MA
    > PhD in Chemistry
    > Research Advisor: George Whitesides
    >
    > Investigated the relationship between polymer surface chemistry and

    physical properties
    > through controlled surface modification and testing.
    >
    > 1980-1982 Cornell University Ithaca, NY
    > BA in Chemistry and Biology
    > Graduated Summa Cum Laude
    > Distinction in All Subjects
    > Grade Point: 3.94/4.0
    > Honors research: isolation and characterization of the subunit of CF1

    enzyme
    >
    >
    > 1978-1979 Stanford University Palo Alto, CA
    > Grade Point: 3.55/4.0
    >
    >
    > EXPERIENCE
    >
    > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > (bought out GelTex Pharmaceuticals in 2001)
    > Vice President, Chemical Research 2001-present
    > Senior Director, Chemical Research 1999-2001
    > Director of Chemical Research 1997-1999
    > Manager of Chemical Research 1995-1997
    > Group Leader 1994-1995
    > Senior Research Scientist 1992-1994
    >
    > Helped start GelTex as second employee
    >
    > Managed various research programs with multi-million dollar budgets
    >
    > Supervised research chemists (17+)
    >
    > Co-inventor of several polymeric pharmaceuticals and pharmaceutical

    candidates including
    > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride (FDA

    approved)
    >
    > Company Safety Officer for 3 years
    >
    > Chemical Hygiene Officer 2000-present
    >
    >
    >
    >
    > 1990-1992 GTE Corporation Waltham, MA
    > Senior Member of Technical Staff
    > Applied research involving polymer interfaces
    > Metallization of plastics
    > Polymer/polymer adhesion
    > Optical coatings
    >
    >
    >
    > 1986-1990 Lord Corporation Cary, NC
    > Senior Research Scientist 1988-1990
    > Research Scientist 1986-1988
    > Basic and applied research on surface chemical bonding
    > Developed new adhesive compositions
    > Developed new sol-gel coatings for corrosion resistance
    >
    >
    > HONORS AND AWARDS
    >
    > Industrial Innovations Award by Northeast Region of American Chemical

    Society (6/2001)
    >
    > National Kidney Foundation of Northern California Honoree (5/2001)
    >
    > American Chemical Society/Polymer Chemistry Division Industrial Sponsors
    > Award (8/2000)
    >
    > R&D 100 Award from R&D magazine (1999)
    >
    > Sherwin Williams Award in applied polymer science (9/85)
    >
    > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    >
    > Award for highest GPA in Chemistry Department (6/82)
    >
    > Summa Cum Laude Honors in Chemistry (6/82)
    >
    > Phi Lamda Epsilon (6/82)
    >
    > Phi Beta Kappa (2/82)
    >
    > Cornell University Dean's List (1981, 1982)
    >
    > Harvard Book Club Award for highest GPA senior year (1978)
    >
    > First Place in western NY ACS high school chemistry exam (1977)
    >
    > 1978-1979
    >
    >
    > __________________
    > Randy Holmes-Farley
    > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    >
    > Hobby Experience: 8 years with reefs
    > Current Tanks: 90 gal mixed reef
    > Interests: Reefkeeping, science, photography
    >
    >
    > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    >
    > Open this post in a new window | Report this post to a moderator | IP:

    Logged
    >
    >
    >
    > 06/27/2003 02:44 PM
    >
    > Randy Holmes-Farley
    > Chemistry Moderator
    >
    > Registered: Apr 2001
    > Location: Arlington, Massachusetts
    > Occupation: Chemist (Drug Discovery at Genzyme)
    > Posts: 15282
    >
    >
    >
    > Publications
    >
    >
    > ISSUED UNITED STATES PATENTS
    >
    >
    > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;

    Mandeville, III; W. Harry.
    > US 6,566,407; 5/20/2003
    >
    > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall;

    Huval, Chad
    > Cori.
    > U.S. 6,517,825; 2/11/2003.
    >
    > 3. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley,
    > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.

    6,509,013; 1/21/2003.
    >
    > 4. Combination therapy for treating hypercholesterolemia using a bile acid

    sequestrant
    > polymer
    > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen

    Randall;
    > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    >
    > 5. Method for treating hypercholesterolemia with polyallylamine polymers.

    Holmes-Farley,
    > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg,

    Dennis I. , US
    > 6,423,754; 7/23/2002.
    >
    > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;

    Neenan, Thomas X..;
    > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    >
    > 7. Combination therapy for treating hypercholesterolemia and

    atherosclerosis. Huval, Chad
    > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K.

    U.S. 6,365,186;
    > 4/2/2002.
    >
    > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville,

    W. H., III;
    > Huval; C.
    > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;

    10/9/2001.
    >
    > 9. Polymers containing guanidinium groups as bile acid sequestrants. Dhal;

    P. K.; Holmes-
    > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    >
    > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,281,252;
    > 8/28/2001.
    >
    > 11. Combination therapy for treating hypercholestrolemia. Huval; C. C.;

    Holmes-Farley; S.
    > R. ;
    > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    >
    > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;

    Holmes-Farley, S.
    > R.; US
    > 6,264,937; 7/24/2001.
    >
    > 13. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,248,318;
    > 6/19/2001.
    >
    > 14. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    >
    > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.;

    Dhal, P. K.;
    > Petersen,
    > J. S.; US 6,203,785; 3/20/2001.
    >
    > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval,

    C. C.; US
    > 6,190,649;
    > 2/20/2001.
    >
    > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,177,478;
    > 1/23/2001.
    >
    > 18. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley,

    S. R.;
    > Mandeville, W.
    > H., III.; US 6,129,910; 10/10/2000.
    >
    > 19. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,083,497;
    > 7/4/2000.
    >
    > 20. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley, S.
    > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.
    >
    > 21. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.
    >
    > 22. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    >
    > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;

    Neenan; T. X.; Holmes-
    > Farley; S. R. US 6,034,129; 3/7/2000.
    >
    > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 5,985,938;
    > 11/16/99.
    >
    > 25. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    >
    > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H.,

    III.;
    > Holmes-Farley;
    > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    >
    > 27. Hydrophilic nonamine-containing and amine-containing copolymers and

    their use as bile
    > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184;

    7/27/99.
    >
    > 28. Interpenetrating polymer networks for sequestration of bile acids.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;

    7/20/99.
    >
    > 29. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    >
    > 30. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    >
    > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    >
    > 32. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    >
    > 33. Preparation of polymeric sequestrants for bile acid salts. Mandeville,

    W. H., III.;
    > Holmes-
    > Farley, S. R.; US 5,703,188; 12/30/97.
    >
    > 34. Oral administration of iron-binding crosslinked amine polymers.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    >
    > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S.

    R.; US 5,693,675;
    > 12/2/97.
    >
    > 36. Method for removing bile salts from a patient with alkylated

    crosslinked amine
    > polymers,
    > and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley,

    S. R.; US
    > 5,679,717; 10/21/97.
    >
    > 37. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,667,775; 9/16/97.
    >
    > 38. Ion-exchange process using highly crosslinked polymers for removing

    bile salts from a
    > patient, preparation of the polymers, and compositions containing them.

    Mandeville, W. H.,
    > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    >
    > 39. Hydrophobic amine polymer sequestrant and method of cholesterol

    depletion. Mandeville,
    > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.
    >
    > 40. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    >
    > 41. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,496,545; 3/5/96.
    >
    > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,

    III.; Holmes-Farley,
    > S. R.;
    > US 5,487,888; 1/30/96.
    >
    > 43. Ultra-thin, uniform sol-gel coating of a substrate having active

    hydrogens on the
    > surface.
    > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    >
    > 44. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley,

    S. R.; Yanyo, L.
    > C.;
    > US 5,182,143; 1/26/93.
    >
    > 45. Method for metal bonding using ultrathin primer coating.

    Holmes-Farley, S. R.; Yanyo,
    > L.
    > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    >
    > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US

    5,096,962;
    > 3/17/92.
    >
    > 47. Modified halogenatedpolyolefin adhesives for polyolefin

    elastomer-metal bonding.
    > Holmes-
    > Farley, S. R.; US 5,102,956; 4/7/92.
    >
    >
    >
    > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    >
    >
    > 1. Aryl boronate functionalized polymers for treating obesity and

    inhibiting fat uptake.
    > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal, Pradeep

    K.; Huval, Chad
    > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92 pp. WO

    0302571.
    >
    > 2. Preparation of aryl boronic acids for treating obesity. Holmes-Farley,

    Stephen Randall;
    > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep K.

    (Geltex
    > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    >
    > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,

    Stephen Randall.
    > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO

    0302130.
    >
    > 4. Method for reducing copper levels and treating copper toxicosis.

    Holmes-Farley, Stephen
    > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45

    pp. WO
    > 0285383.
    >
    > 5. Method for treating gout and binding uric acid. Holmes-Farley, Stephen

    Randall; Burke,
    > Steven K. WO 0285381 10/31/2002.
    >
    > 6. Method for treating gout and reducing serum uric acid. Holmes-Farley,

    Stephen Randall;
    > Burke, Steven K WO 0285380 10/31/2002.
    >
    > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;

    Holmes-Farley, S. R.;
    > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    >
    > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 1999-US5662; 9/23/1999.
    >
    > 9. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley,

    S. R.; Petersen,
    > J. S.;
    > WO 9933452; 7/8/1999.
    >
    > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 9922743; 5/14/1999.
    >
    > 11. Polyallylamine polymers for removing bile salts and treating

    hypercholesterolemia, and
    > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke,

    S. K.; Goldberg,
    > D. I.; WO 9857652; 12/23/98.
    >
    > 12. Phosphate-bidning polymers combined with a calcium supplement for oral

    administration.
    > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S.

    R.; WO 9842355;
    > 10/1/98.
    >
    > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol

    depletion. Mandeville,
    > W.
    > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    >
    > 14. Process for adjusting ion concentration in a patient and compositions

    therefor.
    > Mandeville,
    > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    >
    > 15. Vacuum-deposited silver on polycarbonate with a chromium interlayer

    for improved
    > metal-
    > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.
    >
    > 16. Process for increased metal-substrate bond strength in metalized

    plastics.
    > Holmes-Farley, S.
    > R.; Ger. Offen. 4322516; 7/6/93.
    >
    > 17. Electrorheological fluids and preparation of particles useful in the

    fluids.
    > Troughton,
    > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.

    David; Bares, Joseph
    > E.;
    > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP

    394049;
    > 10/24/1990.
    >
    > JOURNAL PUBLICATIONS
    >
    > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene;

    Guo, Amy;
    > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;

    Mandeville, W. Harry;
    > Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.
    >
    > 2. Amine functionalized polyethers as bile acid sequestrants: synthesis

    and biological
    > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall;

    Mandeville, W.
    > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.

    Journal of
    > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),

    1559-1574.
    >
    > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular

    Imprinting. Huval,
    > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.

    Randall; Mandeville,
    > W.
    > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.;

    Chen, Xi; Dhal,
    > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    >
    > 4. Synthetic polymers for the binding of fat in the intestinal tract.

    Jozefiak, Thomas H.;
    > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval,

    Chad C.;
    > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.

    Abstracts of
    > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August

    26-30, 2001
    > (2001), POLY-047 and Polymer Preprints (American Chemical Society,

    Division of
    > Polymer Chemistry) (2001), 42(2), 98.
    >
    > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel

    pharmaceutical.
    > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward,

    J.; Sacchiero,
    > B.;
    > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen,

    X.; Mazzeo, J.
    > R.. Polym. Preprints (2000), 41(1), 735-736.
    >
    > 6. In vitro comparison of bile acid binding to colesevelam HCl and other

    bile acid
    > sequestrants.
    > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;

    Hook, P.; Holmes-
    > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    >
    > 7. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley,

    S. R; Polym.
    > Mater. Sci. Eng (1999), 80, 246-247.
    >
    > 8. Design and characterization of of Sevelamer Hydrochloride: a novel

    phosphate-binding
    > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.;

    Miller, K. L.;
    > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and

    Appl. Chem.,
    > A36(7&8), p. 1085 (1999).
    >
    > 9. Three generations of bile acid sequestrants. Mandeville, W. H., III;

    Braunlin, W.;
    > Dhal, P.;
    > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;

    Rosenbaum, D.;
    > Sacchiero,
    > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),

    550, 3-15.
    >
    > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate

    binder, on
    > urinary
    > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;

    Mandeville, W. H.,
    > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.

    (1997), 12(5)
    > 961-964.
    >
    > 11. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley,

    S. R.; Yanyo, L.
    > C;
    > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.
    >
    > 12. The mechanism of cure initiation of a surface activated adhesive.

    Holmes-Farley, S.
    > R.;
    > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    >
    > 13. Adhesion promotion and corrosion prevention using thin anisotropic

    coatings. Holmes-
    > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),

    131-151.
    >
    > 14. Wetting of functionalized polyethylene having ionizable organic acids

    and bases at the
    > polymer-water interface: relations between functional group polarity,

    extent of
    > ionization,
    > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;

    Whitesides, G. M.;
    > Langmuir
    > (1988), 4(4), 921-937.
    >
    > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a

    single hydroxy group.
    > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    >
    > 16. Reconstruction of the interface of oxidatively functionalized

    polyethylene (PE-CO2H)
    > and
    > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.;

    McCarthy, T. J.;
    > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987),

    AD-
    > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    >
    > 17. Surface-modified polyethylene film: the relationship between surface

    chemistry and
    > physical
    > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.
    >
    > 18. Reactivity of carboxylic acid and ester groups in the functionalized

    interfacial
    > region of
    > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:

    differentiation of the
    > functional groups into shallow and deep subsets based on a comparison of

    contact angle and
    > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir

    (1987), 3(1), 62-
    > 76.
    >
    > 19. Fluorescence properties of dansyl groups covalently bonded tot he

    surface of
    > oxidatively
    > functionalized low-density polyethylene film. Holmes-Farley, S. R.;

    Whitesides, G. M.;
    > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;

    AD-A162435/2/GAR,
    > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    >
    > 20. Acid-base behavior of carboxylic acid groups covalently attached at

    the surface of
    > polyethylene: The usefulness of contact angle in following the ionization

    of surface
    > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;

    Deutch, J.;
    > Whitesides,
    > G. M.; Langmuir (1985), 1(6), 725-740.
    >
    > 21. The thermal stability of a surface modified solid organic polymer.

    Holmes-Farley, S.
    > R.;
    > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    >
    >
    >
    > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    >
    > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced

    Aquarist. June 2003.
    >
    > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.

    Advanced Aquarist.
    > May
    > 2003.
    >
    > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.

    Reefkeeping May
    > 2003.
    >
    > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping

    April 2003.
    >
    > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced Aquarist;

    March 2003.
    >
    > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.

    Holmes-Farley, R.
    > Advanced Aquarist; February 2003.
    >
    > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January

    2003.
    >
    > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; December

    2002.
    >
    > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R. Advanced

    Aquarist; November
    > 2002.
    >
    > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.

    Advanced Aquarist;
    > November 2002.
    >
    > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced Aquarist,

    September 2002.
    >
    > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August

    2002.
    >
    > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April

    2002.
    >
    > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced

    Aquarist; July 2002
    >
    > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist; June

    2002.
    >
    > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R. Advanced

    Aquarist, May
    > 2002.
    >
    > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.

    Holmes-Farley, R.
    > Advanced Aquarist, April 2002.
    >
    > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    >
    > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    >
    > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January 2002.
    >
    > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium

    Frontiers 2000.
    >
    > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.

    Aquarium Frontiers
    > 2000.
    > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers 2000.
    >
    > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    >
    > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    >
    >
    >
    >
    >
    >
    >
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    >
    >
     
    stoutman, Feb 10, 2004
    #47
  8. Dinky

    stoutman Guest

    Boomer, sorry for the name calling in the previous post.


    Let me respond to your equation question that you are stuck on.

    B (Buffering Index) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa [H3O+]
    / (Ka + H3O+])² )


    C = total concentration of the acid + conjugate base = [HA] + [A-]
    Unknown
    Ka = acid dissociation constant. Found in a table
    [H3O] = Determined from pH. where pH = -log [H+]

    Only unknown in the equation is C which is [HA] + [A-].

    In this case the conjugate base is CO3- and the acid is HCO3-2 and Ka is
    Ka2 for carbonic acid.

    One way to solve the equation is to determine the combined concentrations of
    :[CO3-] and [HCO3-2] in solution.

    Do you recognize [HCO3-1] and [CO3-2] from another equation ? Yes, your
    alkalinity equation.

    So when we measure ALKALINITY we are indirectly measuring BUFFERING
    CAPACITY.

    Because aquarium and sea water have other buffers in solution, you need to
    determine the BUFFERING INDEX for each buffer in solution.

    Does this help? Or are we NEVER going to agree on anything?




    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102ht0bjplpo059@corp.supernews.com...
    > Now I am getting bored
    >
    > "Don't the components of a buffer account for the buffering capacity?

    Yes."
    >
    > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity and

    Alkalinity are
    > not the same, that has always been the issue. I gave the equation does

    that look like an
    > Alkalinity equation or how Alk is determined. I see you had now comments

    on it what's
    > wrong, why no comments on the equations I gave. Don't understand them or

    what ? Again this
    > is the equation for Buffering Capacity, also called Buffer Index or Buffer

    Intensity. It
    > is defined in most water chemistry and chemical oceanography text books.
    >
    > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa

    [H3O+] / (Ka =
    > H3O+])² )
    >
    > This is not Alkalinity now is it ?
    >
    > "I know how to do a titration, In fact I have done several. How many have
    > you actually done? I don't mean by counting drops, I mean with a buret?"
    >
    > Well good for you, I use a Digital Titrator
    >
    > "Oh, I see,
    > you think acidity is the opposite of alkalinity. In the world of

    CHEMISTRY
    > it's not. Maybe in aquarium newsgroups it is.
    >
    > Hum no, maybe you should go for a look at HACH's or LaMotte website or the

    book I
    > suggested earlier. Please view a copy.
    >
    > Standard Methods for the Examination of Water and Wastewater
    >
    > This book, over 2000 pages, is the guide for water testing. If you are

    reporting water
    > test to the EPA you must use approved std from this text.I t is prepared

    and published by
    > the EPA, American Water Works Association and American Public Health

    Association. You
    > mean you don't have one and the issue is water chemistry
    >
    > You are confusing Acidity and Acidity as you know little about water

    chemistry and
    > procedures and test methods
    >
    > From SMEWW, section 2-30, 2310 ACIDITY
    >
    > "Acidity of water is its quantative capacity to react with a strong base

    to a designated
    > pH"
    >
    > This is how you test for it
    >
    > A std alkali titration to methyl orange or phenolphthalein
    > endpoint.
    >
    > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this

    book, there are
    > over 100 of them, they are wrong.
    >
    > Like Buffering Capacity you have your Acidity's mixed up
    > In water measurement if you have a high Alk you also usually have a high

    Acidity.
    > Normally a high Alk also gives a higher CO2 level. Get a WATER CHEMISTRY

    BOOK there pal.
    >
    >
    > "These are all in equilibrium with each other. An initial high pH (above
    > 6.4) will shift the equilibrium to the right to form HCO3-1. If the pH of
    > the solution is above 10.3 (pKa2) the .........."
    >
    >
    > Christ, there you go again with the FW shit. All your numbers are wrong we

    are dealing
    > with SEAWATER
    >
    > This means that at a pH of 8.3, the majority of the CO2(aq) is in the form
    > of HCO3-1 .
    >
    > I have already pointed that out and gave actual values at know seawater

    levels, go back
    > and re-read it you aren't telling me anything here.Of course most is HCO3

    see...
    >
    >
    > @ 20C and 34.3 ppt salinity
    >
    > CO2 = 0.52 %
    >
    > HCO3 = 86.4 %
    >
    > CO3 = 13.09 %
    >
    >
    > "In your glass experiment you managed to lower the pH enough to purge out

    CO2
    > by boiling"
    >
    > The purpose behind the glass is to show that alk is not affect by CO2 and

    vise-versa and
    > how Co2 affects pH.
    >
    > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH drops

    to say 8.1 it is
    > usually due to excess CO2. If you took a glass of that water and aerated

    it you WILL drive
    > off the CO2 and raise the pH. It has been done a proven a million times.
    >
    > "In order to 'purge' CO2 you would need to lower the
    > pH to shift the equilibrium to below 6.4"
    >
    > The hell you do !!!.Do you know who many times people on this NG to

    include Dr. Craig
    > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a

    sample of aquarium
    > water and aerate it to see if the pH GOES UP AND when they come back with

    the test it is
    > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST excess

    CO2 in the tank
    > water, increase the circulation for better gas exchange at the surface,

    reduce feeding,
    > and try to improve on better skimming, thus reducing the bio-load and pH

    decline due to
    > CO2.
    >
    >
    > "I hope this helps. "
    >
    > Help, how can you when you miss everything. I should be charging you
    >
    > Oh, by the way. Your websites, I have about 50 on these issues, I could

    post them, not to
    > mention I have all those water chemistry books, so there is no need to

    view your sites.
    >
    > Finally are you afraid to come to our Chemistry Forum, afraid to get

    slapped by REAL
    > chemists. I get a charge out of you can't post your ref .I have posted the

    same or similar
    > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts

    there and am the
    > biggest contributor to his forum other than himself or maybe Habib Sheka
    >
    > Hum, here are Randy's ref that he posted. He hosts the website
    >
    > S. RANDY HOLMES-FARLEY
    > Arlington, Massachusetts
    >
    > EDUCATION
    >
    > 1982-1986 Harvard University Cambridge, MA
    > PhD in Chemistry
    > Research Advisor: George Whitesides
    >
    > Investigated the relationship between polymer surface chemistry and

    physical properties
    > through controlled surface modification and testing.
    >
    > 1980-1982 Cornell University Ithaca, NY
    > BA in Chemistry and Biology
    > Graduated Summa Cum Laude
    > Distinction in All Subjects
    > Grade Point: 3.94/4.0
    > Honors research: isolation and characterization of the subunit of CF1

    enzyme
    >
    >
    > 1978-1979 Stanford University Palo Alto, CA
    > Grade Point: 3.55/4.0
    >
    >
    > EXPERIENCE
    >
    > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > (bought out GelTex Pharmaceuticals in 2001)
    > Vice President, Chemical Research 2001-present
    > Senior Director, Chemical Research 1999-2001
    > Director of Chemical Research 1997-1999
    > Manager of Chemical Research 1995-1997
    > Group Leader 1994-1995
    > Senior Research Scientist 1992-1994
    >
    > Helped start GelTex as second employee
    >
    > Managed various research programs with multi-million dollar budgets
    >
    > Supervised research chemists (17+)
    >
    > Co-inventor of several polymeric pharmaceuticals and pharmaceutical

    candidates including
    > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride (FDA

    approved)
    >
    > Company Safety Officer for 3 years
    >
    > Chemical Hygiene Officer 2000-present
    >
    >
    >
    >
    > 1990-1992 GTE Corporation Waltham, MA
    > Senior Member of Technical Staff
    > Applied research involving polymer interfaces
    > Metallization of plastics
    > Polymer/polymer adhesion
    > Optical coatings
    >
    >
    >
    > 1986-1990 Lord Corporation Cary, NC
    > Senior Research Scientist 1988-1990
    > Research Scientist 1986-1988
    > Basic and applied research on surface chemical bonding
    > Developed new adhesive compositions
    > Developed new sol-gel coatings for corrosion resistance
    >
    >
    > HONORS AND AWARDS
    >
    > Industrial Innovations Award by Northeast Region of American Chemical

    Society (6/2001)
    >
    > National Kidney Foundation of Northern California Honoree (5/2001)
    >
    > American Chemical Society/Polymer Chemistry Division Industrial Sponsors
    > Award (8/2000)
    >
    > R&D 100 Award from R&D magazine (1999)
    >
    > Sherwin Williams Award in applied polymer science (9/85)
    >
    > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    >
    > Award for highest GPA in Chemistry Department (6/82)
    >
    > Summa Cum Laude Honors in Chemistry (6/82)
    >
    > Phi Lamda Epsilon (6/82)
    >
    > Phi Beta Kappa (2/82)
    >
    > Cornell University Dean's List (1981, 1982)
    >
    > Harvard Book Club Award for highest GPA senior year (1978)
    >
    > First Place in western NY ACS high school chemistry exam (1977)
    >
    > 1978-1979
    >
    >
    > __________________
    > Randy Holmes-Farley
    > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    >
    > Hobby Experience: 8 years with reefs
    > Current Tanks: 90 gal mixed reef
    > Interests: Reefkeeping, science, photography
    >
    >
    > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    >
    > Open this post in a new window | Report this post to a moderator | IP:

    Logged
    >
    >
    >
    > 06/27/2003 02:44 PM
    >
    > Randy Holmes-Farley
    > Chemistry Moderator
    >
    > Registered: Apr 2001
    > Location: Arlington, Massachusetts
    > Occupation: Chemist (Drug Discovery at Genzyme)
    > Posts: 15282
    >
    >
    >
    > Publications
    >
    >
    > ISSUED UNITED STATES PATENTS
    >
    >
    > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;

    Mandeville, III; W. Harry.
    > US 6,566,407; 5/20/2003
    >
    > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall;

    Huval, Chad
    > Cori.
    > U.S. 6,517,825; 2/11/2003.
    >
    > 3. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley,
    > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.

    6,509,013; 1/21/2003.
    >
    > 4. Combination therapy for treating hypercholesterolemia using a bile acid

    sequestrant
    > polymer
    > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen

    Randall;
    > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    >
    > 5. Method for treating hypercholesterolemia with polyallylamine polymers.

    Holmes-Farley,
    > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg,

    Dennis I. , US
    > 6,423,754; 7/23/2002.
    >
    > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;

    Neenan, Thomas X..;
    > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    >
    > 7. Combination therapy for treating hypercholesterolemia and

    atherosclerosis. Huval, Chad
    > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K.

    U.S. 6,365,186;
    > 4/2/2002.
    >
    > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville,

    W. H., III;
    > Huval; C.
    > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;

    10/9/2001.
    >
    > 9. Polymers containing guanidinium groups as bile acid sequestrants. Dhal;

    P. K.; Holmes-
    > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    >
    > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,281,252;
    > 8/28/2001.
    >
    > 11. Combination therapy for treating hypercholestrolemia. Huval; C. C.;

    Holmes-Farley; S.
    > R. ;
    > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    >
    > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;

    Holmes-Farley, S.
    > R.; US
    > 6,264,937; 7/24/2001.
    >
    > 13. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,248,318;
    > 6/19/2001.
    >
    > 14. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    >
    > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.;

    Dhal, P. K.;
    > Petersen,
    > J. S.; US 6,203,785; 3/20/2001.
    >
    > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval,

    C. C.; US
    > 6,190,649;
    > 2/20/2001.
    >
    > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 6,177,478;
    > 1/23/2001.
    >
    > 18. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley,

    S. R.;
    > Mandeville, W.
    > H., III.; US 6,129,910; 10/10/2000.
    >
    > 19. Method for treating hypercholesterolemia with unsubstituted

    polydiallylamine polymers.
    > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US

    6,083,497;
    > 7/4/2000.
    >
    > 20. Method of making phosphate-binding polymers for oral administration.

    Holmes-Farley, S.
    > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.
    >
    > 21. Process for removing bile salts from a patient and alkylated

    compositions therefore.
    > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.
    >
    > 22. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    >
    > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;

    Neenan; T. X.; Holmes-
    > Farley; S. R. US 6,034,129; 3/7/2000.
    >
    > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,

    III.; US
    > 5,985,938;
    > 11/16/99.
    >
    > 25. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    >
    > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H.,

    III.;
    > Holmes-Farley;
    > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    >
    > 27. Hydrophilic nonamine-containing and amine-containing copolymers and

    their use as bile
    > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184;

    7/27/99.
    >
    > 28. Interpenetrating polymer networks for sequestration of bile acids.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;

    7/20/99.
    >
    > 29. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    >
    > 30. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    >
    > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    >
    > 32. Process for removing bile salts from a patient and compositions

    therefor. Mandeville,
    > W. H.,
    > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    >
    > 33. Preparation of polymeric sequestrants for bile acid salts. Mandeville,

    W. H., III.;
    > Holmes-
    > Farley, S. R.; US 5,703,188; 12/30/97.
    >
    > 34. Oral administration of iron-binding crosslinked amine polymers.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    >
    > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S.

    R.; US 5,693,675;
    > 12/2/97.
    >
    > 36. Method for removing bile salts from a patient with alkylated

    crosslinked amine
    > polymers,
    > and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley,

    S. R.; US
    > 5,679,717; 10/21/97.
    >
    > 37. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,667,775; 9/16/97.
    >
    > 38. Ion-exchange process using highly crosslinked polymers for removing

    bile salts from a
    > patient, preparation of the polymers, and compositions containing them.

    Mandeville, W. H.,
    > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    >
    > 39. Hydrophobic amine polymer sequestrant and method of cholesterol

    depletion. Mandeville,
    > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.
    >
    > 40. Amine polymer sequestrant and method of cholesterol depletion.

    Mandeville, W. H.,
    > III.;
    > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    >
    > 41. Phosphate-binding polymers for oral administration. Holmes-Farley, S.

    R.; Mandeville,
    > W.
    > H., III.; US 5,496,545; 3/5/96.
    >
    > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,

    III.; Holmes-Farley,
    > S. R.;
    > US 5,487,888; 1/30/96.
    >
    > 43. Ultra-thin, uniform sol-gel coating of a substrate having active

    hydrogens on the
    > surface.
    > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    >
    > 44. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley,

    S. R.; Yanyo, L.
    > C.;
    > US 5,182,143; 1/26/93.
    >
    > 45. Method for metal bonding using ultrathin primer coating.

    Holmes-Farley, S. R.; Yanyo,
    > L.
    > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    >
    > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US

    5,096,962;
    > 3/17/92.
    >
    > 47. Modified halogenatedpolyolefin adhesives for polyolefin

    elastomer-metal bonding.
    > Holmes-
    > Farley, S. R.; US 5,102,956; 4/7/92.
    >
    >
    >
    > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    >
    >
    > 1. Aryl boronate functionalized polymers for treating obesity and

    inhibiting fat uptake.
    > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal, Pradeep

    K.; Huval, Chad
    > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92 pp. WO

    0302571.
    >
    > 2. Preparation of aryl boronic acids for treating obesity. Holmes-Farley,

    Stephen Randall;
    > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep K.

    (Geltex
    > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    >
    > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,

    Stephen Randall.
    > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO

    0302130.
    >
    > 4. Method for reducing copper levels and treating copper toxicosis.

    Holmes-Farley, Stephen
    > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45

    pp. WO
    > 0285383.
    >
    > 5. Method for treating gout and binding uric acid. Holmes-Farley, Stephen

    Randall; Burke,
    > Steven K. WO 0285381 10/31/2002.
    >
    > 6. Method for treating gout and reducing serum uric acid. Holmes-Farley,

    Stephen Randall;
    > Burke, Steven K WO 0285380 10/31/2002.
    >
    > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;

    Holmes-Farley, S. R.;
    > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    >
    > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 1999-US5662; 9/23/1999.
    >
    > 9. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley,

    S. R.; Petersen,
    > J. S.;
    > WO 9933452; 7/8/1999.
    >
    > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and

    Holmes-Farley, S.
    > R.;
    > WO 9922743; 5/14/1999.
    >
    > 11. Polyallylamine polymers for removing bile salts and treating

    hypercholesterolemia, and
    > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke,

    S. K.; Goldberg,
    > D. I.; WO 9857652; 12/23/98.
    >
    > 12. Phosphate-bidning polymers combined with a calcium supplement for oral

    administration.
    > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S.

    R.; WO 9842355;
    > 10/1/98.
    >
    > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol

    depletion. Mandeville,
    > W.
    > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    >
    > 14. Process for adjusting ion concentration in a patient and compositions

    therefor.
    > Mandeville,
    > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    >
    > 15. Vacuum-deposited silver on polycarbonate with a chromium interlayer

    for improved
    > metal-
    > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.
    >
    > 16. Process for increased metal-substrate bond strength in metalized

    plastics.
    > Holmes-Farley, S.
    > R.; Ger. Offen. 4322516; 7/6/93.
    >
    > 17. Electrorheological fluids and preparation of particles useful in the

    fluids.
    > Troughton,
    > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.

    David; Bares, Joseph
    > E.;
    > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP

    394049;
    > 10/24/1990.
    >
    > JOURNAL PUBLICATIONS
    >
    > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene;

    Guo, Amy;
    > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;

    Mandeville, W. Harry;
    > Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.
    >
    > 2. Amine functionalized polyethers as bile acid sequestrants: synthesis

    and biological
    > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall;

    Mandeville, W.
    > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.

    Journal of
    > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),

    1559-1574.
    >
    > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular

    Imprinting. Huval,
    > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.

    Randall; Mandeville,
    > W.
    > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.;

    Chen, Xi; Dhal,
    > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    >
    > 4. Synthetic polymers for the binding of fat in the intestinal tract.

    Jozefiak, Thomas H.;
    > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval,

    Chad C.;
    > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.

    Abstracts of
    > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August

    26-30, 2001
    > (2001), POLY-047 and Polymer Preprints (American Chemical Society,

    Division of
    > Polymer Chemistry) (2001), 42(2), 98.
    >
    > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel

    pharmaceutical.
    > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward,

    J.; Sacchiero,
    > B.;
    > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen,

    X.; Mazzeo, J.
    > R.. Polym. Preprints (2000), 41(1), 735-736.
    >
    > 6. In vitro comparison of bile acid binding to colesevelam HCl and other

    bile acid
    > sequestrants.
    > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;

    Hook, P.; Holmes-
    > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    >
    > 7. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley,

    S. R; Polym.
    > Mater. Sci. Eng (1999), 80, 246-247.
    >
    > 8. Design and characterization of of Sevelamer Hydrochloride: a novel

    phosphate-binding
    > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.;

    Miller, K. L.;
    > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and

    Appl. Chem.,
    > A36(7&8), p. 1085 (1999).
    >
    > 9. Three generations of bile acid sequestrants. Mandeville, W. H., III;

    Braunlin, W.;
    > Dhal, P.;
    > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;

    Rosenbaum, D.;
    > Sacchiero,
    > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),

    550, 3-15.
    >
    > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate

    binder, on
    > urinary
    > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;

    Mandeville, W. H.,
    > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.

    (1997), 12(5)
    > 961-964.
    >
    > 11. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley,

    S. R.; Yanyo, L.
    > C;
    > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.
    >
    > 12. The mechanism of cure initiation of a surface activated adhesive.

    Holmes-Farley, S.
    > R.;
    > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    >
    > 13. Adhesion promotion and corrosion prevention using thin anisotropic

    coatings. Holmes-
    > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),

    131-151.
    >
    > 14. Wetting of functionalized polyethylene having ionizable organic acids

    and bases at the
    > polymer-water interface: relations between functional group polarity,

    extent of
    > ionization,
    > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;

    Whitesides, G. M.;
    > Langmuir
    > (1988), 4(4), 921-937.
    >
    > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a

    single hydroxy group.
    > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    >
    > 16. Reconstruction of the interface of oxidatively functionalized

    polyethylene (PE-CO2H)
    > and
    > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.;

    McCarthy, T. J.;
    > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987),

    AD-
    > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    >
    > 17. Surface-modified polyethylene film: the relationship between surface

    chemistry and
    > physical
    > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.
    >
    > 18. Reactivity of carboxylic acid and ester groups in the functionalized

    interfacial
    > region of
    > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:

    differentiation of the
    > functional groups into shallow and deep subsets based on a comparison of

    contact angle and
    > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir

    (1987), 3(1), 62-
    > 76.
    >
    > 19. Fluorescence properties of dansyl groups covalently bonded tot he

    surface of
    > oxidatively
    > functionalized low-density polyethylene film. Holmes-Farley, S. R.;

    Whitesides, G. M.;
    > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;

    AD-A162435/2/GAR,
    > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    >
    > 20. Acid-base behavior of carboxylic acid groups covalently attached at

    the surface of
    > polyethylene: The usefulness of contact angle in following the ionization

    of surface
    > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;

    Deutch, J.;
    > Whitesides,
    > G. M.; Langmuir (1985), 1(6), 725-740.
    >
    > 21. The thermal stability of a surface modified solid organic polymer.

    Holmes-Farley, S.
    > R.;
    > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    >
    >
    >
    > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    >
    > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced

    Aquarist. June 2003.
    >
    > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.

    Advanced Aquarist.
    > May
    > 2003.
    >
    > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.

    Reefkeeping May
    > 2003.
    >
    > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping

    April 2003.
    >
    > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.

    Holmes-Farley, R.
    > Advanced Aquarist; April 2003.
    >
    > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced Aquarist;

    March 2003.
    >
    > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.

    Holmes-Farley, R.
    > Advanced Aquarist; February 2003.
    >
    > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January

    2003.
    >
    > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; December

    2002.
    >
    > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R. Advanced

    Aquarist; November
    > 2002.
    >
    > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.

    Advanced Aquarist;
    > November 2002.
    >
    > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced Aquarist,

    September 2002.
    >
    > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August

    2002.
    >
    > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April

    2002.
    >
    > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced

    Aquarist; July 2002
    >
    > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist; June

    2002.
    >
    > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R. Advanced

    Aquarist, May
    > 2002.
    >
    > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.

    Holmes-Farley, R.
    > Advanced Aquarist, April 2002.
    >
    > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    >
    > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    >
    > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January 2002.
    >
    > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium

    Frontiers 2000.
    >
    > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.

    Aquarium Frontiers
    > 2000.
    > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium Frontiers

    2000.
    >
    > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers 2000.
    >
    > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    >
    > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    >
    >
    >
    >
    >
    >
    >
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    >
    >
     
    stoutman, Feb 10, 2004
    #48
  9. Dinky

    Boomer Guest

    Allot of things to answer now lets see what you accept or don't expect, based on std ref,
    all by chemists, not by me. I have lots of problems with these last few posts, so I guess
    it is time I put you somewhat in place in comments you made, WITHOUT you even checking the
    ref. Bad move on your part, so lets see what you have to say when I'm done, no name
    calling by me, just trying to get you to see a few things.......and help YOU on
    something's you seem not to know about.


    "I never said alkalinity and buffering capacity are the same thing. When did
    I say that? Now you are twisting my words."


    ***alkalinity is a measurement of 'buffering capacity'***

    Which comes across to me that they are the same thing. Alkalinity is not a measurement of
    BC(see below)

    I don't need the links I have many and some are the same as yours. I think we are on a
    word game, lets call it that, maybe a misunderstanding. As I had posted earlier,
    (Millero/per com), Bc is the ability to withstand both upward and downward trends in pH
    and Alk is the ability to withstand downward trends in pH


    From

    Benjamin,Water Chemistry (2002, pages 262-263).Dr. Benjamin is a civil and environmental
    engineering chemist at the U.of Washington

    Alk = *** The amount of a stung acid to titrate a solution to a preselected pH of near
    4.7............For this reason, the alkalinity is sometimes referred to as the acid
    neutralizing capacity (ANC) of the water, based on the assumption that once this capacity
    is used up, sever ecological effects become much more likely.***

    "ACIDITY IS the opposite of BASICITY. You are an idiot!

    "Ok, if that's what they think than they are wrong. I haven't read there
    books, I will take your word for it. If their logic is the same as yours,
    their WRONG as well."

    "I'm confusing 'Acidity' and 'Acidity' What? Ok, now I really think you
    are an idiot."


    This shows me how little about water chemistry you know with this statement or are you
    just trying to make all other chemists wrong and you wright, as that is real joke. All of
    the worlds most well know water chemists are wrong and you are right. Take note how you
    jumped to a conclusion without even lookin' or thinkin' of what you said, doesn't speak
    much of yourself. This will be one example, how many do I need and from how many water
    chemistry books do I need, to post or explain to you.

    ***Benjamin,Water Chemistry (2002, pages 262-263).***

    ***A concept that is exactly analogous to alkalinity but measures the base neutralizing
    capacity (BNC) of a solution is Acidity. The quantitative represents the concentration of
    OH- ions that must be added to titrate the solution to a pH near 10.5***

    So that means that not only in Benjamin wrong but, so are Stumm & Morgan, Millero, Pilosn,
    Riley & Chester, Pankow, Snoeyink & Jenkins, just to name a few. As I said, you have your
    acidity and Acidy mixed up. Acidity as defined above is covered in most water chemistry
    books, written by chemists, who's field of expertise is water chemistry. You can even buy
    Acidity test kits from, HACH, LaMotte, etc..

    Please explain where the HELL you get this idea from these guys are flipin' marine
    biologists. Do a dam search on them or shut the hell up. All of my ref but one are from
    chemists......PERIOD and most have been in their field for more than a decade and some for
    4 decades. And most of them teach chemistry and are professors of chemistry.Point one out
    that's not.There are NO marine biologist that have ever written a water chemistry book I
    collect them, it is a hobby of mine.

    Like I said you have your acidity and Acidity mixed up. You never asked to have me
    explain, as other chemists do, not familiar with water chemistry, just jump the gun and
    start the dam name calling. BUT I see you have apologized. I don't hold grudges, just like
    to have things straight. I also don't; mind me correct, I don't like giving out incorrect
    info..come to be correct, if needed. How about YOU. This hobby is plagued with myths and
    misconception and other things beside chemistry


    "> Christ, there you go again with the FW shit. All your numbers are wrong we
    are dealing
    > with SEAWATER


    You didn't say in your experiment that sea water was being used. The HH
    equation STILL applies"

    YOU, YOU keep posting pKa's for FW and are applying them to seawater, in YOUR examples.
    You can't use FW pKa's of Freshwater when dealing with seawater. I told you before they
    are not the same and are skewed to the left. NSW at @25 C and 35 ppt, are as given in my
    other post. pKa1= 6.00 and pKa 2 = 9.1.If you are going to be making calculations use the
    right pKa's. pKa's are a faction of salinity and temp. At least twice, YOU have used FW
    pKa's for seawater examples, need I point them out ? Here is just one

    "The pKa of CO3-2 is 10.3. Thus, at a pH of 8.3 (seawater for this example)
    you would have a 1 : 100 ratio of CO3-2 and HCO3-2. The equilibrium will
    be shifted to HCO3-2 by a ratio of 1:100"

    "Maybe you should send
    them an e-mail and tell them their web pages are wrong and that they are
    offending all the marine biologists across the country."

    More of your BS line. What marine biologists have I mentioned or posted, please show
    me.Their is acidy and basicty and there is Alkalinity and Acidity

    "Therefore, measuring alkalinity tells you something about your 'buffering
    capacity'.


    Yes, agreed. If you go back a check one of my post I said Millero said if you know the BC
    you can calculate the Alk. Matter of fact I believe he also said there was conversion for
    it. The only method we have to give us an idea of the buffering capacity is Alk. However,
    if you took Alk and Acidity you will have even a better idea for both up and down the
    scale


    "So when we measure ALKALINITY we are indirectly measuring BUFFERING
    CAPACITY.

    Because aquarium and sea water have other buffers in solution, you need to
    determine the BUFFERING INDEX for each buffer in solution"


    Yes, I would agree to that and is why I said BC isn't the same as Alk However, it is only
    telling us half of the story in regards to BC, nothing of the Acidity, which in most cases
    is something we don't need to worry about or even measure, as our problems 95 % of the
    times are falling pH and not rising pH ( but this does happen in systems high in
    plants/algae)

    I think that covers it for now


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    If You See Me Running You Better Catch-Up
     
    Boomer, Feb 11, 2004
    #49
  10. Dinky

    Boomer Guest

    Alkalinity a measure of the amount of anions of weak acid in water and of the cations
    balanced against them
    Take note it says ***acid***

    Buffering capacity the ability of a solution to resist or dampen changes in pH upon the
    addition of acids or bases.
    Take note its says ***the addition of acids or bases***

    One more

    http://www.waterontheweb.org/resources/glossary.html

    We could go on like this all day, so what is the point ?

    You will LOVE this one
    http://www.kyantec.com/Tips/phbuffering.htm

    Don't you just lovbe PDF's
    http://www.inform.umd.edu/manurenet/reprints/98.1702.pdf

    Don't fall out of your chair
    http://www.chemforlife.org/teacher/topics/chemistry_in_an_aquarium.htm




    --
    Boomer

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    If You See Me Running You Better Catch-Up
    "stoutman" <.@.> wrote in message news:XB7Wb.19339$QA2.62332@attbi_s52...
    : Man here is another, google is a wonderful thing. I'm not filtering any
    : out, just posting what I find by GOOGLING for you.
    :
    : http://www.globe.gov/hq/trr_suppl/hydro/HY_SUP_ALK_INTRO_NOTES.HTML
    :
    :
    : Wow, a gov link. Even the government is wrong, this must be a conspiracy
    : against Boomer.
    :
    :
    :
    :
    : "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    : news:102ht0bjplpo059@corp.supernews.com...
    : > Now I am getting bored
    : >
    : > "Don't the components of a buffer account for the buffering capacity?
    : Yes."
    : >
    : > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity and
    : Alkalinity are
    : > not the same, that has always been the issue. I gave the equation does
    : that look like an
    : > Alkalinity equation or how Alk is determined. I see you had now comments
    : on it what's
    : > wrong, why no comments on the equations I gave. Don't understand them or
    : what ? Again this
    : > is the equation for Buffering Capacity, also called Buffer Index or Buffer
    : Intensity. It
    : > is defined in most water chemistry and chemical oceanography text books.
    : >
    : > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa
    : [H3O+] / (Ka =
    : > H3O+])² )
    : >
    : > This is not Alkalinity now is it ?
    : >
    : > "I know how to do a titration, In fact I have done several. How many have
    : > you actually done? I don't mean by counting drops, I mean with a buret?"
    : >
    : > Well good for you, I use a Digital Titrator
    : >
    : > "Oh, I see,
    : > you think acidity is the opposite of alkalinity. In the world of
    : CHEMISTRY
    : > it's not. Maybe in aquarium newsgroups it is.
    : >
    : > Hum no, maybe you should go for a look at HACH's or LaMotte website or the
    : book I
    : > suggested earlier. Please view a copy.
    : >
    : > Standard Methods for the Examination of Water and Wastewater
    : >
    : > This book, over 2000 pages, is the guide for water testing. If you are
    : reporting water
    : > test to the EPA you must use approved std from this text.I t is prepared
    : and published by
    : > the EPA, American Water Works Association and American Public Health
    : Association. You
    : > mean you don't have one and the issue is water chemistry
    : >
    : > You are confusing Acidity and Acidity as you know little about water
    : chemistry and
    : > procedures and test methods
    : >
    : > From SMEWW, section 2-30, 2310 ACIDITY
    : >
    : > "Acidity of water is its quantative capacity to react with a strong base
    : to a designated
    : > pH"
    : >
    : > This is how you test for it
    : >
    : > A std alkali titration to methyl orange or phenolphthalein
    : > endpoint.
    : >
    : > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this
    : book, there are
    : > over 100 of them, they are wrong.
    : >
    : > Like Buffering Capacity you have your Acidity's mixed up
    : > In water measurement if you have a high Alk you also usually have a high
    : Acidity.
    : > Normally a high Alk also gives a higher CO2 level. Get a WATER CHEMISTRY
    : BOOK there pal.
    : >
    : >
    : > "These are all in equilibrium with each other. An initial high pH (above
    : > 6.4) will shift the equilibrium to the right to form HCO3-1. If the pH of
    : > the solution is above 10.3 (pKa2) the .........."
    : >
    : >
    : > Christ, there you go again with the FW shit. All your numbers are wrong we
    : are dealing
    : > with SEAWATER
    : >
    : > This means that at a pH of 8.3, the majority of the CO2(aq) is in the form
    : > of HCO3-1 .
    : >
    : > I have already pointed that out and gave actual values at know seawater
    : levels, go back
    : > and re-read it you aren't telling me anything here.Of course most is HCO3
    : see...
    : >
    : >
    : > @ 20C and 34.3 ppt salinity
    : >
    : > CO2 = 0.52 %
    : >
    : > HCO3 = 86.4 %
    : >
    : > CO3 = 13.09 %
    : >
    : >
    : > "In your glass experiment you managed to lower the pH enough to purge out
    : CO2
    : > by boiling"
    : >
    : > The purpose behind the glass is to show that alk is not affect by CO2 and
    : vise-versa and
    : > how Co2 affects pH.
    : >
    : > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH drops
    : to say 8.1 it is
    : > usually due to excess CO2. If you took a glass of that water and aerated
    : it you WILL drive
    : > off the CO2 and raise the pH. It has been done a proven a million times.
    : >
    : > "In order to 'purge' CO2 you would need to lower the
    : > pH to shift the equilibrium to below 6.4"
    : >
    : > The hell you do !!!.Do you know who many times people on this NG to
    : include Dr. Craig
    : > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a
    : sample of aquarium
    : > water and aerate it to see if the pH GOES UP AND when they come back with
    : the test it is
    : > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST excess
    : CO2 in the tank
    : > water, increase the circulation for better gas exchange at the surface,
    : reduce feeding,
    : > and try to improve on better skimming, thus reducing the bio-load and pH
    : decline due to
    : > CO2.
    : >
    : >
    : > "I hope this helps. "
    : >
    : > Help, how can you when you miss everything. I should be charging you
    : >
    : > Oh, by the way. Your websites, I have about 50 on these issues, I could
    : post them, not to
    : > mention I have all those water chemistry books, so there is no need to
    : view your sites.
    : >
    : > Finally are you afraid to come to our Chemistry Forum, afraid to get
    : slapped by REAL
    : > chemists. I get a charge out of you can't post your ref .I have posted the
    : same or similar
    : > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts
    : there and am the
    : > biggest contributor to his forum other than himself or maybe Habib Sheka
    : >
    : > Hum, here are Randy's ref that he posted. He hosts the website
    : >
    : > S. RANDY HOLMES-FARLEY
    : > Arlington, Massachusetts
    : >
    : > EDUCATION
    : >
    : > 1982-1986 Harvard University Cambridge, MA
    : > PhD in Chemistry
    : > Research Advisor: George Whitesides
    : >
    : > Investigated the relationship between polymer surface chemistry and
    : physical properties
    : > through controlled surface modification and testing.
    : >
    : > 1980-1982 Cornell University Ithaca, NY
    : > BA in Chemistry and Biology
    : > Graduated Summa Cum Laude
    : > Distinction in All Subjects
    : > Grade Point: 3.94/4.0
    : > Honors research: isolation and characterization of the subunit of CF1
    : enzyme
    : >
    : >
    : > 1978-1979 Stanford University Palo Alto, CA
    : > Grade Point: 3.55/4.0
    : >
    : >
    : > EXPERIENCE
    : >
    : > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    : > (bought out GelTex Pharmaceuticals in 2001)
    : > Vice President, Chemical Research 2001-present
    : > Senior Director, Chemical Research 1999-2001
    : > Director of Chemical Research 1997-1999
    : > Manager of Chemical Research 1995-1997
    : > Group Leader 1994-1995
    : > Senior Research Scientist 1992-1994
    : >
    : > Helped start GelTex as second employee
    : >
    : > Managed various research programs with multi-million dollar budgets
    : >
    : > Supervised research chemists (17+)
    : >
    : > Co-inventor of several polymeric pharmaceuticals and pharmaceutical
    : candidates including
    : > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride (FDA
    : approved)
    : >
    : > Company Safety Officer for 3 years
    : >
    : > Chemical Hygiene Officer 2000-present
    : >
    : >
    : >
    : >
    : > 1990-1992 GTE Corporation Waltham, MA
    : > Senior Member of Technical Staff
    : > Applied research involving polymer interfaces
    : > Metallization of plastics
    : > Polymer/polymer adhesion
    : > Optical coatings
    : >
    : >
    : >
    : > 1986-1990 Lord Corporation Cary, NC
    : > Senior Research Scientist 1988-1990
    : > Research Scientist 1986-1988
    : > Basic and applied research on surface chemical bonding
    : > Developed new adhesive compositions
    : > Developed new sol-gel coatings for corrosion resistance
    : >
    : >
    : > HONORS AND AWARDS
    : >
    : > Industrial Innovations Award by Northeast Region of American Chemical
    : Society (6/2001)
    : >
    : > National Kidney Foundation of Northern California Honoree (5/2001)
    : >
    : > American Chemical Society/Polymer Chemistry Division Industrial Sponsors
    : > Award (8/2000)
    : >
    : > R&D 100 Award from R&D magazine (1999)
    : >
    : > Sherwin Williams Award in applied polymer science (9/85)
    : >
    : > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    : >
    : > Award for highest GPA in Chemistry Department (6/82)
    : >
    : > Summa Cum Laude Honors in Chemistry (6/82)
    : >
    : > Phi Lamda Epsilon (6/82)
    : >
    : > Phi Beta Kappa (2/82)
    : >
    : > Cornell University Dean's List (1981, 1982)
    : >
    : > Harvard Book Club Award for highest GPA senior year (1978)
    : >
    : > First Place in western NY ACS high school chemistry exam (1977)
    : >
    : > 1978-1979
    : >
    : >
    : > __________________
    : > Randy Holmes-Farley
    : > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    : >
    : > Hobby Experience: 8 years with reefs
    : > Current Tanks: 90 gal mixed reef
    : > Interests: Reefkeeping, science, photography
    : >
    : >
    : > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    : >
    : > Open this post in a new window | Report this post to a moderator | IP:
    : Logged
    : >
    : >
    : >
    : > 06/27/2003 02:44 PM
    : >
    : > Randy Holmes-Farley
    : > Chemistry Moderator
    : >
    : > Registered: Apr 2001
    : > Location: Arlington, Massachusetts
    : > Occupation: Chemist (Drug Discovery at Genzyme)
    : > Posts: 15282
    : >
    : >
    : >
    : > Publications
    : >
    : >
    : > ISSUED UNITED STATES PATENTS
    : >
    : >
    : > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;
    : Mandeville, III; W. Harry.
    : > US 6,566,407; 5/20/2003
    : >
    : > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall;
    : Huval, Chad
    : > Cori.
    : > U.S. 6,517,825; 2/11/2003.
    : >
    : > 3. Method of making phosphate-binding polymers for oral administration.
    : Holmes-Farley,
    : > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.
    : 6,509,013; 1/21/2003.
    : >
    : > 4. Combination therapy for treating hypercholesterolemia using a bile acid
    : sequestrant
    : > polymer
    : > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen
    : Randall;
    : > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    : >
    : > 5. Method for treating hypercholesterolemia with polyallylamine polymers.
    : Holmes-Farley,
    : > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg,
    : Dennis I. , US
    : > 6,423,754; 7/23/2002.
    : >
    : > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;
    : Neenan, Thomas X..;
    : > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    : >
    : > 7. Combination therapy for treating hypercholesterolemia and
    : atherosclerosis. Huval, Chad
    : > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K.
    : U.S. 6,365,186;
    : > 4/2/2002.
    : >
    : > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville,
    : W. H., III;
    : > Huval; C.
    : > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;
    : 10/9/2001.
    : >
    : > 9. Polymers containing guanidinium groups as bile acid sequestrants. Dhal;
    : P. K.; Holmes-
    : > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    : >
    : > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,
    : III.; US
    : > 6,281,252;
    : > 8/28/2001.
    : >
    : > 11. Combination therapy for treating hypercholestrolemia. Huval; C. C.;
    : Holmes-Farley; S.
    : > R. ;
    : > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    : >
    : > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;
    : Holmes-Farley, S.
    : > R.; US
    : > 6,264,937; 7/24/2001.
    : >
    : > 13. Method for treating hypercholesterolemia with unsubstituted
    : polydiallylamine polymers.
    : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    : 6,248,318;
    : > 6/19/2001.
    : >
    : > 14. Process for removing bile salts from a patient and alkylated
    : compositions therefore.
    : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    : >
    : > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.;
    : Dhal, P. K.;
    : > Petersen,
    : > J. S.; US 6,203,785; 3/20/2001.
    : >
    : > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval,
    : C. C.; US
    : > 6,190,649;
    : > 2/20/2001.
    : >
    : > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,
    : III.; US
    : > 6,177,478;
    : > 1/23/2001.
    : >
    : > 18. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley,
    : S. R.;
    : > Mandeville, W.
    : > H., III.; US 6,129,910; 10/10/2000.
    : >
    : > 19. Method for treating hypercholesterolemia with unsubstituted
    : polydiallylamine polymers.
    : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    : 6,083,497;
    : > 7/4/2000.
    : >
    : > 20. Method of making phosphate-binding polymers for oral administration.
    : Holmes-Farley, S.
    : > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.
    : >
    : > 21. Process for removing bile salts from a patient and alkylated
    : compositions therefore.
    : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.
    : >
    : > 22. Process for removing bile salts from a patient and compositions
    : therefor. Mandeville,
    : > W. H.,
    : > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    : >
    : > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;
    : Neenan; T. X.; Holmes-
    : > Farley; S. R. US 6,034,129; 3/7/2000.
    : >
    : > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,
    : III.; US
    : > 5,985,938;
    : > 11/16/99.
    : >
    : > 25. Process for removing bile salts from a patient and compositions
    : therefor. Mandeville,
    : > W. H.,
    : > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    : >
    : > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H.,
    : III.;
    : > Holmes-Farley;
    : > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    : >
    : > 27. Hydrophilic nonamine-containing and amine-containing copolymers and
    : their use as bile
    : > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184;
    : 7/27/99.
    : >
    : > 28. Interpenetrating polymer networks for sequestration of bile acids.
    : Mandeville, W. H.,
    : > III.;
    : > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;
    : 7/20/99.
    : >
    : > 29. Amine polymer sequestrant and method of cholesterol depletion.
    : Mandeville, W. H.,
    : > III.;
    : > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    : >
    : > 30. Process for removing bile salts from a patient and compositions
    : therefor. Mandeville,
    : > W. H.,
    : > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    : >
    : > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.
    : Mandeville, W. H.,
    : > III.;
    : > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    : >
    : > 32. Process for removing bile salts from a patient and compositions
    : therefor. Mandeville,
    : > W. H.,
    : > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    : >
    : > 33. Preparation of polymeric sequestrants for bile acid salts. Mandeville,
    : W. H., III.;
    : > Holmes-
    : > Farley, S. R.; US 5,703,188; 12/30/97.
    : >
    : > 34. Oral administration of iron-binding crosslinked amine polymers.
    : Mandeville, W. H.,
    : > III.;
    : > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    : >
    : > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S.
    : R.; US 5,693,675;
    : > 12/2/97.
    : >
    : > 36. Method for removing bile salts from a patient with alkylated
    : crosslinked amine
    : > polymers,
    : > and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley,
    : S. R.; US
    : > 5,679,717; 10/21/97.
    : >
    : > 37. Phosphate-binding polymers for oral administration. Holmes-Farley, S.
    : R.; Mandeville,
    : > W.
    : > H., III.; US 5,667,775; 9/16/97.
    : >
    : > 38. Ion-exchange process using highly crosslinked polymers for removing
    : bile salts from a
    : > patient, preparation of the polymers, and compositions containing them.
    : Mandeville, W. H.,
    : > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    : >
    : > 39. Hydrophobic amine polymer sequestrant and method of cholesterol
    : depletion. Mandeville,
    : > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.
    : >
    : > 40. Amine polymer sequestrant and method of cholesterol depletion.
    : Mandeville, W. H.,
    : > III.;
    : > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    : >
    : > 41. Phosphate-binding polymers for oral administration. Holmes-Farley, S.
    : R.; Mandeville,
    : > W.
    : > H., III.; US 5,496,545; 3/5/96.
    : >
    : > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,
    : III.; Holmes-Farley,
    : > S. R.;
    : > US 5,487,888; 1/30/96.
    : >
    : > 43. Ultra-thin, uniform sol-gel coating of a substrate having active
    : hydrogens on the
    : > surface.
    : > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    : >
    : > 44. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley,
    : S. R.; Yanyo, L.
    : > C.;
    : > US 5,182,143; 1/26/93.
    : >
    : > 45. Method for metal bonding using ultrathin primer coating.
    : Holmes-Farley, S. R.; Yanyo,
    : > L.
    : > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    : >
    : > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US
    : 5,096,962;
    : > 3/17/92.
    : >
    : > 47. Modified halogenatedpolyolefin adhesives for polyolefin
    : elastomer-metal bonding.
    : > Holmes-
    : > Farley, S. R.; US 5,102,956; 4/7/92.
    : >
    : >
    : >
    : > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    : >
    : >
    : > 1. Aryl boronate functionalized polymers for treating obesity and
    : inhibiting fat uptake.
    : > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal, Pradeep
    : K.; Huval, Chad
    : > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92 pp. WO
    : 0302571.
    : >
    : > 2. Preparation of aryl boronic acids for treating obesity. Holmes-Farley,
    : Stephen Randall;
    : > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep K.
    : (Geltex
    : > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    : >
    : > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,
    : Stephen Randall.
    : > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO
    : 0302130.
    : >
    : > 4. Method for reducing copper levels and treating copper toxicosis.
    : Holmes-Farley, Stephen
    : > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45
    : pp. WO
    : > 0285383.
    : >
    : > 5. Method for treating gout and binding uric acid. Holmes-Farley, Stephen
    : Randall; Burke,
    : > Steven K. WO 0285381 10/31/2002.
    : >
    : > 6. Method for treating gout and reducing serum uric acid. Holmes-Farley,
    : Stephen Randall;
    : > Burke, Steven K WO 0285380 10/31/2002.
    : >
    : > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;
    : Holmes-Farley, S. R.;
    : > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    : >
    : > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and
    : Holmes-Farley, S.
    : > R.;
    : > WO 1999-US5662; 9/23/1999.
    : >
    : > 9. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley,
    : S. R.; Petersen,
    : > J. S.;
    : > WO 9933452; 7/8/1999.
    : >
    : > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and
    : Holmes-Farley, S.
    : > R.;
    : > WO 9922743; 5/14/1999.
    : >
    : > 11. Polyallylamine polymers for removing bile salts and treating
    : hypercholesterolemia, and
    : > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke,
    : S. K.; Goldberg,
    : > D. I.; WO 9857652; 12/23/98.
    : >
    : > 12. Phosphate-bidning polymers combined with a calcium supplement for oral
    : administration.
    : > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S.
    : R.; WO 9842355;
    : > 10/1/98.
    : >
    : > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol
    : depletion. Mandeville,
    : > W.
    : > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    : >
    : > 14. Process for adjusting ion concentration in a patient and compositions
    : therefor.
    : > Mandeville,
    : > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    : >
    : > 15. Vacuum-deposited silver on polycarbonate with a chromium interlayer
    : for improved
    : > metal-
    : > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.
    : >
    : > 16. Process for increased metal-substrate bond strength in metalized
    : plastics.
    : > Holmes-Farley, S.
    : > R.; Ger. Offen. 4322516; 7/6/93.
    : >
    : > 17. Electrorheological fluids and preparation of particles useful in the
    : fluids.
    : > Troughton,
    : > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.
    : David; Bares, Joseph
    : > E.;
    : > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP
    : 394049;
    : > 10/24/1990.
    : >
    : > JOURNAL PUBLICATIONS
    : >
    : > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene;
    : Guo, Amy;
    : > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;
    : Mandeville, W. Harry;
    : > Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.
    : >
    : > 2. Amine functionalized polyethers as bile acid sequestrants: synthesis
    : and biological
    : > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall;
    : Mandeville, W.
    : > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.
    : Journal of
    : > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),
    : 1559-1574.
    : >
    : > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular
    : Imprinting. Huval,
    : > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.
    : Randall; Mandeville,
    : > W.
    : > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.;
    : Chen, Xi; Dhal,
    : > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    : >
    : > 4. Synthetic polymers for the binding of fat in the intestinal tract.
    : Jozefiak, Thomas H.;
    : > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval,
    : Chad C.;
    : > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.
    : Abstracts of
    : > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August
    : 26-30, 2001
    : > (2001), POLY-047 and Polymer Preprints (American Chemical Society,
    : Division of
    : > Polymer Chemistry) (2001), 42(2), 98.
    : >
    : > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel
    : pharmaceutical.
    : > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward,
    : J.; Sacchiero,
    : > B.;
    : > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen,
    : X.; Mazzeo, J.
    : > R.. Polym. Preprints (2000), 41(1), 735-736.
    : >
    : > 6. In vitro comparison of bile acid binding to colesevelam HCl and other
    : bile acid
    : > sequestrants.
    : > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;
    : Hook, P.; Holmes-
    : > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    : >
    : > 7. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley,
    : S. R; Polym.
    : > Mater. Sci. Eng (1999), 80, 246-247.
    : >
    : > 8. Design and characterization of of Sevelamer Hydrochloride: a novel
    : phosphate-binding
    : > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.;
    : Miller, K. L.;
    : > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and
    : Appl. Chem.,
    : > A36(7&8), p. 1085 (1999).
    : >
    : > 9. Three generations of bile acid sequestrants. Mandeville, W. H., III;
    : Braunlin, W.;
    : > Dhal, P.;
    : > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;
    : Rosenbaum, D.;
    : > Sacchiero,
    : > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),
    : 550, 3-15.
    : >
    : > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate
    : binder, on
    : > urinary
    : > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;
    : Mandeville, W. H.,
    : > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.
    : (1997), 12(5)
    : > 961-964.
    : >
    : > 11. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley,
    : S. R.; Yanyo, L.
    : > C;
    : > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.
    : >
    : > 12. The mechanism of cure initiation of a surface activated adhesive.
    : Holmes-Farley, S.
    : > R.;
    : > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    : >
    : > 13. Adhesion promotion and corrosion prevention using thin anisotropic
    : coatings. Holmes-
    : > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),
    : 131-151.
    : >
    : > 14. Wetting of functionalized polyethylene having ionizable organic acids
    : and bases at the
    : > polymer-water interface: relations between functional group polarity,
    : extent of
    : > ionization,
    : > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;
    : Whitesides, G. M.;
    : > Langmuir
    : > (1988), 4(4), 921-937.
    : >
    : > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a
    : single hydroxy group.
    : > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    : >
    : > 16. Reconstruction of the interface of oxidatively functionalized
    : polyethylene (PE-CO2H)
    : > and
    : > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.;
    : McCarthy, T. J.;
    : > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987),
    : AD-
    : > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    : >
    : > 17. Surface-modified polyethylene film: the relationship between surface
    : chemistry and
    : > physical
    : > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.
    : >
    : > 18. Reactivity of carboxylic acid and ester groups in the functionalized
    : interfacial
    : > region of
    : > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:
    : differentiation of the
    : > functional groups into shallow and deep subsets based on a comparison of
    : contact angle and
    : > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir
    : (1987), 3(1), 62-
    : > 76.
    : >
    : > 19. Fluorescence properties of dansyl groups covalently bonded tot he
    : surface of
    : > oxidatively
    : > functionalized low-density polyethylene film. Holmes-Farley, S. R.;
    : Whitesides, G. M.;
    : > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;
    : AD-A162435/2/GAR,
    : > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    : >
    : > 20. Acid-base behavior of carboxylic acid groups covalently attached at
    : the surface of
    : > polyethylene: The usefulness of contact angle in following the ionization
    : of surface
    : > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;
    : Deutch, J.;
    : > Whitesides,
    : > G. M.; Langmuir (1985), 1(6), 725-740.
    : >
    : > 21. The thermal stability of a surface modified solid organic polymer.
    : Holmes-Farley, S.
    : > R.;
    : > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    : >
    : >
    : >
    : > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    : >
    : > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced
    : Aquarist. June 2003.
    : >
    : > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.
    : Advanced Aquarist.
    : > May
    : > 2003.
    : >
    : > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.
    : Reefkeeping May
    : > 2003.
    : >
    : > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping
    : April 2003.
    : >
    : > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    : Holmes-Farley, R.
    : > Advanced Aquarist; April 2003.
    : >
    : > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    : Holmes-Farley, R.
    : > Advanced Aquarist; April 2003.
    : >
    : > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced Aquarist;
    : March 2003.
    : >
    : > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.
    : Holmes-Farley, R.
    : > Advanced Aquarist; February 2003.
    : >
    : > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January
    : 2003.
    : >
    : > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; December
    : 2002.
    : >
    : > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R. Advanced
    : Aquarist; November
    : > 2002.
    : >
    : > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.
    : Advanced Aquarist;
    : > November 2002.
    : >
    : > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced Aquarist,
    : September 2002.
    : >
    : > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August
    : 2002.
    : >
    : > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April
    : 2002.
    : >
    : > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced
    : Aquarist; July 2002
    : >
    : > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist; June
    : 2002.
    : >
    : > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R. Advanced
    : Aquarist, May
    : > 2002.
    : >
    : > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.
    : Holmes-Farley, R.
    : > Advanced Aquarist, April 2002.
    : >
    : > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    : >
    : > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    : >
    : > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January 2002.
    : >
    : > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers
    : 2000.
    : >
    : > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium
    : Frontiers 2000.
    : >
    : > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.
    : Aquarium Frontiers
    : > 2000.
    : > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium Frontiers
    : 2000.
    : >
    : > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers 2000.
    : >
    : > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    : >
    : > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    : >
    : >
    : >
    : >
    : >
    : >
    : >
    : > Boomer
    : >
    : > Want to talk chemistry ? The Reef Chemistry Forum
    : > http://www.reefcentral.com/vbulletin/index.php
    : >
    : > Want to See More ?
    : > Please Join Our Growing Membership
    : > www.coralrealm.com
    : >
    : >
    : >
    :
    :
     
    Boomer, Feb 11, 2004
    #50
  11. "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102kk02ji5nc606@corp.supernews.com...


    > Do a dam search on them or shut the hell up.


    I'll second that.

    kc
     
    Dragon Slayer, Feb 11, 2004
    #51
  12. Dinky

    Boomer Guest

    Dam, how did I forget my favorite book

    Carbon Dioxide Equilibrium and Their Applications by J.N. Butler (professor emeritus
    Harvard University)


    You should really look for a copy of this master piece. Page 67 has a pC/pH diagram of
    BC's for FW. He also gives the long mathematically expression of Alkalinity. His review of
    Acidity is rather short though but long on Alk. 5 pages of BC
    --
    Boomer

    Want to talk chemistry ? The Reef Chemistry Forum
    http://www.reefcentral.com/vbulletin/index.php

    Want to See More ?
    Please Join Our Growing Membership
    www.coralrealm.com

    If You See Me Running You Better Catch-Up
    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102kn4e6f2vvb1@corp.supernews.com...
    : Alkalinity a measure of the amount of anions of weak acid in water and of the cations
    : balanced against them
    : Take note it says ***acid***
    :
    : Buffering capacity the ability of a solution to resist or dampen changes in pH upon the
    : addition of acids or bases.
    : Take note its says ***the addition of acids or bases***
    :
    : One more
    :
    : http://www.waterontheweb.org/resources/glossary.html
    :
    : We could go on like this all day, so what is the point ?
    :
    : You will LOVE this one
    : http://www.kyantec.com/Tips/phbuffering.htm
    :
    : Don't you just lovbe PDF's
    : http://www.inform.umd.edu/manurenet/reprints/98.1702.pdf
    :
    : Don't fall out of your chair
    : http://www.chemforlife.org/teacher/topics/chemistry_in_an_aquarium.htm
    :
    :
    :
    :
    : --
    : Boomer
    :
    : Want to talk chemistry ? The Reef Chemistry Forum
    : http://www.reefcentral.com/vbulletin/index.php
    :
    : Want to See More ?
    : Please Join Our Growing Membership
    : www.coralrealm.com
    :
    : If You See Me Running You Better Catch-Up
    : "stoutman" <.@.> wrote in message news:XB7Wb.19339$QA2.62332@attbi_s52...
    : : Man here is another, google is a wonderful thing. I'm not filtering any
    : : out, just posting what I find by GOOGLING for you.
    : :
    : : http://www.globe.gov/hq/trr_suppl/hydro/HY_SUP_ALK_INTRO_NOTES.HTML
    : :
    : :
    : : Wow, a gov link. Even the government is wrong, this must be a conspiracy
    : : against Boomer.
    : :
    : :
    : :
    : :
    : : "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    : : news:102ht0bjplpo059@corp.supernews.com...
    : : > Now I am getting bored
    : : >
    : : > "Don't the components of a buffer account for the buffering capacity?
    : : Yes."
    : : >
    : : > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity and
    : : Alkalinity are
    : : > not the same, that has always been the issue. I gave the equation does
    : : that look like an
    : : > Alkalinity equation or how Alk is determined. I see you had now comments
    : : on it what's
    : : > wrong, why no comments on the equations I gave. Don't understand them or
    : : what ? Again this
    : : > is the equation for Buffering Capacity, also called Buffer Index or Buffer
    : : Intensity. It
    : : > is defined in most water chemistry and chemical oceanography text books.
    : : >
    : : > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] + CKa
    : : [H3O+] / (Ka =
    : : > H3O+])² )
    : : >
    : : > This is not Alkalinity now is it ?
    : : >
    : : > "I know how to do a titration, In fact I have done several. How many have
    : : > you actually done? I don't mean by counting drops, I mean with a buret?"
    : : >
    : : > Well good for you, I use a Digital Titrator
    : : >
    : : > "Oh, I see,
    : : > you think acidity is the opposite of alkalinity. In the world of
    : : CHEMISTRY
    : : > it's not. Maybe in aquarium newsgroups it is.
    : : >
    : : > Hum no, maybe you should go for a look at HACH's or LaMotte website or the
    : : book I
    : : > suggested earlier. Please view a copy.
    : : >
    : : > Standard Methods for the Examination of Water and Wastewater
    : : >
    : : > This book, over 2000 pages, is the guide for water testing. If you are
    : : reporting water
    : : > test to the EPA you must use approved std from this text.I t is prepared
    : : and published by
    : : > the EPA, American Water Works Association and American Public Health
    : : Association. You
    : : > mean you don't have one and the issue is water chemistry
    : : >
    : : > You are confusing Acidity and Acidity as you know little about water
    : : chemistry and
    : : > procedures and test methods
    : : >
    : : > From SMEWW, section 2-30, 2310 ACIDITY
    : : >
    : : > "Acidity of water is its quantative capacity to react with a strong base
    : : to a designated
    : : > pH"
    : : >
    : : > This is how you test for it
    : : >
    : : > A std alkali titration to methyl orange or phenolphthalein
    : : > endpoint.
    : : >
    : : > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write this
    : : book, there are
    : : > over 100 of them, they are wrong.
    : : >
    : : > Like Buffering Capacity you have your Acidity's mixed up
    : : > In water measurement if you have a high Alk you also usually have a high
    : : Acidity.
    : : > Normally a high Alk also gives a higher CO2 level. Get a WATER CHEMISTRY
    : : BOOK there pal.
    : : >
    : : >
    : : > "These are all in equilibrium with each other. An initial high pH (above
    : : > 6.4) will shift the equilibrium to the right to form HCO3-1. If the pH of
    : : > the solution is above 10.3 (pKa2) the .........."
    : : >
    : : >
    : : > Christ, there you go again with the FW shit. All your numbers are wrong we
    : : are dealing
    : : > with SEAWATER
    : : >
    : : > This means that at a pH of 8.3, the majority of the CO2(aq) is in the form
    : : > of HCO3-1 .
    : : >
    : : > I have already pointed that out and gave actual values at know seawater
    : : levels, go back
    : : > and re-read it you aren't telling me anything here.Of course most is HCO3
    : : see...
    : : >
    : : >
    : : > @ 20C and 34.3 ppt salinity
    : : >
    : : > CO2 = 0.52 %
    : : >
    : : > HCO3 = 86.4 %
    : : >
    : : > CO3 = 13.09 %
    : : >
    : : >
    : : > "In your glass experiment you managed to lower the pH enough to purge out
    : : CO2
    : : > by boiling"
    : : >
    : : > The purpose behind the glass is to show that alk is not affect by CO2 and
    : : vise-versa and
    : : > how Co2 affects pH.
    : : >
    : : > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH drops
    : : to say 8.1 it is
    : : > usually due to excess CO2. If you took a glass of that water and aerated
    : : it you WILL drive
    : : > off the CO2 and raise the pH. It has been done a proven a million times.
    : : >
    : : > "In order to 'purge' CO2 you would need to lower the
    : : > pH to shift the equilibrium to below 6.4"
    : : >
    : : > The hell you do !!!.Do you know who many times people on this NG to
    : : include Dr. Craig
    : : > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a
    : : sample of aquarium
    : : > water and aerate it to see if the pH GOES UP AND when they come back with
    : : the test it is
    : : > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST excess
    : : CO2 in the tank
    : : > water, increase the circulation for better gas exchange at the surface,
    : : reduce feeding,
    : : > and try to improve on better skimming, thus reducing the bio-load and pH
    : : decline due to
    : : > CO2.
    : : >
    : : >
    : : > "I hope this helps. "
    : : >
    : : > Help, how can you when you miss everything. I should be charging you
    : : >
    : : > Oh, by the way. Your websites, I have about 50 on these issues, I could
    : : post them, not to
    : : > mention I have all those water chemistry books, so there is no need to
    : : view your sites.
    : : >
    : : > Finally are you afraid to come to our Chemistry Forum, afraid to get
    : : slapped by REAL
    : : > chemists. I get a charge out of you can't post your ref .I have posted the
    : : same or similar
    : : > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500 posts
    : : there and am the
    : : > biggest contributor to his forum other than himself or maybe Habib Sheka
    : : >
    : : > Hum, here are Randy's ref that he posted. He hosts the website
    : : >
    : : > S. RANDY HOLMES-FARLEY
    : : > Arlington, Massachusetts
    : : >
    : : > EDUCATION
    : : >
    : : > 1982-1986 Harvard University Cambridge, MA
    : : > PhD in Chemistry
    : : > Research Advisor: George Whitesides
    : : >
    : : > Investigated the relationship between polymer surface chemistry and
    : : physical properties
    : : > through controlled surface modification and testing.
    : : >
    : : > 1980-1982 Cornell University Ithaca, NY
    : : > BA in Chemistry and Biology
    : : > Graduated Summa Cum Laude
    : : > Distinction in All Subjects
    : : > Grade Point: 3.94/4.0
    : : > Honors research: isolation and characterization of the subunit of CF1
    : : enzyme
    : : >
    : : >
    : : > 1978-1979 Stanford University Palo Alto, CA
    : : > Grade Point: 3.55/4.0
    : : >
    : : >
    : : > EXPERIENCE
    : : >
    : : > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    : : > (bought out GelTex Pharmaceuticals in 2001)
    : : > Vice President, Chemical Research 2001-present
    : : > Senior Director, Chemical Research 1999-2001
    : : > Director of Chemical Research 1997-1999
    : : > Manager of Chemical Research 1995-1997
    : : > Group Leader 1994-1995
    : : > Senior Research Scientist 1992-1994
    : : >
    : : > Helped start GelTex as second employee
    : : >
    : : > Managed various research programs with multi-million dollar budgets
    : : >
    : : > Supervised research chemists (17+)
    : : >
    : : > Co-inventor of several polymeric pharmaceuticals and pharmaceutical
    : : candidates including
    : : > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride (FDA
    : : approved)
    : : >
    : : > Company Safety Officer for 3 years
    : : >
    : : > Chemical Hygiene Officer 2000-present
    : : >
    : : >
    : : >
    : : >
    : : > 1990-1992 GTE Corporation Waltham, MA
    : : > Senior Member of Technical Staff
    : : > Applied research involving polymer interfaces
    : : > Metallization of plastics
    : : > Polymer/polymer adhesion
    : : > Optical coatings
    : : >
    : : >
    : : >
    : : > 1986-1990 Lord Corporation Cary, NC
    : : > Senior Research Scientist 1988-1990
    : : > Research Scientist 1986-1988
    : : > Basic and applied research on surface chemical bonding
    : : > Developed new adhesive compositions
    : : > Developed new sol-gel coatings for corrosion resistance
    : : >
    : : >
    : : > HONORS AND AWARDS
    : : >
    : : > Industrial Innovations Award by Northeast Region of American Chemical
    : : Society (6/2001)
    : : >
    : : > National Kidney Foundation of Northern California Honoree (5/2001)
    : : >
    : : > American Chemical Society/Polymer Chemistry Division Industrial Sponsors
    : : > Award (8/2000)
    : : >
    : : > R&D 100 Award from R&D magazine (1999)
    : : >
    : : > Sherwin Williams Award in applied polymer science (9/85)
    : : >
    : : > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    : : >
    : : > Award for highest GPA in Chemistry Department (6/82)
    : : >
    : : > Summa Cum Laude Honors in Chemistry (6/82)
    : : >
    : : > Phi Lamda Epsilon (6/82)
    : : >
    : : > Phi Beta Kappa (2/82)
    : : >
    : : > Cornell University Dean's List (1981, 1982)
    : : >
    : : > Harvard Book Club Award for highest GPA senior year (1978)
    : : >
    : : > First Place in western NY ACS high school chemistry exam (1977)
    : : >
    : : > 1978-1979
    : : >
    : : >
    : : > __________________
    : : > Randy Holmes-Farley
    : : > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    : : >
    : : > Hobby Experience: 8 years with reefs
    : : > Current Tanks: 90 gal mixed reef
    : : > Interests: Reefkeeping, science, photography
    : : >
    : : >
    : : > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    : : >
    : : > Open this post in a new window | Report this post to a moderator | IP:
    : : Logged
    : : >
    : : >
    : : >
    : : > 06/27/2003 02:44 PM
    : : >
    : : > Randy Holmes-Farley
    : : > Chemistry Moderator
    : : >
    : : > Registered: Apr 2001
    : : > Location: Arlington, Massachusetts
    : : > Occupation: Chemist (Drug Discovery at Genzyme)
    : : > Posts: 15282
    : : >
    : : >
    : : >
    : : > Publications
    : : >
    : : >
    : : > ISSUED UNITED STATES PATENTS
    : : >
    : : >
    : : > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;
    : : Mandeville, III; W. Harry.
    : : > US 6,566,407; 5/20/2003
    : : >
    : : > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall;
    : : Huval, Chad
    : : > Cori.
    : : > U.S. 6,517,825; 2/11/2003.
    : : >
    : : > 3. Method of making phosphate-binding polymers for oral administration.
    : : Holmes-Farley,
    : : > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.
    : : 6,509,013; 1/21/2003.
    : : >
    : : > 4. Combination therapy for treating hypercholesterolemia using a bile acid
    : : sequestrant
    : : > polymer
    : : > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen
    : : Randall;
    : : > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    : : >
    : : > 5. Method for treating hypercholesterolemia with polyallylamine polymers.
    : : Holmes-Farley,
    : : > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg,
    : : Dennis I. , US
    : : > 6,423,754; 7/23/2002.
    : : >
    : : > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;
    : : Neenan, Thomas X..;
    : : > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    : : >
    : : > 7. Combination therapy for treating hypercholesterolemia and
    : : atherosclerosis. Huval, Chad
    : : > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K.
    : : U.S. 6,365,186;
    : : > 4/2/2002.
    : : >
    : : > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville,
    : : W. H., III;
    : : > Huval; C.
    : : > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;
    : : 10/9/2001.
    : : >
    : : > 9. Polymers containing guanidinium groups as bile acid sequestrants. Dhal;
    : : P. K.; Holmes-
    : : > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    : : >
    : : > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,
    : : III.; US
    : : > 6,281,252;
    : : > 8/28/2001.
    : : >
    : : > 11. Combination therapy for treating hypercholestrolemia. Huval; C. C.;
    : : Holmes-Farley; S.
    : : > R. ;
    : : > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    : : >
    : : > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;
    : : Holmes-Farley, S.
    : : > R.; US
    : : > 6,264,937; 7/24/2001.
    : : >
    : : > 13. Method for treating hypercholesterolemia with unsubstituted
    : : polydiallylamine polymers.
    : : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    : : 6,248,318;
    : : > 6/19/2001.
    : : >
    : : > 14. Process for removing bile salts from a patient and alkylated
    : : compositions therefore.
    : : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    : : >
    : : > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.;
    : : Dhal, P. K.;
    : : > Petersen,
    : : > J. S.; US 6,203,785; 3/20/2001.
    : : >
    : : > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval,
    : : C. C.; US
    : : > 6,190,649;
    : : > 2/20/2001.
    : : >
    : : > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,
    : : III.; US
    : : > 6,177,478;
    : : > 1/23/2001.
    : : >
    : : > 18. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley,
    : : S. R.;
    : : > Mandeville, W.
    : : > H., III.; US 6,129,910; 10/10/2000.
    : : >
    : : > 19. Method for treating hypercholesterolemia with unsubstituted
    : : polydiallylamine polymers.
    : : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    : : 6,083,497;
    : : > 7/4/2000.
    : : >
    : : > 20. Method of making phosphate-binding polymers for oral administration.
    : : Holmes-Farley, S.
    : : > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.
    : : >
    : : > 21. Process for removing bile salts from a patient and alkylated
    : : compositions therefore.
    : : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.
    : : >
    : : > 22. Process for removing bile salts from a patient and compositions
    : : therefor. Mandeville,
    : : > W. H.,
    : : > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    : : >
    : : > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;
    : : Neenan; T. X.; Holmes-
    : : > Farley; S. R. US 6,034,129; 3/7/2000.
    : : >
    : : > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H.,
    : : III.; US
    : : > 5,985,938;
    : : > 11/16/99.
    : : >
    : : > 25. Process for removing bile salts from a patient and compositions
    : : therefor. Mandeville,
    : : > W. H.,
    : : > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    : : >
    : : > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H.,
    : : III.;
    : : > Holmes-Farley;
    : : > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    : : >
    : : > 27. Hydrophilic nonamine-containing and amine-containing copolymers and
    : : their use as bile
    : : > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184;
    : : 7/27/99.
    : : >
    : : > 28. Interpenetrating polymer networks for sequestration of bile acids.
    : : Mandeville, W. H.,
    : : > III.;
    : : > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;
    : : 7/20/99.
    : : >
    : : > 29. Amine polymer sequestrant and method of cholesterol depletion.
    : : Mandeville, W. H.,
    : : > III.;
    : : > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    : : >
    : : > 30. Process for removing bile salts from a patient and compositions
    : : therefor. Mandeville,
    : : > W. H.,
    : : > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    : : >
    : : > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.
    : : Mandeville, W. H.,
    : : > III.;
    : : > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    : : >
    : : > 32. Process for removing bile salts from a patient and compositions
    : : therefor. Mandeville,
    : : > W. H.,
    : : > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    : : >
    : : > 33. Preparation of polymeric sequestrants for bile acid salts. Mandeville,
    : : W. H., III.;
    : : > Holmes-
    : : > Farley, S. R.; US 5,703,188; 12/30/97.
    : : >
    : : > 34. Oral administration of iron-binding crosslinked amine polymers.
    : : Mandeville, W. H.,
    : : > III.;
    : : > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    : : >
    : : > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S.
    : : R.; US 5,693,675;
    : : > 12/2/97.
    : : >
    : : > 36. Method for removing bile salts from a patient with alkylated
    : : crosslinked amine
    : : > polymers,
    : : > and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley,
    : : S. R.; US
    : : > 5,679,717; 10/21/97.
    : : >
    : : > 37. Phosphate-binding polymers for oral administration. Holmes-Farley, S.
    : : R.; Mandeville,
    : : > W.
    : : > H., III.; US 5,667,775; 9/16/97.
    : : >
    : : > 38. Ion-exchange process using highly crosslinked polymers for removing
    : : bile salts from a
    : : > patient, preparation of the polymers, and compositions containing them.
    : : Mandeville, W. H.,
    : : > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    : : >
    : : > 39. Hydrophobic amine polymer sequestrant and method of cholesterol
    : : depletion. Mandeville,
    : : > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.
    : : >
    : : > 40. Amine polymer sequestrant and method of cholesterol depletion.
    : : Mandeville, W. H.,
    : : > III.;
    : : > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    : : >
    : : > 41. Phosphate-binding polymers for oral administration. Holmes-Farley, S.
    : : R.; Mandeville,
    : : > W.
    : : > H., III.; US 5,496,545; 3/5/96.
    : : >
    : : > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,
    : : III.; Holmes-Farley,
    : : > S. R.;
    : : > US 5,487,888; 1/30/96.
    : : >
    : : > 43. Ultra-thin, uniform sol-gel coating of a substrate having active
    : : hydrogens on the
    : : > surface.
    : : > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    : : >
    : : > 44. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley,
    : : S. R.; Yanyo, L.
    : : > C.;
    : : > US 5,182,143; 1/26/93.
    : : >
    : : > 45. Method for metal bonding using ultrathin primer coating.
    : : Holmes-Farley, S. R.; Yanyo,
    : : > L.
    : : > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    : : >
    : : > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US
    : : 5,096,962;
    : : > 3/17/92.
    : : >
    : : > 47. Modified halogenatedpolyolefin adhesives for polyolefin
    : : elastomer-metal bonding.
    : : > Holmes-
    : : > Farley, S. R.; US 5,102,956; 4/7/92.
    : : >
    : : >
    : : >
    : : > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    : : >
    : : >
    : : > 1. Aryl boronate functionalized polymers for treating obesity and
    : : inhibiting fat uptake.
    : : > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal, Pradeep
    : : K.; Huval, Chad
    : : > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92 pp. WO
    : : 0302571.
    : : >
    : : > 2. Preparation of aryl boronic acids for treating obesity. Holmes-Farley,
    : : Stephen Randall;
    : : > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep K.
    : : (Geltex
    : : > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    : : >
    : : > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,
    : : Stephen Randall.
    : : > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO
    : : 0302130.
    : : >
    : : > 4. Method for reducing copper levels and treating copper toxicosis.
    : : Holmes-Farley, Stephen
    : : > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45
    : : pp. WO
    : : > 0285383.
    : : >
    : : > 5. Method for treating gout and binding uric acid. Holmes-Farley, Stephen
    : : Randall; Burke,
    : : > Steven K. WO 0285381 10/31/2002.
    : : >
    : : > 6. Method for treating gout and reducing serum uric acid. Holmes-Farley,
    : : Stephen Randall;
    : : > Burke, Steven K WO 0285380 10/31/2002.
    : : >
    : : > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;
    : : Holmes-Farley, S. R.;
    : : > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    : : >
    : : > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and
    : : Holmes-Farley, S.
    : : > R.;
    : : > WO 1999-US5662; 9/23/1999.
    : : >
    : : > 9. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley,
    : : S. R.; Petersen,
    : : > J. S.;
    : : > WO 9933452; 7/8/1999.
    : : >
    : : > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and
    : : Holmes-Farley, S.
    : : > R.;
    : : > WO 9922743; 5/14/1999.
    : : >
    : : > 11. Polyallylamine polymers for removing bile salts and treating
    : : hypercholesterolemia, and
    : : > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke,
    : : S. K.; Goldberg,
    : : > D. I.; WO 9857652; 12/23/98.
    : : >
    : : > 12. Phosphate-bidning polymers combined with a calcium supplement for oral
    : : administration.
    : : > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S.
    : : R.; WO 9842355;
    : : > 10/1/98.
    : : >
    : : > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol
    : : depletion. Mandeville,
    : : > W.
    : : > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    : : >
    : : > 14. Process for adjusting ion concentration in a patient and compositions
    : : therefor.
    : : > Mandeville,
    : : > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    : : >
    : : > 15. Vacuum-deposited silver on polycarbonate with a chromium interlayer
    : : for improved
    : : > metal-
    : : > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.
    : : >
    : : > 16. Process for increased metal-substrate bond strength in metalized
    : : plastics.
    : : > Holmes-Farley, S.
    : : > R.; Ger. Offen. 4322516; 7/6/93.
    : : >
    : : > 17. Electrorheological fluids and preparation of particles useful in the
    : : fluids.
    : : > Troughton,
    : : > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.
    : : David; Bares, Joseph
    : : > E.;
    : : > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP
    : : 394049;
    : : > 10/24/1990.
    : : >
    : : > JOURNAL PUBLICATIONS
    : : >
    : : > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene;
    : : Guo, Amy;
    : : > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;
    : : Mandeville, W. Harry;
    : : > Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.
    : : >
    : : > 2. Amine functionalized polyethers as bile acid sequestrants: synthesis
    : : and biological
    : : > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall;
    : : Mandeville, W.
    : : > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.
    : : Journal of
    : : > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),
    : : 1559-1574.
    : : >
    : : > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular
    : : Imprinting. Huval,
    : : > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.
    : : Randall; Mandeville,
    : : > W.
    : : > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.;
    : : Chen, Xi; Dhal,
    : : > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    : : >
    : : > 4. Synthetic polymers for the binding of fat in the intestinal tract.
    : : Jozefiak, Thomas H.;
    : : > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval,
    : : Chad C.;
    : : > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.
    : : Abstracts of
    : : > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August
    : : 26-30, 2001
    : : > (2001), POLY-047 and Polymer Preprints (American Chemical Society,
    : : Division of
    : : > Polymer Chemistry) (2001), 42(2), 98.
    : : >
    : : > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel
    : : pharmaceutical.
    : : > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward,
    : : J.; Sacchiero,
    : : > B.;
    : : > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen,
    : : X.; Mazzeo, J.
    : : > R.. Polym. Preprints (2000), 41(1), 735-736.
    : : >
    : : > 6. In vitro comparison of bile acid binding to colesevelam HCl and other
    : : bile acid
    : : > sequestrants.
    : : > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;
    : : Hook, P.; Holmes-
    : : > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    : : >
    : : > 7. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley,
    : : S. R; Polym.
    : : > Mater. Sci. Eng (1999), 80, 246-247.
    : : >
    : : > 8. Design and characterization of of Sevelamer Hydrochloride: a novel
    : : phosphate-binding
    : : > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.;
    : : Miller, K. L.;
    : : > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and
    : : Appl. Chem.,
    : : > A36(7&8), p. 1085 (1999).
    : : >
    : : > 9. Three generations of bile acid sequestrants. Mandeville, W. H., III;
    : : Braunlin, W.;
    : : > Dhal, P.;
    : : > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;
    : : Rosenbaum, D.;
    : : > Sacchiero,
    : : > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),
    : : 550, 3-15.
    : : >
    : : > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate
    : : binder, on
    : : > urinary
    : : > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;
    : : Mandeville, W. H.,
    : : > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.
    : : (1997), 12(5)
    : : > 961-964.
    : : >
    : : > 11. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley,
    : : S. R.; Yanyo, L.
    : : > C;
    : : > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.
    : : >
    : : > 12. The mechanism of cure initiation of a surface activated adhesive.
    : : Holmes-Farley, S.
    : : > R.;
    : : > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    : : >
    : : > 13. Adhesion promotion and corrosion prevention using thin anisotropic
    : : coatings. Holmes-
    : : > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),
    : : 131-151.
    : : >
    : : > 14. Wetting of functionalized polyethylene having ionizable organic acids
    : : and bases at the
    : : > polymer-water interface: relations between functional group polarity,
    : : extent of
    : : > ionization,
    : : > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;
    : : Whitesides, G. M.;
    : : > Langmuir
    : : > (1988), 4(4), 921-937.
    : : >
    : : > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a
    : : single hydroxy group.
    : : > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    : : >
    : : > 16. Reconstruction of the interface of oxidatively functionalized
    : : polyethylene (PE-CO2H)
    : : > and
    : : > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.;
    : : McCarthy, T. J.;
    : : > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987),
    : : AD-
    : : > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    : : >
    : : > 17. Surface-modified polyethylene film: the relationship between surface
    : : chemistry and
    : : > physical
    : : > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.
    : : >
    : : > 18. Reactivity of carboxylic acid and ester groups in the functionalized
    : : interfacial
    : : > region of
    : : > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:
    : : differentiation of the
    : : > functional groups into shallow and deep subsets based on a comparison of
    : : contact angle and
    : : > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir
    : : (1987), 3(1), 62-
    : : > 76.
    : : >
    : : > 19. Fluorescence properties of dansyl groups covalently bonded tot he
    : : surface of
    : : > oxidatively
    : : > functionalized low-density polyethylene film. Holmes-Farley, S. R.;
    : : Whitesides, G. M.;
    : : > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;
    : : AD-A162435/2/GAR,
    : : > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    : : >
    : : > 20. Acid-base behavior of carboxylic acid groups covalently attached at
    : : the surface of
    : : > polyethylene: The usefulness of contact angle in following the ionization
    : : of surface
    : : > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;
    : : Deutch, J.;
    : : > Whitesides,
    : : > G. M.; Langmuir (1985), 1(6), 725-740.
    : : >
    : : > 21. The thermal stability of a surface modified solid organic polymer.
    : : Holmes-Farley, S.
    : : > R.;
    : : > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    : : >
    : : >
    : : >
    : : > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    : : >
    : : > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced
    : : Aquarist. June 2003.
    : : >
    : : > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.
    : : Advanced Aquarist.
    : : > May
    : : > 2003.
    : : >
    : : > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.
    : : Reefkeeping May
    : : > 2003.
    : : >
    : : > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping
    : : April 2003.
    : : >
    : : > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    : : Holmes-Farley, R.
    : : > Advanced Aquarist; April 2003.
    : : >
    : : > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    : : Holmes-Farley, R.
    : : > Advanced Aquarist; April 2003.
    : : >
    : : > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced Aquarist;
    : : March 2003.
    : : >
    : : > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.
    : : Holmes-Farley, R.
    : : > Advanced Aquarist; February 2003.
    : : >
    : : > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January
    : : 2003.
    : : >
    : : > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; December
    : : 2002.
    : : >
    : : > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R. Advanced
    : : Aquarist; November
    : : > 2002.
    : : >
    : : > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.
    : : Advanced Aquarist;
    : : > November 2002.
    : : >
    : : > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced Aquarist,
    : : September 2002.
    : : >
    : : > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August
    : : 2002.
    : : >
    : : > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April
    : : 2002.
    : : >
    : : > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced
    : : Aquarist; July 2002
    : : >
    : : > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist; June
    : : 2002.
    : : >
    : : > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R. Advanced
    : : Aquarist, May
    : : > 2002.
    : : >
    : : > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.
    : : Holmes-Farley, R.
    : : > Advanced Aquarist, April 2002.
    : : >
    : : > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    : : >
    : : > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    : : >
    : : > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January 2002.
    : : >
    : : > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers
    : : 2000.
    : : >
    : : > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium
    : : Frontiers 2000.
    : : >
    : : > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.
    : : Aquarium Frontiers
    : : > 2000.
    : : > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium Frontiers
    : : 2000.
    : : >
    : : > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers 2000.
    : : >
    : : > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    : : >
    : : > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    : : >
    : : >
    : : >
    : : >
    : : >
    : : >
    : : >
    : : > Boomer
    : : >
    : : > Want to talk chemistry ? The Reef Chemistry Forum
    : : > http://www.reefcentral.com/vbulletin/index.php
    : : >
    : : > Want to See More ?
    : : > Please Join Our Growing Membership
    : : > www.coralrealm.com
    : : >
    : : >
    : : >
    : :
    : :
    :
    :
     
    Boomer, Feb 11, 2004
    #52
  13. Dinky

    stoutman Guest

    Boomer,

    I am not sure if you are just messing with me or if you are truly confused.
    I hope the latter. Please read from Top to Bottom.


    From YOUR first link:

    http://www.waterontheweb.org/resources/glossary.html

    Acidity:
    A measure of how acid a solution may be. A solution with a pH of less than
    7.0 is considered acidic. Solutions with a pH of less than 4.5 contain
    mineral acidity (due to strong inorganic acids), while a solution having a
    pH greater than 8.3 contains no acidity.

    Yes,

    Good definition (for the most part). pH <7 is indeed acidic. pH > 7 is
    basic. Your web page had a definition for acidity, but not basicity.
    Strange. That's like defining GOOD and not defining BAD.

    Here is the IUPAC (International Union of Pure and Applied Chemistry)
    definition of acidity:

    http://www.chem.qmul.ac.uk/iupac/index.html

    acidity

    (1) Of a compound:

    For Brønsted acids it means the tendency of a compound to act as a hydron
    donor. It can be quantitatively expressed by the acid dissociation constant
    of the compound in water or some other specified medium. For Lewis acids it
    relates to the association constants of Lewis adducts and -adducts.

    (2) Of a medium:

    The use of the term is mainly restricted to a medium containing Brønsted
    acids, where it means the tendency of the medium to hydronate a specific
    reference base

    basicity

    For Brønsted bases it means the tendency of a compound to act as hydron
    (proton) acceptor. The basicity of a chemical species is normally expressed
    by the acidity of the conjugate acid (see conjugate acid-base pair). For
    Lewis bases it relates to the association constants of Lewis adducts
    and -adducts



    Another definition from the same web page YOU cited: (this is the same web
    page you cited above)

    Alkalinity:
    Acid neutralizing or buffering capacity of water; a measure of the ability
    of water to resist changes in pH caused by the addition of acids or bases
    and therefore, the main indicator of susceptibility to acid rain; in natural
    waters it is due primarily to the presence of bicarbonates, carbonates and
    to a much lesser extent occasionally borates, silicates and phosphates. It
    is expressed in units of milligrams per liter (mg/l) of CaCO3 (calcium
    carbonate) or as microequivalents per liter (ueq/l) where 20 ueq/l = 1 mg/l
    of CaCO3. A solution having a pH below about 5 contains no alkalinity.

    Your own post defines alkalinity as BUFFERING CAPACITY OF WATER and says
    that alkalinity is the measure of ...(description of a buffer)

    A BUFFER IS : a measure of the ability of water to resist changes in pH
    caused by the addition of acids or bases (from definition below)


    I said:
    ***alkalinity is a measurement of 'buffering capacity'***

    You said:
    ***Alkalinity is not a measurement of BC

    WHY WOULD YOU POST A LINK THAT CONTRADICTS WHAT YOU SAID?? This is not
    logical.

    (THIS FROM THE SAME WEB PAGE YOU CITED):

    Buffer:
    A substance which tends to keep pH levels fairly constant when acids or
    bases are added.

    THIS IS FROM THE DEFINITION OF ALKALINITY FROM SAME WEB PAGE.

    a measure of the ability of water to resist changes in pH caused by the
    addition of acids or bases

    SO DON'T TELL ME THIS SENTENCE DOESN'T DESCRIBE THE ACTIONS OF A BUFFER.


    I went to all four links. None contradict what I have said. But the first
    one you cited contradicts YOU!

    I know what a buffer is. I know what acidity means. I know what alkalinity
    means. No need to cite web pages that describe what I know and what I wrote
    in this discussion. Show me one that says alkalinity is not a measure of
    buffering capacity from a credible source.






    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102kn4e6f2vvb1@corp.supernews.com...
    > Alkalinity a measure of the amount of anions of weak acid in water and of

    the cations
    > balanced against them
    > Take note it says ***acid***
    >
    > Buffering capacity the ability of a solution to resist or dampen changes

    in pH upon the
    > addition of acids or bases.
    > Take note its says ***the addition of acids or bases***
    >
    > One more
    >
    > http://www.waterontheweb.org/resources/glossary.html
    >
    > We could go on like this all day, so what is the point ?
    >
    > You will LOVE this one
    > http://www.kyantec.com/Tips/phbuffering.htm
    >
    > Don't you just lovbe PDF's
    > http://www.inform.umd.edu/manurenet/reprints/98.1702.pdf
    >
    > Don't fall out of your chair
    > http://www.chemforlife.org/teacher/topics/chemistry_in_an_aquarium.htm
    >
    >
    >
    >
    > --
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    > If You See Me Running You Better Catch-Up
    > "stoutman" <.@.> wrote in message news:XB7Wb.19339$QA2.62332@attbi_s52...
    > : Man here is another, google is a wonderful thing. I'm not filtering any
    > : out, just posting what I find by GOOGLING for you.
    > :
    > : http://www.globe.gov/hq/trr_suppl/hydro/HY_SUP_ALK_INTRO_NOTES.HTML
    > :
    > :
    > : Wow, a gov link. Even the government is wrong, this must be a

    conspiracy
    > : against Boomer.
    > :
    > :
    > :
    > :
    > : "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    > : news:102ht0bjplpo059@corp.supernews.com...
    > : > Now I am getting bored
    > : >
    > : > "Don't the components of a buffer account for the buffering capacity?
    > : Yes."
    > : >
    > : > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity

    and
    > : Alkalinity are
    > : > not the same, that has always been the issue. I gave the equation does
    > : that look like an
    > : > Alkalinity equation or how Alk is determined. I see you had now

    comments
    > : on it what's
    > : > wrong, why no comments on the equations I gave. Don't understand them

    or
    > : what ? Again this
    > : > is the equation for Buffering Capacity, also called Buffer Index or

    Buffer
    > : Intensity. It
    > : > is defined in most water chemistry and chemical oceanography text

    books.
    > : >
    > : > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] +

    CKa
    > : [H3O+] / (Ka =
    > : > H3O+])² )
    > : >
    > : > This is not Alkalinity now is it ?
    > : >
    > : > "I know how to do a titration, In fact I have done several. How many

    have
    > : > you actually done? I don't mean by counting drops, I mean with a

    buret?"
    > : >
    > : > Well good for you, I use a Digital Titrator
    > : >
    > : > "Oh, I see,
    > : > you think acidity is the opposite of alkalinity. In the world of
    > : CHEMISTRY
    > : > it's not. Maybe in aquarium newsgroups it is.
    > : >
    > : > Hum no, maybe you should go for a look at HACH's or LaMotte website or

    the
    > : book I
    > : > suggested earlier. Please view a copy.
    > : >
    > : > Standard Methods for the Examination of Water and Wastewater
    > : >
    > : > This book, over 2000 pages, is the guide for water testing. If you are
    > : reporting water
    > : > test to the EPA you must use approved std from this text.I t is

    prepared
    > : and published by
    > : > the EPA, American Water Works Association and American Public Health
    > : Association. You
    > : > mean you don't have one and the issue is water chemistry
    > : >
    > : > You are confusing Acidity and Acidity as you know little about water
    > : chemistry and
    > : > procedures and test methods
    > : >
    > : > From SMEWW, section 2-30, 2310 ACIDITY
    > : >
    > : > "Acidity of water is its quantative capacity to react with a strong

    base
    > : to a designated
    > : > pH"
    > : >
    > : > This is how you test for it
    > : >
    > : > A std alkali titration to methyl orange or phenolphthalein
    > : > endpoint.
    > : >
    > : > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write

    this
    > : book, there are
    > : > over 100 of them, they are wrong.
    > : >
    > : > Like Buffering Capacity you have your Acidity's mixed up
    > : > In water measurement if you have a high Alk you also usually have a

    high
    > : Acidity.
    > : > Normally a high Alk also gives a higher CO2 level. Get a WATER

    CHEMISTRY
    > : BOOK there pal.
    > : >
    > : >
    > : > "These are all in equilibrium with each other. An initial high pH

    (above
    > : > 6.4) will shift the equilibrium to the right to form HCO3-1. If the

    pH of
    > : > the solution is above 10.3 (pKa2) the .........."
    > : >
    > : >
    > : > Christ, there you go again with the FW shit. All your numbers are

    wrong we
    > : are dealing
    > : > with SEAWATER
    > : >
    > : > This means that at a pH of 8.3, the majority of the CO2(aq) is in the

    form
    > : > of HCO3-1 .
    > : >
    > : > I have already pointed that out and gave actual values at know

    seawater
    > : levels, go back
    > : > and re-read it you aren't telling me anything here.Of course most is

    HCO3
    > : see...
    > : >
    > : >
    > : > @ 20C and 34.3 ppt salinity
    > : >
    > : > CO2 = 0.52 %
    > : >
    > : > HCO3 = 86.4 %
    > : >
    > : > CO3 = 13.09 %
    > : >
    > : >
    > : > "In your glass experiment you managed to lower the pH enough to purge

    out
    > : CO2
    > : > by boiling"
    > : >
    > : > The purpose behind the glass is to show that alk is not affect by CO2

    and
    > : vise-versa and
    > : > how Co2 affects pH.
    > : >
    > : > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH

    drops
    > : to say 8.1 it is
    > : > usually due to excess CO2. If you took a glass of that water and

    aerated
    > : it you WILL drive
    > : > off the CO2 and raise the pH. It has been done a proven a million

    times.
    > : >
    > : > "In order to 'purge' CO2 you would need to lower the
    > : > pH to shift the equilibrium to below 6.4"
    > : >
    > : > The hell you do !!!.Do you know who many times people on this NG to
    > : include Dr. Craig
    > : > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a
    > : sample of aquarium
    > : > water and aerate it to see if the pH GOES UP AND when they come back

    with
    > : the test it is
    > : > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST

    excess
    > : CO2 in the tank
    > : > water, increase the circulation for better gas exchange at the

    surface,
    > : reduce feeding,
    > : > and try to improve on better skimming, thus reducing the bio-load and

    pH
    > : decline due to
    > : > CO2.
    > : >
    > : >
    > : > "I hope this helps. "
    > : >
    > : > Help, how can you when you miss everything. I should be charging you
    > : >
    > : > Oh, by the way. Your websites, I have about 50 on these issues, I

    could
    > : post them, not to
    > : > mention I have all those water chemistry books, so there is no need to
    > : view your sites.
    > : >
    > : > Finally are you afraid to come to our Chemistry Forum, afraid to get
    > : slapped by REAL
    > : > chemists. I get a charge out of you can't post your ref .I have posted

    the
    > : same or similar
    > : > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500

    posts
    > : there and am the
    > : > biggest contributor to his forum other than himself or maybe Habib

    Sheka
    > : >
    > : > Hum, here are Randy's ref that he posted. He hosts the website
    > : >
    > : > S. RANDY HOLMES-FARLEY
    > : > Arlington, Massachusetts
    > : >
    > : > EDUCATION
    > : >
    > : > 1982-1986 Harvard University Cambridge, MA
    > : > PhD in Chemistry
    > : > Research Advisor: George Whitesides
    > : >
    > : > Investigated the relationship between polymer surface chemistry and
    > : physical properties
    > : > through controlled surface modification and testing.
    > : >
    > : > 1980-1982 Cornell University Ithaca, NY
    > : > BA in Chemistry and Biology
    > : > Graduated Summa Cum Laude
    > : > Distinction in All Subjects
    > : > Grade Point: 3.94/4.0
    > : > Honors research: isolation and characterization of the subunit of CF1
    > : enzyme
    > : >
    > : >
    > : > 1978-1979 Stanford University Palo Alto, CA
    > : > Grade Point: 3.55/4.0
    > : >
    > : >
    > : > EXPERIENCE
    > : >
    > : > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > : > (bought out GelTex Pharmaceuticals in 2001)
    > : > Vice President, Chemical Research 2001-present
    > : > Senior Director, Chemical Research 1999-2001
    > : > Director of Chemical Research 1997-1999
    > : > Manager of Chemical Research 1995-1997
    > : > Group Leader 1994-1995
    > : > Senior Research Scientist 1992-1994
    > : >
    > : > Helped start GelTex as second employee
    > : >
    > : > Managed various research programs with multi-million dollar budgets
    > : >
    > : > Supervised research chemists (17+)
    > : >
    > : > Co-inventor of several polymeric pharmaceuticals and pharmaceutical
    > : candidates including
    > : > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride

    (FDA
    > : approved)
    > : >
    > : > Company Safety Officer for 3 years
    > : >
    > : > Chemical Hygiene Officer 2000-present
    > : >
    > : >
    > : >
    > : >
    > : > 1990-1992 GTE Corporation Waltham, MA
    > : > Senior Member of Technical Staff
    > : > Applied research involving polymer interfaces
    > : > Metallization of plastics
    > : > Polymer/polymer adhesion
    > : > Optical coatings
    > : >
    > : >
    > : >
    > : > 1986-1990 Lord Corporation Cary, NC
    > : > Senior Research Scientist 1988-1990
    > : > Research Scientist 1986-1988
    > : > Basic and applied research on surface chemical bonding
    > : > Developed new adhesive compositions
    > : > Developed new sol-gel coatings for corrosion resistance
    > : >
    > : >
    > : > HONORS AND AWARDS
    > : >
    > : > Industrial Innovations Award by Northeast Region of American Chemical
    > : Society (6/2001)
    > : >
    > : > National Kidney Foundation of Northern California Honoree (5/2001)
    > : >
    > : > American Chemical Society/Polymer Chemistry Division Industrial

    Sponsors
    > : > Award (8/2000)
    > : >
    > : > R&D 100 Award from R&D magazine (1999)
    > : >
    > : > Sherwin Williams Award in applied polymer science (9/85)
    > : >
    > : > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    > : >
    > : > Award for highest GPA in Chemistry Department (6/82)
    > : >
    > : > Summa Cum Laude Honors in Chemistry (6/82)
    > : >
    > : > Phi Lamda Epsilon (6/82)
    > : >
    > : > Phi Beta Kappa (2/82)
    > : >
    > : > Cornell University Dean's List (1981, 1982)
    > : >
    > : > Harvard Book Club Award for highest GPA senior year (1978)
    > : >
    > : > First Place in western NY ACS high school chemistry exam (1977)
    > : >
    > : > 1978-1979
    > : >
    > : >
    > : > __________________
    > : > Randy Holmes-Farley
    > : > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    > : >
    > : > Hobby Experience: 8 years with reefs
    > : > Current Tanks: 90 gal mixed reef
    > : > Interests: Reefkeeping, science, photography
    > : >
    > : >
    > : > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
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    > : > Open this post in a new window | Report this post to a moderator | IP:
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    > : >
    > : >
    > : > 06/27/2003 02:44 PM
    > : >
    > : > Randy Holmes-Farley
    > : > Chemistry Moderator
    > : >
    > : > Registered: Apr 2001
    > : > Location: Arlington, Massachusetts
    > : > Occupation: Chemist (Drug Discovery at Genzyme)
    > : > Posts: 15282
    > : >
    > : >
    > : >
    > : > Publications
    > : >
    > : >
    > : > ISSUED UNITED STATES PATENTS
    > : >
    > : >
    > : > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;
    > : Mandeville, III; W. Harry.
    > : > US 6,566,407; 5/20/2003
    > : >
    > : > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen

    Randall;
    > : Huval, Chad
    > : > Cori.
    > : > U.S. 6,517,825; 2/11/2003.
    > : >
    > : > 3. Method of making phosphate-binding polymers for oral

    administration.
    > : Holmes-Farley,
    > : > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.
    > : 6,509,013; 1/21/2003.
    > : >
    > : > 4. Combination therapy for treating hypercholesterolemia using a bile

    acid
    > : sequestrant
    > : > polymer
    > : > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley,

    Stephen
    > : Randall;
    > : > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    > : >
    > : > 5. Method for treating hypercholesterolemia with polyallylamine

    polymers.
    > : Holmes-Farley,
    > : > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.;

    Goldberg,
    > : Dennis I. , US
    > : > 6,423,754; 7/23/2002.
    > : >
    > : > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;
    > : Neenan, Thomas X..;
    > : > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    > : >
    > : > 7. Combination therapy for treating hypercholesterolemia and
    > : atherosclerosis. Huval, Chad
    > : > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep

    K.
    > : U.S. 6,365,186;
    > : > 4/2/2002.
    > : >
    > : > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.;

    Mandeville,
    > : W. H., III;
    > : > Huval; C.
    > : > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;
    > : 10/9/2001.
    > : >
    > : > 9. Polymers containing guanidinium groups as bile acid sequestrants.

    Dhal;
    > : P. K.; Holmes-
    > : > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    > : >
    > : > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 6,281,252;
    > : > 8/28/2001.
    > : >
    > : > 11. Combination therapy for treating hypercholestrolemia. Huval; C.

    C.;
    > : Holmes-Farley; S.
    > : > R. ;
    > : > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    > : >
    > : > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;
    > : Holmes-Farley, S.
    > : > R.; US
    > : > 6,264,937; 7/24/2001.
    > : >
    > : > 13. Method for treating hypercholesterolemia with unsubstituted
    > : polydiallylamine polymers.
    > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    > : 6,248,318;
    > : > 6/19/2001.
    > : >
    > : > 14. Process for removing bile salts from a patient and alkylated
    > : compositions therefore.
    > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    > : >
    > : > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S.

    R.;
    > : Dhal, P. K.;
    > : > Petersen,
    > : > J. S.; US 6,203,785; 3/20/2001.
    > : >
    > : > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.;

    Huval,
    > : C. C.; US
    > : > 6,190,649;
    > : > 2/20/2001.
    > : >
    > : > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 6,177,478;
    > : > 1/23/2001.
    > : >
    > : > 18. Water-insoluble noncrosslinked bile acid sequestrants.

    Holmes-Farley,
    > : S. R.;
    > : > Mandeville, W.
    > : > H., III.; US 6,129,910; 10/10/2000.
    > : >
    > : > 19. Method for treating hypercholesterolemia with unsubstituted
    > : polydiallylamine polymers.
    > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    > : 6,083,497;
    > : > 7/4/2000.
    > : >
    > : > 20. Method of making phosphate-binding polymers for oral

    administration.
    > : Holmes-Farley, S.
    > : > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495;

    7/4/2000.
    > : >
    > : > 21. Process for removing bile salts from a patient and alkylated
    > : compositions therefore.
    > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678;

    5/23/2000.
    > : >
    > : > 22. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    > : >
    > : > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;
    > : Neenan; T. X.; Holmes-
    > : > Farley; S. R. US 6,034,129; 3/7/2000.
    > : >
    > : > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 5,985,938;
    > : > 11/16/99.
    > : >
    > : > 25. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    > : >
    > : > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W.

    H.,
    > : III.;
    > : > Holmes-Farley;
    > : > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    > : >
    > : > 27. Hydrophilic nonamine-containing and amine-containing copolymers

    and
    > : their use as bile
    > : > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US

    5,929,184;
    > : 7/27/99.
    > : >
    > : > 28. Interpenetrating polymer networks for sequestration of bile acids.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;
    > : 7/20/99.
    > : >
    > : > 29. Amine polymer sequestrant and method of cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    > : >
    > : > 30. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    > : >
    > : > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    > : >
    > : > 32. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    > : >
    > : > 33. Preparation of polymeric sequestrants for bile acid salts.

    Mandeville,
    > : W. H., III.;
    > : > Holmes-
    > : > Farley, S. R.; US 5,703,188; 12/30/97.
    > : >
    > : > 34. Oral administration of iron-binding crosslinked amine polymers.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    > : >
    > : > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley,

    S.
    > : R.; US 5,693,675;
    > : > 12/2/97.
    > : >
    > : > 36. Method for removing bile salts from a patient with alkylated
    > : crosslinked amine
    > : > polymers,
    > : > and preparation of the polymers. Mandeville, W. H., III.;

    Holmes-Farley,
    > : S. R.; US
    > : > 5,679,717; 10/21/97.
    > : >
    > : > 37. Phosphate-binding polymers for oral administration. Holmes-Farley,

    S.
    > : R.; Mandeville,
    > : > W.
    > : > H., III.; US 5,667,775; 9/16/97.
    > : >
    > : > 38. Ion-exchange process using highly crosslinked polymers for

    removing
    > : bile salts from a
    > : > patient, preparation of the polymers, and compositions containing

    them.
    > : Mandeville, W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    > : >
    > : > 39. Hydrophobic amine polymer sequestrant and method of cholesterol
    > : depletion. Mandeville,
    > : > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530;

    4/8/97.
    > : >
    > : > 40. Amine polymer sequestrant and method of cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    > : >
    > : > 41. Phosphate-binding polymers for oral administration. Holmes-Farley,

    S.
    > : R.; Mandeville,
    > : > W.
    > : > H., III.; US 5,496,545; 3/5/96.
    > : >
    > : > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,
    > : III.; Holmes-Farley,
    > : > S. R.;
    > : > US 5,487,888; 1/30/96.
    > : >
    > : > 43. Ultra-thin, uniform sol-gel coating of a substrate having active
    > : hydrogens on the
    > : > surface.
    > : > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    > : >
    > : > 44. Layered sol-gel coatings from organisilicon compounds.

    Holmes-Farley,
    > : S. R.; Yanyo, L.
    > : > C.;
    > : > US 5,182,143; 1/26/93.
    > : >
    > : > 45. Method for metal bonding using ultrathin primer coating.
    > : Holmes-Farley, S. R.; Yanyo,
    > : > L.
    > : > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    > : >
    > : > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.;

    US
    > : 5,096,962;
    > : > 3/17/92.
    > : >
    > : > 47. Modified halogenatedpolyolefin adhesives for polyolefin
    > : elastomer-metal bonding.
    > : > Holmes-
    > : > Farley, S. R.; US 5,102,956; 4/7/92.
    > : >
    > : >
    > : >
    > : > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    > : >
    > : >
    > : > 1. Aryl boronate functionalized polymers for treating obesity and
    > : inhibiting fat uptake.
    > : > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal,

    Pradeep
    > : K.; Huval, Chad
    > : > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92

    pp. WO
    > : 0302571.
    > : >
    > : > 2. Preparation of aryl boronic acids for treating obesity.

    Holmes-Farley,
    > : Stephen Randall;
    > : > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep

    K.
    > : (Geltex
    > : > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    > : >
    > : > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,
    > : Stephen Randall.
    > : > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO
    > : 0302130.
    > : >
    > : > 4. Method for reducing copper levels and treating copper toxicosis.
    > : Holmes-Farley, Stephen
    > : > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002),

    45
    > : pp. WO
    > : > 0285383.
    > : >
    > : > 5. Method for treating gout and binding uric acid. Holmes-Farley,

    Stephen
    > : Randall; Burke,
    > : > Steven K. WO 0285381 10/31/2002.
    > : >
    > : > 6. Method for treating gout and reducing serum uric acid.

    Holmes-Farley,
    > : Stephen Randall;
    > : > Burke, Steven K WO 0285380 10/31/2002.
    > : >
    > : > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;
    > : Holmes-Farley, S. R.;
    > : > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    > : >
    > : > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and
    > : Holmes-Farley, S.
    > : > R.;
    > : > WO 1999-US5662; 9/23/1999.
    > : >
    > : > 9. Amine-containing copolymers as bile acid sequestrants.

    Holmes-Farley,
    > : S. R.; Petersen,
    > : > J. S.;
    > : > WO 9933452; 7/8/1999.
    > : >
    > : > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III

    and
    > : Holmes-Farley, S.
    > : > R.;
    > : > WO 9922743; 5/14/1999.
    > : >
    > : > 11. Polyallylamine polymers for removing bile salts and treating
    > : hypercholesterolemia, and
    > : > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III;

    Burke,
    > : S. K.; Goldberg,
    > : > D. I.; WO 9857652; 12/23/98.
    > : >
    > : > 12. Phosphate-bidning polymers combined with a calcium supplement for

    oral
    > : administration.
    > : > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley,

    S.
    > : R.; WO 9842355;
    > : > 10/1/98.
    > : >
    > : > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol
    > : depletion. Mandeville,
    > : > W.
    > : > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    > : >
    > : > 14. Process for adjusting ion concentration in a patient and

    compositions
    > : therefor.
    > : > Mandeville,
    > : > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    > : >
    > : > 15. Vacuum-deposited silver on polycarbonate with a chromium

    interlayer
    > : for improved
    > : > metal-
    > : > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512;

    1/20/94.
    > : >
    > : > 16. Process for increased metal-substrate bond strength in metalized
    > : plastics.
    > : > Holmes-Farley, S.
    > : > R.; Ger. Offen. 4322516; 7/6/93.
    > : >
    > : > 17. Electrorheological fluids and preparation of particles useful in

    the
    > : fluids.
    > : > Troughton,
    > : > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.
    > : David; Bares, Joseph
    > : > E.;
    > : > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP
    > : 394049;
    > : > 10/24/1990.
    > : >
    > : > JOURNAL PUBLICATIONS
    > : >
    > : > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov,

    Eugene;
    > : Guo, Amy;
    > : > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;
    > : Mandeville, W. Harry;
    > : > Holmes-Farley, S. Randall. Kidney International (2002), 62(2),

    611-619.
    > : >
    > : > 2. Amine functionalized polyethers as bile acid sequestrants:

    synthesis
    > : and biological
    > : > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S.

    Randall;
    > : Mandeville, W.
    > : > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.
    > : Journal of
    > : > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),
    > : 1559-1574.
    > : >
    > : > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular
    > : Imprinting. Huval,
    > : > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.
    > : Randall; Mandeville,
    > : > W.
    > : > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert

    J.;
    > : Chen, Xi; Dhal,
    > : > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    > : >
    > : > 4. Synthetic polymers for the binding of fat in the intestinal tract.
    > : Jozefiak, Thomas H.;
    > : > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia;

    Huval,
    > : Chad C.;
    > : > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.
    > : Abstracts of
    > : > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August
    > : 26-30, 2001
    > : > (2001), POLY-047 and Polymer Preprints (American Chemical Society,
    > : Division of
    > : > Polymer Chemistry) (2001), 42(2), 98.
    > : >
    > : > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer

    gel
    > : pharmaceutical.
    > : > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.;

    Ward,
    > : J.; Sacchiero,
    > : > B.;
    > : > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.;

    Chen,
    > : X.; Mazzeo, J.
    > : > R.. Polym. Preprints (2000), 41(1), 735-736.
    > : >
    > : > 6. In vitro comparison of bile acid binding to colesevelam HCl and

    other
    > : bile acid
    > : > sequestrants.
    > : > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;
    > : Hook, P.; Holmes-
    > : > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    > : >
    > : > 7. Novel polymeric pharmaceuticals: From startup to market.

    Holmes-Farley,
    > : S. R; Polym.
    > : > Mater. Sci. Eng (1999), 80, 246-247.
    > : >
    > : > 8. Design and characterization of of Sevelamer Hydrochloride: a novel
    > : phosphate-binding
    > : > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward,

    J.;
    > : Miller, K. L.;
    > : > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure

    and
    > : Appl. Chem.,
    > : > A36(7&8), p. 1085 (1999).
    > : >
    > : > 9. Three generations of bile acid sequestrants. Mandeville, W. H.,

    III;
    > : Braunlin, W.;
    > : > Dhal, P.;
    > : > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;
    > : Rosenbaum, D.;
    > : > Sacchiero,
    > : > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),
    > : 550, 3-15.
    > : >
    > : > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric

    phosphate
    > : binder, on
    > : > urinary
    > : > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;
    > : Mandeville, W. H.,
    > : > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.
    > : (1997), 12(5)
    > : > 961-964.
    > : >
    > : > 11. Thin anisotropic coatings based on sol-gel technology.

    Holmes-Farley,
    > : S. R.; Yanyo, L.
    > : > C;
    > : > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4),

    439-444.
    > : >
    > : > 12. The mechanism of cure initiation of a surface activated adhesive.
    > : Holmes-Farley, S.
    > : > R.;
    > : > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    > : >
    > : > 13. Adhesion promotion and corrosion prevention using thin anisotropic
    > : coatings. Holmes-
    > : > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),
    > : 131-151.
    > : >
    > : > 14. Wetting of functionalized polyethylene having ionizable organic

    acids
    > : and bases at the
    > : > polymer-water interface: relations between functional group polarity,
    > : extent of
    > : > ionization,
    > : > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;
    > : Whitesides, G. M.;
    > : > Langmuir
    > : > (1988), 4(4), 921-937.
    > : >
    > : > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a
    > : single hydroxy group.
    > : > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    > : >
    > : > 16. Reconstruction of the interface of oxidatively functionalized
    > : polyethylene (PE-CO2H)
    > : > and
    > : > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo,

    R.;
    > : McCarthy, T. J.;
    > : > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report

    (1987),
    > : AD-
    > : > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    > : >
    > : > 17. Surface-modified polyethylene film: the relationship between

    surface
    > : chemistry and
    > : > physical
    > : > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11),

    4537.
    > : >
    > : > 18. Reactivity of carboxylic acid and ester groups in the

    functionalized
    > : interfacial
    > : > region of
    > : > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:
    > : differentiation of the
    > : > functional groups into shallow and deep subsets based on a comparison

    of
    > : contact angle and
    > : > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir
    > : (1987), 3(1), 62-
    > : > 76.
    > : >
    > : > 19. Fluorescence properties of dansyl groups covalently bonded tot he
    > : surface of
    > : > oxidatively
    > : > functionalized low-density polyethylene film. Holmes-Farley, S. R.;
    > : Whitesides, G. M.;
    > : > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;
    > : AD-A162435/2/GAR,
    > : > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    > : >
    > : > 20. Acid-base behavior of carboxylic acid groups covalently attached

    at
    > : the surface of
    > : > polyethylene: The usefulness of contact angle in following the

    ionization
    > : of surface
    > : > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;
    > : Deutch, J.;
    > : > Whitesides,
    > : > G. M.; Langmuir (1985), 1(6), 725-740.
    > : >
    > : > 21. The thermal stability of a surface modified solid organic polymer.
    > : Holmes-Farley, S.
    > : > R.;
    > : > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    > : >
    > : >
    > : >
    > : > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    > : >
    > : > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced
    > : Aquarist. June 2003.
    > : >
    > : > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.
    > : Advanced Aquarist.
    > : > May
    > : > 2003.
    > : >
    > : > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.
    > : Reefkeeping May
    > : > 2003.
    > : >
    > : > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping
    > : April 2003.
    > : >
    > : > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; April 2003.
    > : >
    > : > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; April 2003.
    > : >
    > : > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced

    Aquarist;
    > : March 2003.
    > : >
    > : > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; February 2003.
    > : >
    > : > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January
    > : 2003.
    > : >
    > : > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist;

    December
    > : 2002.
    > : >
    > : > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R.

    Advanced
    > : Aquarist; November
    > : > 2002.
    > : >
    > : > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.
    > : Advanced Aquarist;
    > : > November 2002.
    > : >
    > : > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced

    Aquarist,
    > : September 2002.
    > : >
    > : > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August
    > : 2002.
    > : >
    > : > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April
    > : 2002.
    > : >
    > : > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced
    > : Aquarist; July 2002
    > : >
    > : > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist;

    June
    > : 2002.
    > : >
    > : > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R.

    Advanced
    > : Aquarist, May
    > : > 2002.
    > : >
    > : > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist, April 2002.
    > : >
    > : > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    > : >
    > : > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    > : >
    > : > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January

    2002.
    > : >
    > : > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers
    > : 2000.
    > : >
    > : > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium
    > : Frontiers 2000.
    > : >
    > : > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.
    > : Aquarium Frontiers
    > : > 2000.
    > : > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium

    Frontiers
    > : 2000.
    > : >
    > : > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers

    2000.
    > : >
    > : > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    > : >
    > : > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    > : >
    > : >
    > : >
    > : >
    > : >
    > : >
    > : >
    > : > Boomer
    > : >
    > : > Want to talk chemistry ? The Reef Chemistry Forum
    > : > http://www.reefcentral.com/vbulletin/index.php
    > : >
    > : > Want to See More ?
    > : > Please Join Our Growing Membership
    > : > www.coralrealm.com
    > : >
    > : >
    > : >
    > :
    > :
    >
    >
     
    stoutman, Feb 11, 2004
    #53
  14. Dinky

    stoutman Guest

    Boomer,

    I am not sure if you are just messing with me or if you are truly confused.
    I hope the latter. Please read from Top to Bottom.


    From YOUR first link:

    http://www.waterontheweb.org/resources/glossary.html

    Acidity:
    A measure of how acid a solution may be. A solution with a pH of less than
    7.0 is considered acidic. Solutions with a pH of less than 4.5 contain
    mineral acidity (due to strong inorganic acids), while a solution having a
    pH greater than 8.3 contains no acidity.

    Yes,

    Good definition (for the most part). pH <7 is indeed acidic. pH > 7 is
    basic. Your web page had a definition for acidity, but not basicity.
    Strange. That's like defining GOOD and not defining BAD.

    Here is the IUPAC (International Union of Pure and Applied Chemistry)
    definition of acidity:

    http://www.chem.qmul.ac.uk/iupac/index.html

    acidity

    (1) Of a compound:

    For Brønsted acids it means the tendency of a compound to act as a hydron
    donor. It can be quantitatively expressed by the acid dissociation constant
    of the compound in water or some other specified medium. For Lewis acids it
    relates to the association constants of Lewis adducts and -adducts.

    (2) Of a medium:

    The use of the term is mainly restricted to a medium containing Brønsted
    acids, where it means the tendency of the medium to hydronate a specific
    reference base

    basicity

    For Brønsted bases it means the tendency of a compound to act as hydron
    (proton) acceptor. The basicity of a chemical species is normally expressed
    by the acidity of the conjugate acid (see conjugate acid-base pair). For
    Lewis bases it relates to the association constants of Lewis adducts
    and -adducts



    Another definition from the same web page YOU cited: (this is the same web
    page you cited above)

    Alkalinity:
    Acid neutralizing or buffering capacity of water; a measure of the ability
    of water to resist changes in pH caused by the addition of acids or bases
    and therefore, the main indicator of susceptibility to acid rain; in natural
    waters it is due primarily to the presence of bicarbonates, carbonates and
    to a much lesser extent occasionally borates, silicates and phosphates. It
    is expressed in units of milligrams per liter (mg/l) of CaCO3 (calcium
    carbonate) or as microequivalents per liter (ueq/l) where 20 ueq/l = 1 mg/l
    of CaCO3. A solution having a pH below about 5 contains no alkalinity.

    Your own post defines alkalinity as BUFFERING CAPACITY OF WATER and says
    that alkalinity is the measure of ...(the properties of a buffer)


    I said:
    ***alkalinity is a measurement of 'buffering capacity'***

    You said:
    ***Alkalinity is not a measurement of BC

    WHY WOULD YOU POST A LINK THAT CONTRADICTS WHAT YOU SAID?? This is not
    logical.

    (THIS FROM THE SAME WEB PAGE YOU CITED):

    Buffer:
    A substance which tends to keep pH levels fairly constant when acids or
    bases are added.

    THIS IS FROM THE DEFINITION OF ALKALINITY FROM SAME WEB PAGE.

    a measure of the ability of water to resist changes in pH caused by the
    addition of acids or bases

    SO DON'T TELL ME THIS SENTENCE DOESN'T DESCRIBE THE ACTIONS OF A BUFFER.


    I went to all four links. None contradict what I have said. But the first
    one you cited contradicts YOU!

    I know what a buffer is. I know what acidity means. I know what alkalinity
    means. No need to cite web pages that describe what I know and what I wrote
    in this discussion. Show me one that says alkalinity is not a measure of
    buffering capacity from a credible source.




    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102kn4e6f2vvb1@corp.supernews.com...
    > Alkalinity a measure of the amount of anions of weak acid in water and of

    the cations
    > balanced against them
    > Take note it says ***acid***
    >
    > Buffering capacity the ability of a solution to resist or dampen changes

    in pH upon the
    > addition of acids or bases.
    > Take note its says ***the addition of acids or bases***
    >
    > One more
    >
    > http://www.waterontheweb.org/resources/glossary.html
    >
    > We could go on like this all day, so what is the point ?
    >
    > You will LOVE this one
    > http://www.kyantec.com/Tips/phbuffering.htm
    >
    > Don't you just lovbe PDF's
    > http://www.inform.umd.edu/manurenet/reprints/98.1702.pdf
    >
    > Don't fall out of your chair
    > http://www.chemforlife.org/teacher/topics/chemistry_in_an_aquarium.htm
    >
    >
    >
    >
    > --
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    > If You See Me Running You Better Catch-Up
    > "stoutman" <.@.> wrote in message news:XB7Wb.19339$QA2.62332@attbi_s52...
    > : Man here is another, google is a wonderful thing. I'm not filtering any
    > : out, just posting what I find by GOOGLING for you.
    > :
    > : http://www.globe.gov/hq/trr_suppl/hydro/HY_SUP_ALK_INTRO_NOTES.HTML
    > :
    > :
    > : Wow, a gov link. Even the government is wrong, this must be a

    conspiracy
    > : against Boomer.
    > :
    > :
    > :
    > :
    > : "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    > : news:102ht0bjplpo059@corp.supernews.com...
    > : > Now I am getting bored
    > : >
    > : > "Don't the components of a buffer account for the buffering capacity?
    > : Yes."
    > : >
    > : > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity

    and
    > : Alkalinity are
    > : > not the same, that has always been the issue. I gave the equation does
    > : that look like an
    > : > Alkalinity equation or how Alk is determined. I see you had now

    comments
    > : on it what's
    > : > wrong, why no comments on the equations I gave. Don't understand them

    or
    > : what ? Again this
    > : > is the equation for Buffering Capacity, also called Buffer Index or

    Buffer
    > : Intensity. It
    > : > is defined in most water chemistry and chemical oceanography text

    books.
    > : >
    > : > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] +

    CKa
    > : [H3O+] / (Ka =
    > : > H3O+])² )
    > : >
    > : > This is not Alkalinity now is it ?
    > : >
    > : > "I know how to do a titration, In fact I have done several. How many

    have
    > : > you actually done? I don't mean by counting drops, I mean with a

    buret?"
    > : >
    > : > Well good for you, I use a Digital Titrator
    > : >
    > : > "Oh, I see,
    > : > you think acidity is the opposite of alkalinity. In the world of
    > : CHEMISTRY
    > : > it's not. Maybe in aquarium newsgroups it is.
    > : >
    > : > Hum no, maybe you should go for a look at HACH's or LaMotte website or

    the
    > : book I
    > : > suggested earlier. Please view a copy.
    > : >
    > : > Standard Methods for the Examination of Water and Wastewater
    > : >
    > : > This book, over 2000 pages, is the guide for water testing. If you are
    > : reporting water
    > : > test to the EPA you must use approved std from this text.I t is

    prepared
    > : and published by
    > : > the EPA, American Water Works Association and American Public Health
    > : Association. You
    > : > mean you don't have one and the issue is water chemistry
    > : >
    > : > You are confusing Acidity and Acidity as you know little about water
    > : chemistry and
    > : > procedures and test methods
    > : >
    > : > From SMEWW, section 2-30, 2310 ACIDITY
    > : >
    > : > "Acidity of water is its quantative capacity to react with a strong

    base
    > : to a designated
    > : > pH"
    > : >
    > : > This is how you test for it
    > : >
    > : > A std alkali titration to methyl orange or phenolphthalein
    > : > endpoint.
    > : >
    > : > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write

    this
    > : book, there are
    > : > over 100 of them, they are wrong.
    > : >
    > : > Like Buffering Capacity you have your Acidity's mixed up
    > : > In water measurement if you have a high Alk you also usually have a

    high
    > : Acidity.
    > : > Normally a high Alk also gives a higher CO2 level. Get a WATER

    CHEMISTRY
    > : BOOK there pal.
    > : >
    > : >
    > : > "These are all in equilibrium with each other. An initial high pH

    (above
    > : > 6.4) will shift the equilibrium to the right to form HCO3-1. If the

    pH of
    > : > the solution is above 10.3 (pKa2) the .........."
    > : >
    > : >
    > : > Christ, there you go again with the FW shit. All your numbers are

    wrong we
    > : are dealing
    > : > with SEAWATER
    > : >
    > : > This means that at a pH of 8.3, the majority of the CO2(aq) is in the

    form
    > : > of HCO3-1 .
    > : >
    > : > I have already pointed that out and gave actual values at know

    seawater
    > : levels, go back
    > : > and re-read it you aren't telling me anything here.Of course most is

    HCO3
    > : see...
    > : >
    > : >
    > : > @ 20C and 34.3 ppt salinity
    > : >
    > : > CO2 = 0.52 %
    > : >
    > : > HCO3 = 86.4 %
    > : >
    > : > CO3 = 13.09 %
    > : >
    > : >
    > : > "In your glass experiment you managed to lower the pH enough to purge

    out
    > : CO2
    > : > by boiling"
    > : >
    > : > The purpose behind the glass is to show that alk is not affect by CO2

    and
    > : vise-versa and
    > : > how Co2 affects pH.
    > : >
    > : > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH

    drops
    > : to say 8.1 it is
    > : > usually due to excess CO2. If you took a glass of that water and

    aerated
    > : it you WILL drive
    > : > off the CO2 and raise the pH. It has been done a proven a million

    times.
    > : >
    > : > "In order to 'purge' CO2 you would need to lower the
    > : > pH to shift the equilibrium to below 6.4"
    > : >
    > : > The hell you do !!!.Do you know who many times people on this NG to
    > : include Dr. Craig
    > : > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a
    > : sample of aquarium
    > : > water and aerate it to see if the pH GOES UP AND when they come back

    with
    > : the test it is
    > : > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST

    excess
    > : CO2 in the tank
    > : > water, increase the circulation for better gas exchange at the

    surface,
    > : reduce feeding,
    > : > and try to improve on better skimming, thus reducing the bio-load and

    pH
    > : decline due to
    > : > CO2.
    > : >
    > : >
    > : > "I hope this helps. "
    > : >
    > : > Help, how can you when you miss everything. I should be charging you
    > : >
    > : > Oh, by the way. Your websites, I have about 50 on these issues, I

    could
    > : post them, not to
    > : > mention I have all those water chemistry books, so there is no need to
    > : view your sites.
    > : >
    > : > Finally are you afraid to come to our Chemistry Forum, afraid to get
    > : slapped by REAL
    > : > chemists. I get a charge out of you can't post your ref .I have posted

    the
    > : same or similar
    > : > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500

    posts
    > : there and am the
    > : > biggest contributor to his forum other than himself or maybe Habib

    Sheka
    > : >
    > : > Hum, here are Randy's ref that he posted. He hosts the website
    > : >
    > : > S. RANDY HOLMES-FARLEY
    > : > Arlington, Massachusetts
    > : >
    > : > EDUCATION
    > : >
    > : > 1982-1986 Harvard University Cambridge, MA
    > : > PhD in Chemistry
    > : > Research Advisor: George Whitesides
    > : >
    > : > Investigated the relationship between polymer surface chemistry and
    > : physical properties
    > : > through controlled surface modification and testing.
    > : >
    > : > 1980-1982 Cornell University Ithaca, NY
    > : > BA in Chemistry and Biology
    > : > Graduated Summa Cum Laude
    > : > Distinction in All Subjects
    > : > Grade Point: 3.94/4.0
    > : > Honors research: isolation and characterization of the subunit of CF1
    > : enzyme
    > : >
    > : >
    > : > 1978-1979 Stanford University Palo Alto, CA
    > : > Grade Point: 3.55/4.0
    > : >
    > : >
    > : > EXPERIENCE
    > : >
    > : > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > : > (bought out GelTex Pharmaceuticals in 2001)
    > : > Vice President, Chemical Research 2001-present
    > : > Senior Director, Chemical Research 1999-2001
    > : > Director of Chemical Research 1997-1999
    > : > Manager of Chemical Research 1995-1997
    > : > Group Leader 1994-1995
    > : > Senior Research Scientist 1992-1994
    > : >
    > : > Helped start GelTex as second employee
    > : >
    > : > Managed various research programs with multi-million dollar budgets
    > : >
    > : > Supervised research chemists (17+)
    > : >
    > : > Co-inventor of several polymeric pharmaceuticals and pharmaceutical
    > : candidates including
    > : > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride

    (FDA
    > : approved)
    > : >
    > : > Company Safety Officer for 3 years
    > : >
    > : > Chemical Hygiene Officer 2000-present
    > : >
    > : >
    > : >
    > : >
    > : > 1990-1992 GTE Corporation Waltham, MA
    > : > Senior Member of Technical Staff
    > : > Applied research involving polymer interfaces
    > : > Metallization of plastics
    > : > Polymer/polymer adhesion
    > : > Optical coatings
    > : >
    > : >
    > : >
    > : > 1986-1990 Lord Corporation Cary, NC
    > : > Senior Research Scientist 1988-1990
    > : > Research Scientist 1986-1988
    > : > Basic and applied research on surface chemical bonding
    > : > Developed new adhesive compositions
    > : > Developed new sol-gel coatings for corrosion resistance
    > : >
    > : >
    > : > HONORS AND AWARDS
    > : >
    > : > Industrial Innovations Award by Northeast Region of American Chemical
    > : Society (6/2001)
    > : >
    > : > National Kidney Foundation of Northern California Honoree (5/2001)
    > : >
    > : > American Chemical Society/Polymer Chemistry Division Industrial

    Sponsors
    > : > Award (8/2000)
    > : >
    > : > R&D 100 Award from R&D magazine (1999)
    > : >
    > : > Sherwin Williams Award in applied polymer science (9/85)
    > : >
    > : > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    > : >
    > : > Award for highest GPA in Chemistry Department (6/82)
    > : >
    > : > Summa Cum Laude Honors in Chemistry (6/82)
    > : >
    > : > Phi Lamda Epsilon (6/82)
    > : >
    > : > Phi Beta Kappa (2/82)
    > : >
    > : > Cornell University Dean's List (1981, 1982)
    > : >
    > : > Harvard Book Club Award for highest GPA senior year (1978)
    > : >
    > : > First Place in western NY ACS high school chemistry exam (1977)
    > : >
    > : > 1978-1979
    > : >
    > : >
    > : > __________________
    > : > Randy Holmes-Farley
    > : > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    > : >
    > : > Hobby Experience: 8 years with reefs
    > : > Current Tanks: 90 gal mixed reef
    > : > Interests: Reefkeeping, science, photography
    > : >
    > : >
    > : > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    > : >
    > : > Open this post in a new window | Report this post to a moderator | IP:
    > : Logged
    > : >
    > : >
    > : >
    > : > 06/27/2003 02:44 PM
    > : >
    > : > Randy Holmes-Farley
    > : > Chemistry Moderator
    > : >
    > : > Registered: Apr 2001
    > : > Location: Arlington, Massachusetts
    > : > Occupation: Chemist (Drug Discovery at Genzyme)
    > : > Posts: 15282
    > : >
    > : >
    > : >
    > : > Publications
    > : >
    > : >
    > : > ISSUED UNITED STATES PATENTS
    > : >
    > : >
    > : > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;
    > : Mandeville, III; W. Harry.
    > : > US 6,566,407; 5/20/2003
    > : >
    > : > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen

    Randall;
    > : Huval, Chad
    > : > Cori.
    > : > U.S. 6,517,825; 2/11/2003.
    > : >
    > : > 3. Method of making phosphate-binding polymers for oral

    administration.
    > : Holmes-Farley,
    > : > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.
    > : 6,509,013; 1/21/2003.
    > : >
    > : > 4. Combination therapy for treating hypercholesterolemia using a bile

    acid
    > : sequestrant
    > : > polymer
    > : > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley,

    Stephen
    > : Randall;
    > : > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    > : >
    > : > 5. Method for treating hypercholesterolemia with polyallylamine

    polymers.
    > : Holmes-Farley,
    > : > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.;

    Goldberg,
    > : Dennis I. , US
    > : > 6,423,754; 7/23/2002.
    > : >
    > : > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;
    > : Neenan, Thomas X..;
    > : > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    > : >
    > : > 7. Combination therapy for treating hypercholesterolemia and
    > : atherosclerosis. Huval, Chad
    > : > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep

    K.
    > : U.S. 6,365,186;
    > : > 4/2/2002.
    > : >
    > : > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.;

    Mandeville,
    > : W. H., III;
    > : > Huval; C.
    > : > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;
    > : 10/9/2001.
    > : >
    > : > 9. Polymers containing guanidinium groups as bile acid sequestrants.

    Dhal;
    > : P. K.; Holmes-
    > : > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    > : >
    > : > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 6,281,252;
    > : > 8/28/2001.
    > : >
    > : > 11. Combination therapy for treating hypercholestrolemia. Huval; C.

    C.;
    > : Holmes-Farley; S.
    > : > R. ;
    > : > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    > : >
    > : > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;
    > : Holmes-Farley, S.
    > : > R.; US
    > : > 6,264,937; 7/24/2001.
    > : >
    > : > 13. Method for treating hypercholesterolemia with unsubstituted
    > : polydiallylamine polymers.
    > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    > : 6,248,318;
    > : > 6/19/2001.
    > : >
    > : > 14. Process for removing bile salts from a patient and alkylated
    > : compositions therefore.
    > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    > : >
    > : > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S.

    R.;
    > : Dhal, P. K.;
    > : > Petersen,
    > : > J. S.; US 6,203,785; 3/20/2001.
    > : >
    > : > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.;

    Huval,
    > : C. C.; US
    > : > 6,190,649;
    > : > 2/20/2001.
    > : >
    > : > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 6,177,478;
    > : > 1/23/2001.
    > : >
    > : > 18. Water-insoluble noncrosslinked bile acid sequestrants.

    Holmes-Farley,
    > : S. R.;
    > : > Mandeville, W.
    > : > H., III.; US 6,129,910; 10/10/2000.
    > : >
    > : > 19. Method for treating hypercholesterolemia with unsubstituted
    > : polydiallylamine polymers.
    > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    > : 6,083,497;
    > : > 7/4/2000.
    > : >
    > : > 20. Method of making phosphate-binding polymers for oral

    administration.
    > : Holmes-Farley, S.
    > : > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495;

    7/4/2000.
    > : >
    > : > 21. Process for removing bile salts from a patient and alkylated
    > : compositions therefore.
    > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678;

    5/23/2000.
    > : >
    > : > 22. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    > : >
    > : > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;
    > : Neenan; T. X.; Holmes-
    > : > Farley; S. R. US 6,034,129; 3/7/2000.
    > : >
    > : > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 5,985,938;
    > : > 11/16/99.
    > : >
    > : > 25. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    > : >
    > : > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W.

    H.,
    > : III.;
    > : > Holmes-Farley;
    > : > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    > : >
    > : > 27. Hydrophilic nonamine-containing and amine-containing copolymers

    and
    > : their use as bile
    > : > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US

    5,929,184;
    > : 7/27/99.
    > : >
    > : > 28. Interpenetrating polymer networks for sequestration of bile acids.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;
    > : 7/20/99.
    > : >
    > : > 29. Amine polymer sequestrant and method of cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    > : >
    > : > 30. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    > : >
    > : > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    > : >
    > : > 32. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    > : >
    > : > 33. Preparation of polymeric sequestrants for bile acid salts.

    Mandeville,
    > : W. H., III.;
    > : > Holmes-
    > : > Farley, S. R.; US 5,703,188; 12/30/97.
    > : >
    > : > 34. Oral administration of iron-binding crosslinked amine polymers.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    > : >
    > : > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley,

    S.
    > : R.; US 5,693,675;
    > : > 12/2/97.
    > : >
    > : > 36. Method for removing bile salts from a patient with alkylated
    > : crosslinked amine
    > : > polymers,
    > : > and preparation of the polymers. Mandeville, W. H., III.;

    Holmes-Farley,
    > : S. R.; US
    > : > 5,679,717; 10/21/97.
    > : >
    > : > 37. Phosphate-binding polymers for oral administration. Holmes-Farley,

    S.
    > : R.; Mandeville,
    > : > W.
    > : > H., III.; US 5,667,775; 9/16/97.
    > : >
    > : > 38. Ion-exchange process using highly crosslinked polymers for

    removing
    > : bile salts from a
    > : > patient, preparation of the polymers, and compositions containing

    them.
    > : Mandeville, W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    > : >
    > : > 39. Hydrophobic amine polymer sequestrant and method of cholesterol
    > : depletion. Mandeville,
    > : > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530;

    4/8/97.
    > : >
    > : > 40. Amine polymer sequestrant and method of cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    > : >
    > : > 41. Phosphate-binding polymers for oral administration. Holmes-Farley,

    S.
    > : R.; Mandeville,
    > : > W.
    > : > H., III.; US 5,496,545; 3/5/96.
    > : >
    > : > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,
    > : III.; Holmes-Farley,
    > : > S. R.;
    > : > US 5,487,888; 1/30/96.
    > : >
    > : > 43. Ultra-thin, uniform sol-gel coating of a substrate having active
    > : hydrogens on the
    > : > surface.
    > : > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    > : >
    > : > 44. Layered sol-gel coatings from organisilicon compounds.

    Holmes-Farley,
    > : S. R.; Yanyo, L.
    > : > C.;
    > : > US 5,182,143; 1/26/93.
    > : >
    > : > 45. Method for metal bonding using ultrathin primer coating.
    > : Holmes-Farley, S. R.; Yanyo,
    > : > L.
    > : > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    > : >
    > : > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.;

    US
    > : 5,096,962;
    > : > 3/17/92.
    > : >
    > : > 47. Modified halogenatedpolyolefin adhesives for polyolefin
    > : elastomer-metal bonding.
    > : > Holmes-
    > : > Farley, S. R.; US 5,102,956; 4/7/92.
    > : >
    > : >
    > : >
    > : > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    > : >
    > : >
    > : > 1. Aryl boronate functionalized polymers for treating obesity and
    > : inhibiting fat uptake.
    > : > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal,

    Pradeep
    > : K.; Huval, Chad
    > : > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92

    pp. WO
    > : 0302571.
    > : >
    > : > 2. Preparation of aryl boronic acids for treating obesity.

    Holmes-Farley,
    > : Stephen Randall;
    > : > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep

    K.
    > : (Geltex
    > : > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    > : >
    > : > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,
    > : Stephen Randall.
    > : > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO
    > : 0302130.
    > : >
    > : > 4. Method for reducing copper levels and treating copper toxicosis.
    > : Holmes-Farley, Stephen
    > : > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002),

    45
    > : pp. WO
    > : > 0285383.
    > : >
    > : > 5. Method for treating gout and binding uric acid. Holmes-Farley,

    Stephen
    > : Randall; Burke,
    > : > Steven K. WO 0285381 10/31/2002.
    > : >
    > : > 6. Method for treating gout and reducing serum uric acid.

    Holmes-Farley,
    > : Stephen Randall;
    > : > Burke, Steven K WO 0285380 10/31/2002.
    > : >
    > : > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;
    > : Holmes-Farley, S. R.;
    > : > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    > : >
    > : > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and
    > : Holmes-Farley, S.
    > : > R.;
    > : > WO 1999-US5662; 9/23/1999.
    > : >
    > : > 9. Amine-containing copolymers as bile acid sequestrants.

    Holmes-Farley,
    > : S. R.; Petersen,
    > : > J. S.;
    > : > WO 9933452; 7/8/1999.
    > : >
    > : > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III

    and
    > : Holmes-Farley, S.
    > : > R.;
    > : > WO 9922743; 5/14/1999.
    > : >
    > : > 11. Polyallylamine polymers for removing bile salts and treating
    > : hypercholesterolemia, and
    > : > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III;

    Burke,
    > : S. K.; Goldberg,
    > : > D. I.; WO 9857652; 12/23/98.
    > : >
    > : > 12. Phosphate-bidning polymers combined with a calcium supplement for

    oral
    > : administration.
    > : > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley,

    S.
    > : R.; WO 9842355;
    > : > 10/1/98.
    > : >
    > : > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol
    > : depletion. Mandeville,
    > : > W.
    > : > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    > : >
    > : > 14. Process for adjusting ion concentration in a patient and

    compositions
    > : therefor.
    > : > Mandeville,
    > : > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    > : >
    > : > 15. Vacuum-deposited silver on polycarbonate with a chromium

    interlayer
    > : for improved
    > : > metal-
    > : > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512;

    1/20/94.
    > : >
    > : > 16. Process for increased metal-substrate bond strength in metalized
    > : plastics.
    > : > Holmes-Farley, S.
    > : > R.; Ger. Offen. 4322516; 7/6/93.
    > : >
    > : > 17. Electrorheological fluids and preparation of particles useful in

    the
    > : fluids.
    > : > Troughton,
    > : > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.
    > : David; Bares, Joseph
    > : > E.;
    > : > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP
    > : 394049;
    > : > 10/24/1990.
    > : >
    > : > JOURNAL PUBLICATIONS
    > : >
    > : > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov,

    Eugene;
    > : Guo, Amy;
    > : > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;
    > : Mandeville, W. Harry;
    > : > Holmes-Farley, S. Randall. Kidney International (2002), 62(2),

    611-619.
    > : >
    > : > 2. Amine functionalized polyethers as bile acid sequestrants:

    synthesis
    > : and biological
    > : > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S.

    Randall;
    > : Mandeville, W.
    > : > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.
    > : Journal of
    > : > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),
    > : 1559-1574.
    > : >
    > : > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular
    > : Imprinting. Huval,
    > : > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.
    > : Randall; Mandeville,
    > : > W.
    > : > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert

    J.;
    > : Chen, Xi; Dhal,
    > : > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    > : >
    > : > 4. Synthetic polymers for the binding of fat in the intestinal tract.
    > : Jozefiak, Thomas H.;
    > : > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia;

    Huval,
    > : Chad C.;
    > : > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.
    > : Abstracts of
    > : > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August
    > : 26-30, 2001
    > : > (2001), POLY-047 and Polymer Preprints (American Chemical Society,
    > : Division of
    > : > Polymer Chemistry) (2001), 42(2), 98.
    > : >
    > : > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer

    gel
    > : pharmaceutical.
    > : > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.;

    Ward,
    > : J.; Sacchiero,
    > : > B.;
    > : > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.;

    Chen,
    > : X.; Mazzeo, J.
    > : > R.. Polym. Preprints (2000), 41(1), 735-736.
    > : >
    > : > 6. In vitro comparison of bile acid binding to colesevelam HCl and

    other
    > : bile acid
    > : > sequestrants.
    > : > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;
    > : Hook, P.; Holmes-
    > : > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    > : >
    > : > 7. Novel polymeric pharmaceuticals: From startup to market.

    Holmes-Farley,
    > : S. R; Polym.
    > : > Mater. Sci. Eng (1999), 80, 246-247.
    > : >
    > : > 8. Design and characterization of of Sevelamer Hydrochloride: a novel
    > : phosphate-binding
    > : > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward,

    J.;
    > : Miller, K. L.;
    > : > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure

    and
    > : Appl. Chem.,
    > : > A36(7&8), p. 1085 (1999).
    > : >
    > : > 9. Three generations of bile acid sequestrants. Mandeville, W. H.,

    III;
    > : Braunlin, W.;
    > : > Dhal, P.;
    > : > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;
    > : Rosenbaum, D.;
    > : > Sacchiero,
    > : > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),
    > : 550, 3-15.
    > : >
    > : > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric

    phosphate
    > : binder, on
    > : > urinary
    > : > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;
    > : Mandeville, W. H.,
    > : > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.
    > : (1997), 12(5)
    > : > 961-964.
    > : >
    > : > 11. Thin anisotropic coatings based on sol-gel technology.

    Holmes-Farley,
    > : S. R.; Yanyo, L.
    > : > C;
    > : > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4),

    439-444.
    > : >
    > : > 12. The mechanism of cure initiation of a surface activated adhesive.
    > : Holmes-Farley, S.
    > : > R.;
    > : > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    > : >
    > : > 13. Adhesion promotion and corrosion prevention using thin anisotropic
    > : coatings. Holmes-
    > : > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),
    > : 131-151.
    > : >
    > : > 14. Wetting of functionalized polyethylene having ionizable organic

    acids
    > : and bases at the
    > : > polymer-water interface: relations between functional group polarity,
    > : extent of
    > : > ionization,
    > : > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;
    > : Whitesides, G. M.;
    > : > Langmuir
    > : > (1988), 4(4), 921-937.
    > : >
    > : > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a
    > : single hydroxy group.
    > : > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    > : >
    > : > 16. Reconstruction of the interface of oxidatively functionalized
    > : polyethylene (PE-CO2H)
    > : > and
    > : > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo,

    R.;
    > : McCarthy, T. J.;
    > : > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report

    (1987),
    > : AD-
    > : > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    > : >
    > : > 17. Surface-modified polyethylene film: the relationship between

    surface
    > : chemistry and
    > : > physical
    > : > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11),

    4537.
    > : >
    > : > 18. Reactivity of carboxylic acid and ester groups in the

    functionalized
    > : interfacial
    > : > region of
    > : > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:
    > : differentiation of the
    > : > functional groups into shallow and deep subsets based on a comparison

    of
    > : contact angle and
    > : > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir
    > : (1987), 3(1), 62-
    > : > 76.
    > : >
    > : > 19. Fluorescence properties of dansyl groups covalently bonded tot he
    > : surface of
    > : > oxidatively
    > : > functionalized low-density polyethylene film. Holmes-Farley, S. R.;
    > : Whitesides, G. M.;
    > : > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;
    > : AD-A162435/2/GAR,
    > : > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    > : >
    > : > 20. Acid-base behavior of carboxylic acid groups covalently attached

    at
    > : the surface of
    > : > polyethylene: The usefulness of contact angle in following the

    ionization
    > : of surface
    > : > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;
    > : Deutch, J.;
    > : > Whitesides,
    > : > G. M.; Langmuir (1985), 1(6), 725-740.
    > : >
    > : > 21. The thermal stability of a surface modified solid organic polymer.
    > : Holmes-Farley, S.
    > : > R.;
    > : > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    > : >
    > : >
    > : >
    > : > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    > : >
    > : > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced
    > : Aquarist. June 2003.
    > : >
    > : > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.
    > : Advanced Aquarist.
    > : > May
    > : > 2003.
    > : >
    > : > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.
    > : Reefkeeping May
    > : > 2003.
    > : >
    > : > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping
    > : April 2003.
    > : >
    > : > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; April 2003.
    > : >
    > : > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; April 2003.
    > : >
    > : > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced

    Aquarist;
    > : March 2003.
    > : >
    > : > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; February 2003.
    > : >
    > : > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January
    > : 2003.
    > : >
    > : > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist;

    December
    > : 2002.
    > : >
    > : > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R.

    Advanced
    > : Aquarist; November
    > : > 2002.
    > : >
    > : > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.
    > : Advanced Aquarist;
    > : > November 2002.
    > : >
    > : > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced

    Aquarist,
    > : September 2002.
    > : >
    > : > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August
    > : 2002.
    > : >
    > : > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April
    > : 2002.
    > : >
    > : > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced
    > : Aquarist; July 2002
    > : >
    > : > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist;

    June
    > : 2002.
    > : >
    > : > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R.

    Advanced
    > : Aquarist, May
    > : > 2002.
    > : >
    > : > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist, April 2002.
    > : >
    > : > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    > : >
    > : > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    > : >
    > : > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January

    2002.
    > : >
    > : > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers
    > : 2000.
    > : >
    > : > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium
    > : Frontiers 2000.
    > : >
    > : > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.
    > : Aquarium Frontiers
    > : > 2000.
    > : > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium

    Frontiers
    > : 2000.
    > : >
    > : > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers

    2000.
    > : >
    > : > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    > : >
    > : > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    > : >
    > : >
    > : >
    > : >
    > : >
    > : >
    > : >
    > : > Boomer
    > : >
    > : > Want to talk chemistry ? The Reef Chemistry Forum
    > : > http://www.reefcentral.com/vbulletin/index.php
    > : >
    > : > Want to See More ?
    > : > Please Join Our Growing Membership
    > : > www.coralrealm.com
    > : >
    > : >
    > : >
    > :
    > :
    >
    >
     
    stoutman, Feb 11, 2004
    #54
  15. Dinky

    stoutman Guest

    >Alkalinity a measure of the amount of anions of weak acid in water and of
    the cations balanced against them
    >Take note it says ***acid***


    Take note, it also says ***bases***

    Acid neutralizing or buffering capacity of water; a measure of the ability
    of water to resist changes in pH caused by the addition of acids or bases



    maybe this is the problem. Boomer do you know what a base is?






    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102kn4e6f2vvb1@corp.supernews.com...
    > Alkalinity a measure of the amount of anions of weak acid in water and of

    the cations
    > balanced against them
    > Take note it says ***acid***
    >
    > Buffering capacity the ability of a solution to resist or dampen changes

    in pH upon the
    > addition of acids or bases.
    > Take note its says ***the addition of acids or bases***
    >
    > One more
    >
    > http://www.waterontheweb.org/resources/glossary.html
    >
    > We could go on like this all day, so what is the point ?
    >
    > You will LOVE this one
    > http://www.kyantec.com/Tips/phbuffering.htm
    >
    > Don't you just lovbe PDF's
    > http://www.inform.umd.edu/manurenet/reprints/98.1702.pdf
    >
    > Don't fall out of your chair
    > http://www.chemforlife.org/teacher/topics/chemistry_in_an_aquarium.htm
    >
    >
    >
    >
    > --
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    > If You See Me Running You Better Catch-Up
    > "stoutman" <.@.> wrote in message news:XB7Wb.19339$QA2.62332@attbi_s52...
    > : Man here is another, google is a wonderful thing. I'm not filtering any
    > : out, just posting what I find by GOOGLING for you.
    > :
    > : http://www.globe.gov/hq/trr_suppl/hydro/HY_SUP_ALK_INTRO_NOTES.HTML
    > :
    > :
    > : Wow, a gov link. Even the government is wrong, this must be a

    conspiracy
    > : against Boomer.
    > :
    > :
    > :
    > :
    > : "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    > : news:102ht0bjplpo059@corp.supernews.com...
    > : > Now I am getting bored
    > : >
    > : > "Don't the components of a buffer account for the buffering capacity?
    > : Yes."
    > : >
    > : > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity

    and
    > : Alkalinity are
    > : > not the same, that has always been the issue. I gave the equation does
    > : that look like an
    > : > Alkalinity equation or how Alk is determined. I see you had now

    comments
    > : on it what's
    > : > wrong, why no comments on the equations I gave. Don't understand them

    or
    > : what ? Again this
    > : > is the equation for Buffering Capacity, also called Buffer Index or

    Buffer
    > : Intensity. It
    > : > is defined in most water chemistry and chemical oceanography text

    books.
    > : >
    > : > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] +

    CKa
    > : [H3O+] / (Ka =
    > : > H3O+])² )
    > : >
    > : > This is not Alkalinity now is it ?
    > : >
    > : > "I know how to do a titration, In fact I have done several. How many

    have
    > : > you actually done? I don't mean by counting drops, I mean with a

    buret?"
    > : >
    > : > Well good for you, I use a Digital Titrator
    > : >
    > : > "Oh, I see,
    > : > you think acidity is the opposite of alkalinity. In the world of
    > : CHEMISTRY
    > : > it's not. Maybe in aquarium newsgroups it is.
    > : >
    > : > Hum no, maybe you should go for a look at HACH's or LaMotte website or

    the
    > : book I
    > : > suggested earlier. Please view a copy.
    > : >
    > : > Standard Methods for the Examination of Water and Wastewater
    > : >
    > : > This book, over 2000 pages, is the guide for water testing. If you are
    > : reporting water
    > : > test to the EPA you must use approved std from this text.I t is

    prepared
    > : and published by
    > : > the EPA, American Water Works Association and American Public Health
    > : Association. You
    > : > mean you don't have one and the issue is water chemistry
    > : >
    > : > You are confusing Acidity and Acidity as you know little about water
    > : chemistry and
    > : > procedures and test methods
    > : >
    > : > From SMEWW, section 2-30, 2310 ACIDITY
    > : >
    > : > "Acidity of water is its quantative capacity to react with a strong

    base
    > : to a designated
    > : > pH"
    > : >
    > : > This is how you test for it
    > : >
    > : > A std alkali titration to methyl orange or phenolphthalein
    > : > endpoint.
    > : >
    > : > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write

    this
    > : book, there are
    > : > over 100 of them, they are wrong.
    > : >
    > : > Like Buffering Capacity you have your Acidity's mixed up
    > : > In water measurement if you have a high Alk you also usually have a

    high
    > : Acidity.
    > : > Normally a high Alk also gives a higher CO2 level. Get a WATER

    CHEMISTRY
    > : BOOK there pal.
    > : >
    > : >
    > : > "These are all in equilibrium with each other. An initial high pH

    (above
    > : > 6.4) will shift the equilibrium to the right to form HCO3-1. If the

    pH of
    > : > the solution is above 10.3 (pKa2) the .........."
    > : >
    > : >
    > : > Christ, there you go again with the FW shit. All your numbers are

    wrong we
    > : are dealing
    > : > with SEAWATER
    > : >
    > : > This means that at a pH of 8.3, the majority of the CO2(aq) is in the

    form
    > : > of HCO3-1 .
    > : >
    > : > I have already pointed that out and gave actual values at know

    seawater
    > : levels, go back
    > : > and re-read it you aren't telling me anything here.Of course most is

    HCO3
    > : see...
    > : >
    > : >
    > : > @ 20C and 34.3 ppt salinity
    > : >
    > : > CO2 = 0.52 %
    > : >
    > : > HCO3 = 86.4 %
    > : >
    > : > CO3 = 13.09 %
    > : >
    > : >
    > : > "In your glass experiment you managed to lower the pH enough to purge

    out
    > : CO2
    > : > by boiling"
    > : >
    > : > The purpose behind the glass is to show that alk is not affect by CO2

    and
    > : vise-versa and
    > : > how Co2 affects pH.
    > : >
    > : > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH

    drops
    > : to say 8.1 it is
    > : > usually due to excess CO2. If you took a glass of that water and

    aerated
    > : it you WILL drive
    > : > off the CO2 and raise the pH. It has been done a proven a million

    times.
    > : >
    > : > "In order to 'purge' CO2 you would need to lower the
    > : > pH to shift the equilibrium to below 6.4"
    > : >
    > : > The hell you do !!!.Do you know who many times people on this NG to
    > : include Dr. Craig
    > : > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a
    > : sample of aquarium
    > : > water and aerate it to see if the pH GOES UP AND when they come back

    with
    > : the test it is
    > : > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST

    excess
    > : CO2 in the tank
    > : > water, increase the circulation for better gas exchange at the

    surface,
    > : reduce feeding,
    > : > and try to improve on better skimming, thus reducing the bio-load and

    pH
    > : decline due to
    > : > CO2.
    > : >
    > : >
    > : > "I hope this helps. "
    > : >
    > : > Help, how can you when you miss everything. I should be charging you
    > : >
    > : > Oh, by the way. Your websites, I have about 50 on these issues, I

    could
    > : post them, not to
    > : > mention I have all those water chemistry books, so there is no need to
    > : view your sites.
    > : >
    > : > Finally are you afraid to come to our Chemistry Forum, afraid to get
    > : slapped by REAL
    > : > chemists. I get a charge out of you can't post your ref .I have posted

    the
    > : same or similar
    > : > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500

    posts
    > : there and am the
    > : > biggest contributor to his forum other than himself or maybe Habib

    Sheka
    > : >
    > : > Hum, here are Randy's ref that he posted. He hosts the website
    > : >
    > : > S. RANDY HOLMES-FARLEY
    > : > Arlington, Massachusetts
    > : >
    > : > EDUCATION
    > : >
    > : > 1982-1986 Harvard University Cambridge, MA
    > : > PhD in Chemistry
    > : > Research Advisor: George Whitesides
    > : >
    > : > Investigated the relationship between polymer surface chemistry and
    > : physical properties
    > : > through controlled surface modification and testing.
    > : >
    > : > 1980-1982 Cornell University Ithaca, NY
    > : > BA in Chemistry and Biology
    > : > Graduated Summa Cum Laude
    > : > Distinction in All Subjects
    > : > Grade Point: 3.94/4.0
    > : > Honors research: isolation and characterization of the subunit of CF1
    > : enzyme
    > : >
    > : >
    > : > 1978-1979 Stanford University Palo Alto, CA
    > : > Grade Point: 3.55/4.0
    > : >
    > : >
    > : > EXPERIENCE
    > : >
    > : > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > : > (bought out GelTex Pharmaceuticals in 2001)
    > : > Vice President, Chemical Research 2001-present
    > : > Senior Director, Chemical Research 1999-2001
    > : > Director of Chemical Research 1997-1999
    > : > Manager of Chemical Research 1995-1997
    > : > Group Leader 1994-1995
    > : > Senior Research Scientist 1992-1994
    > : >
    > : > Helped start GelTex as second employee
    > : >
    > : > Managed various research programs with multi-million dollar budgets
    > : >
    > : > Supervised research chemists (17+)
    > : >
    > : > Co-inventor of several polymeric pharmaceuticals and pharmaceutical
    > : candidates including
    > : > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride

    (FDA
    > : approved)
    > : >
    > : > Company Safety Officer for 3 years
    > : >
    > : > Chemical Hygiene Officer 2000-present
    > : >
    > : >
    > : >
    > : >
    > : > 1990-1992 GTE Corporation Waltham, MA
    > : > Senior Member of Technical Staff
    > : > Applied research involving polymer interfaces
    > : > Metallization of plastics
    > : > Polymer/polymer adhesion
    > : > Optical coatings
    > : >
    > : >
    > : >
    > : > 1986-1990 Lord Corporation Cary, NC
    > : > Senior Research Scientist 1988-1990
    > : > Research Scientist 1986-1988
    > : > Basic and applied research on surface chemical bonding
    > : > Developed new adhesive compositions
    > : > Developed new sol-gel coatings for corrosion resistance
    > : >
    > : >
    > : > HONORS AND AWARDS
    > : >
    > : > Industrial Innovations Award by Northeast Region of American Chemical
    > : Society (6/2001)
    > : >
    > : > National Kidney Foundation of Northern California Honoree (5/2001)
    > : >
    > : > American Chemical Society/Polymer Chemistry Division Industrial

    Sponsors
    > : > Award (8/2000)
    > : >
    > : > R&D 100 Award from R&D magazine (1999)
    > : >
    > : > Sherwin Williams Award in applied polymer science (9/85)
    > : >
    > : > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    > : >
    > : > Award for highest GPA in Chemistry Department (6/82)
    > : >
    > : > Summa Cum Laude Honors in Chemistry (6/82)
    > : >
    > : > Phi Lamda Epsilon (6/82)
    > : >
    > : > Phi Beta Kappa (2/82)
    > : >
    > : > Cornell University Dean's List (1981, 1982)
    > : >
    > : > Harvard Book Club Award for highest GPA senior year (1978)
    > : >
    > : > First Place in western NY ACS high school chemistry exam (1977)
    > : >
    > : > 1978-1979
    > : >
    > : >
    > : > __________________
    > : > Randy Holmes-Farley
    > : > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    > : >
    > : > Hobby Experience: 8 years with reefs
    > : > Current Tanks: 90 gal mixed reef
    > : > Interests: Reefkeeping, science, photography
    > : >
    > : >
    > : > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    > : >
    > : > Open this post in a new window | Report this post to a moderator | IP:
    > : Logged
    > : >
    > : >
    > : >
    > : > 06/27/2003 02:44 PM
    > : >
    > : > Randy Holmes-Farley
    > : > Chemistry Moderator
    > : >
    > : > Registered: Apr 2001
    > : > Location: Arlington, Massachusetts
    > : > Occupation: Chemist (Drug Discovery at Genzyme)
    > : > Posts: 15282
    > : >
    > : >
    > : >
    > : > Publications
    > : >
    > : >
    > : > ISSUED UNITED STATES PATENTS
    > : >
    > : >
    > : > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;
    > : Mandeville, III; W. Harry.
    > : > US 6,566,407; 5/20/2003
    > : >
    > : > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen

    Randall;
    > : Huval, Chad
    > : > Cori.
    > : > U.S. 6,517,825; 2/11/2003.
    > : >
    > : > 3. Method of making phosphate-binding polymers for oral

    administration.
    > : Holmes-Farley,
    > : > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.
    > : 6,509,013; 1/21/2003.
    > : >
    > : > 4. Combination therapy for treating hypercholesterolemia using a bile

    acid
    > : sequestrant
    > : > polymer
    > : > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley,

    Stephen
    > : Randall;
    > : > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    > : >
    > : > 5. Method for treating hypercholesterolemia with polyallylamine

    polymers.
    > : Holmes-Farley,
    > : > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.;

    Goldberg,
    > : Dennis I. , US
    > : > 6,423,754; 7/23/2002.
    > : >
    > : > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;
    > : Neenan, Thomas X..;
    > : > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    > : >
    > : > 7. Combination therapy for treating hypercholesterolemia and
    > : atherosclerosis. Huval, Chad
    > : > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep

    K.
    > : U.S. 6,365,186;
    > : > 4/2/2002.
    > : >
    > : > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.;

    Mandeville,
    > : W. H., III;
    > : > Huval; C.
    > : > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;
    > : 10/9/2001.
    > : >
    > : > 9. Polymers containing guanidinium groups as bile acid sequestrants.

    Dhal;
    > : P. K.; Holmes-
    > : > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    > : >
    > : > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 6,281,252;
    > : > 8/28/2001.
    > : >
    > : > 11. Combination therapy for treating hypercholestrolemia. Huval; C.

    C.;
    > : Holmes-Farley; S.
    > : > R. ;
    > : > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    > : >
    > : > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;
    > : Holmes-Farley, S.
    > : > R.; US
    > : > 6,264,937; 7/24/2001.
    > : >
    > : > 13. Method for treating hypercholesterolemia with unsubstituted
    > : polydiallylamine polymers.
    > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    > : 6,248,318;
    > : > 6/19/2001.
    > : >
    > : > 14. Process for removing bile salts from a patient and alkylated
    > : compositions therefore.
    > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    > : >
    > : > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S.

    R.;
    > : Dhal, P. K.;
    > : > Petersen,
    > : > J. S.; US 6,203,785; 3/20/2001.
    > : >
    > : > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.;

    Huval,
    > : C. C.; US
    > : > 6,190,649;
    > : > 2/20/2001.
    > : >
    > : > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 6,177,478;
    > : > 1/23/2001.
    > : >
    > : > 18. Water-insoluble noncrosslinked bile acid sequestrants.

    Holmes-Farley,
    > : S. R.;
    > : > Mandeville, W.
    > : > H., III.; US 6,129,910; 10/10/2000.
    > : >
    > : > 19. Method for treating hypercholesterolemia with unsubstituted
    > : polydiallylamine polymers.
    > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    > : 6,083,497;
    > : > 7/4/2000.
    > : >
    > : > 20. Method of making phosphate-binding polymers for oral

    administration.
    > : Holmes-Farley, S.
    > : > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495;

    7/4/2000.
    > : >
    > : > 21. Process for removing bile salts from a patient and alkylated
    > : compositions therefore.
    > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678;

    5/23/2000.
    > : >
    > : > 22. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    > : >
    > : > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;
    > : Neenan; T. X.; Holmes-
    > : > Farley; S. R. US 6,034,129; 3/7/2000.
    > : >
    > : > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 5,985,938;
    > : > 11/16/99.
    > : >
    > : > 25. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    > : >
    > : > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W.

    H.,
    > : III.;
    > : > Holmes-Farley;
    > : > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    > : >
    > : > 27. Hydrophilic nonamine-containing and amine-containing copolymers

    and
    > : their use as bile
    > : > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US

    5,929,184;
    > : 7/27/99.
    > : >
    > : > 28. Interpenetrating polymer networks for sequestration of bile acids.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;
    > : 7/20/99.
    > : >
    > : > 29. Amine polymer sequestrant and method of cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    > : >
    > : > 30. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    > : >
    > : > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    > : >
    > : > 32. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    > : >
    > : > 33. Preparation of polymeric sequestrants for bile acid salts.

    Mandeville,
    > : W. H., III.;
    > : > Holmes-
    > : > Farley, S. R.; US 5,703,188; 12/30/97.
    > : >
    > : > 34. Oral administration of iron-binding crosslinked amine polymers.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    > : >
    > : > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley,

    S.
    > : R.; US 5,693,675;
    > : > 12/2/97.
    > : >
    > : > 36. Method for removing bile salts from a patient with alkylated
    > : crosslinked amine
    > : > polymers,
    > : > and preparation of the polymers. Mandeville, W. H., III.;

    Holmes-Farley,
    > : S. R.; US
    > : > 5,679,717; 10/21/97.
    > : >
    > : > 37. Phosphate-binding polymers for oral administration. Holmes-Farley,

    S.
    > : R.; Mandeville,
    > : > W.
    > : > H., III.; US 5,667,775; 9/16/97.
    > : >
    > : > 38. Ion-exchange process using highly crosslinked polymers for

    removing
    > : bile salts from a
    > : > patient, preparation of the polymers, and compositions containing

    them.
    > : Mandeville, W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    > : >
    > : > 39. Hydrophobic amine polymer sequestrant and method of cholesterol
    > : depletion. Mandeville,
    > : > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530;

    4/8/97.
    > : >
    > : > 40. Amine polymer sequestrant and method of cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    > : >
    > : > 41. Phosphate-binding polymers for oral administration. Holmes-Farley,

    S.
    > : R.; Mandeville,
    > : > W.
    > : > H., III.; US 5,496,545; 3/5/96.
    > : >
    > : > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,
    > : III.; Holmes-Farley,
    > : > S. R.;
    > : > US 5,487,888; 1/30/96.
    > : >
    > : > 43. Ultra-thin, uniform sol-gel coating of a substrate having active
    > : hydrogens on the
    > : > surface.
    > : > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    > : >
    > : > 44. Layered sol-gel coatings from organisilicon compounds.

    Holmes-Farley,
    > : S. R.; Yanyo, L.
    > : > C.;
    > : > US 5,182,143; 1/26/93.
    > : >
    > : > 45. Method for metal bonding using ultrathin primer coating.
    > : Holmes-Farley, S. R.; Yanyo,
    > : > L.
    > : > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    > : >
    > : > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.;

    US
    > : 5,096,962;
    > : > 3/17/92.
    > : >
    > : > 47. Modified halogenatedpolyolefin adhesives for polyolefin
    > : elastomer-metal bonding.
    > : > Holmes-
    > : > Farley, S. R.; US 5,102,956; 4/7/92.
    > : >
    > : >
    > : >
    > : > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    > : >
    > : >
    > : > 1. Aryl boronate functionalized polymers for treating obesity and
    > : inhibiting fat uptake.
    > : > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal,

    Pradeep
    > : K.; Huval, Chad
    > : > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92

    pp. WO
    > : 0302571.
    > : >
    > : > 2. Preparation of aryl boronic acids for treating obesity.

    Holmes-Farley,
    > : Stephen Randall;
    > : > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep

    K.
    > : (Geltex
    > : > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    > : >
    > : > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,
    > : Stephen Randall.
    > : > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO
    > : 0302130.
    > : >
    > : > 4. Method for reducing copper levels and treating copper toxicosis.
    > : Holmes-Farley, Stephen
    > : > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002),

    45
    > : pp. WO
    > : > 0285383.
    > : >
    > : > 5. Method for treating gout and binding uric acid. Holmes-Farley,

    Stephen
    > : Randall; Burke,
    > : > Steven K. WO 0285381 10/31/2002.
    > : >
    > : > 6. Method for treating gout and reducing serum uric acid.

    Holmes-Farley,
    > : Stephen Randall;
    > : > Burke, Steven K WO 0285380 10/31/2002.
    > : >
    > : > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;
    > : Holmes-Farley, S. R.;
    > : > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    > : >
    > : > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and
    > : Holmes-Farley, S.
    > : > R.;
    > : > WO 1999-US5662; 9/23/1999.
    > : >
    > : > 9. Amine-containing copolymers as bile acid sequestrants.

    Holmes-Farley,
    > : S. R.; Petersen,
    > : > J. S.;
    > : > WO 9933452; 7/8/1999.
    > : >
    > : > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III

    and
    > : Holmes-Farley, S.
    > : > R.;
    > : > WO 9922743; 5/14/1999.
    > : >
    > : > 11. Polyallylamine polymers for removing bile salts and treating
    > : hypercholesterolemia, and
    > : > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III;

    Burke,
    > : S. K.; Goldberg,
    > : > D. I.; WO 9857652; 12/23/98.
    > : >
    > : > 12. Phosphate-bidning polymers combined with a calcium supplement for

    oral
    > : administration.
    > : > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley,

    S.
    > : R.; WO 9842355;
    > : > 10/1/98.
    > : >
    > : > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol
    > : depletion. Mandeville,
    > : > W.
    > : > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    > : >
    > : > 14. Process for adjusting ion concentration in a patient and

    compositions
    > : therefor.
    > : > Mandeville,
    > : > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    > : >
    > : > 15. Vacuum-deposited silver on polycarbonate with a chromium

    interlayer
    > : for improved
    > : > metal-
    > : > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512;

    1/20/94.
    > : >
    > : > 16. Process for increased metal-substrate bond strength in metalized
    > : plastics.
    > : > Holmes-Farley, S.
    > : > R.; Ger. Offen. 4322516; 7/6/93.
    > : >
    > : > 17. Electrorheological fluids and preparation of particles useful in

    the
    > : fluids.
    > : > Troughton,
    > : > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.
    > : David; Bares, Joseph
    > : > E.;
    > : > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP
    > : 394049;
    > : > 10/24/1990.
    > : >
    > : > JOURNAL PUBLICATIONS
    > : >
    > : > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov,

    Eugene;
    > : Guo, Amy;
    > : > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;
    > : Mandeville, W. Harry;
    > : > Holmes-Farley, S. Randall. Kidney International (2002), 62(2),

    611-619.
    > : >
    > : > 2. Amine functionalized polyethers as bile acid sequestrants:

    synthesis
    > : and biological
    > : > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S.

    Randall;
    > : Mandeville, W.
    > : > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.
    > : Journal of
    > : > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),
    > : 1559-1574.
    > : >
    > : > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular
    > : Imprinting. Huval,
    > : > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.
    > : Randall; Mandeville,
    > : > W.
    > : > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert

    J.;
    > : Chen, Xi; Dhal,
    > : > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    > : >
    > : > 4. Synthetic polymers for the binding of fat in the intestinal tract.
    > : Jozefiak, Thomas H.;
    > : > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia;

    Huval,
    > : Chad C.;
    > : > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.
    > : Abstracts of
    > : > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August
    > : 26-30, 2001
    > : > (2001), POLY-047 and Polymer Preprints (American Chemical Society,
    > : Division of
    > : > Polymer Chemistry) (2001), 42(2), 98.
    > : >
    > : > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer

    gel
    > : pharmaceutical.
    > : > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.;

    Ward,
    > : J.; Sacchiero,
    > : > B.;
    > : > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.;

    Chen,
    > : X.; Mazzeo, J.
    > : > R.. Polym. Preprints (2000), 41(1), 735-736.
    > : >
    > : > 6. In vitro comparison of bile acid binding to colesevelam HCl and

    other
    > : bile acid
    > : > sequestrants.
    > : > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;
    > : Hook, P.; Holmes-
    > : > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    > : >
    > : > 7. Novel polymeric pharmaceuticals: From startup to market.

    Holmes-Farley,
    > : S. R; Polym.
    > : > Mater. Sci. Eng (1999), 80, 246-247.
    > : >
    > : > 8. Design and characterization of of Sevelamer Hydrochloride: a novel
    > : phosphate-binding
    > : > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward,

    J.;
    > : Miller, K. L.;
    > : > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure

    and
    > : Appl. Chem.,
    > : > A36(7&8), p. 1085 (1999).
    > : >
    > : > 9. Three generations of bile acid sequestrants. Mandeville, W. H.,

    III;
    > : Braunlin, W.;
    > : > Dhal, P.;
    > : > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;
    > : Rosenbaum, D.;
    > : > Sacchiero,
    > : > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),
    > : 550, 3-15.
    > : >
    > : > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric

    phosphate
    > : binder, on
    > : > urinary
    > : > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;
    > : Mandeville, W. H.,
    > : > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.
    > : (1997), 12(5)
    > : > 961-964.
    > : >
    > : > 11. Thin anisotropic coatings based on sol-gel technology.

    Holmes-Farley,
    > : S. R.; Yanyo, L.
    > : > C;
    > : > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4),

    439-444.
    > : >
    > : > 12. The mechanism of cure initiation of a surface activated adhesive.
    > : Holmes-Farley, S.
    > : > R.;
    > : > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    > : >
    > : > 13. Adhesion promotion and corrosion prevention using thin anisotropic
    > : coatings. Holmes-
    > : > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),
    > : 131-151.
    > : >
    > : > 14. Wetting of functionalized polyethylene having ionizable organic

    acids
    > : and bases at the
    > : > polymer-water interface: relations between functional group polarity,
    > : extent of
    > : > ionization,
    > : > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;
    > : Whitesides, G. M.;
    > : > Langmuir
    > : > (1988), 4(4), 921-937.
    > : >
    > : > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a
    > : single hydroxy group.
    > : > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    > : >
    > : > 16. Reconstruction of the interface of oxidatively functionalized
    > : polyethylene (PE-CO2H)
    > : > and
    > : > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo,

    R.;
    > : McCarthy, T. J.;
    > : > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report

    (1987),
    > : AD-
    > : > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    > : >
    > : > 17. Surface-modified polyethylene film: the relationship between

    surface
    > : chemistry and
    > : > physical
    > : > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11),

    4537.
    > : >
    > : > 18. Reactivity of carboxylic acid and ester groups in the

    functionalized
    > : interfacial
    > : > region of
    > : > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:
    > : differentiation of the
    > : > functional groups into shallow and deep subsets based on a comparison

    of
    > : contact angle and
    > : > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir
    > : (1987), 3(1), 62-
    > : > 76.
    > : >
    > : > 19. Fluorescence properties of dansyl groups covalently bonded tot he
    > : surface of
    > : > oxidatively
    > : > functionalized low-density polyethylene film. Holmes-Farley, S. R.;
    > : Whitesides, G. M.;
    > : > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;
    > : AD-A162435/2/GAR,
    > : > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    > : >
    > : > 20. Acid-base behavior of carboxylic acid groups covalently attached

    at
    > : the surface of
    > : > polyethylene: The usefulness of contact angle in following the

    ionization
    > : of surface
    > : > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;
    > : Deutch, J.;
    > : > Whitesides,
    > : > G. M.; Langmuir (1985), 1(6), 725-740.
    > : >
    > : > 21. The thermal stability of a surface modified solid organic polymer.
    > : Holmes-Farley, S.
    > : > R.;
    > : > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    > : >
    > : >
    > : >
    > : > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    > : >
    > : > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced
    > : Aquarist. June 2003.
    > : >
    > : > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.
    > : Advanced Aquarist.
    > : > May
    > : > 2003.
    > : >
    > : > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.
    > : Reefkeeping May
    > : > 2003.
    > : >
    > : > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping
    > : April 2003.
    > : >
    > : > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; April 2003.
    > : >
    > : > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; April 2003.
    > : >
    > : > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced

    Aquarist;
    > : March 2003.
    > : >
    > : > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; February 2003.
    > : >
    > : > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January
    > : 2003.
    > : >
    > : > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist;

    December
    > : 2002.
    > : >
    > : > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R.

    Advanced
    > : Aquarist; November
    > : > 2002.
    > : >
    > : > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.
    > : Advanced Aquarist;
    > : > November 2002.
    > : >
    > : > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced

    Aquarist,
    > : September 2002.
    > : >
    > : > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August
    > : 2002.
    > : >
    > : > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April
    > : 2002.
    > : >
    > : > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced
    > : Aquarist; July 2002
    > : >
    > : > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist;

    June
    > : 2002.
    > : >
    > : > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R.

    Advanced
    > : Aquarist, May
    > : > 2002.
    > : >
    > : > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist, April 2002.
    > : >
    > : > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    > : >
    > : > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    > : >
    > : > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January

    2002.
    > : >
    > : > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers
    > : 2000.
    > : >
    > : > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium
    > : Frontiers 2000.
    > : >
    > : > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.
    > : Aquarium Frontiers
    > : > 2000.
    > : > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium

    Frontiers
    > : 2000.
    > : >
    > : > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers

    2000.
    > : >
    > : > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    > : >
    > : > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    > : >
    > : >
    > : >
    > : >
    > : >
    > : >
    > : >
    > : > Boomer
    > : >
    > : > Want to talk chemistry ? The Reef Chemistry Forum
    > : > http://www.reefcentral.com/vbulletin/index.php
    > : >
    > : > Want to See More ?
    > : > Please Join Our Growing Membership
    > : > www.coralrealm.com
    > : >
    > : >
    > : >
    > :
    > :
    >
    >
     
    stoutman, Feb 11, 2004
    #55
  16. Dinky

    stoutman Guest

    Good one Dragon Slayer. Do people STILL play D&D?????????????


    "Dragon Slayer" <koi_man@nospam_hotmail.com> wrote in message
    news:c0do6n$b1dp$1@news3.infoave.net...
    >
    > "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    > news:102kk02ji5nc606@corp.supernews.com...
    >
    >
    > > Do a dam search on them or shut the hell up.

    >
    > I'll second that.
    >
    > kc
    >
    >
     
    stoutman, Feb 11, 2004
    #56
  17. Dinky

    stoutman Guest

    I want sure were you got that from, but I see now.

    My reply is response to your CITED WEB PAGE's definition of alkalinity.

    Alkalinity:
    Acid neutralizing or buffering capacity of water; a measure of the ability
    of water to resist changes in pH caused by the addition of acids or bases




    "stoutman" <.@.> wrote in message news:1YuWb.273293$I06.2926488@attbi_s01...
    > >Alkalinity a measure of the amount of anions of weak acid in water and of

    > the cations balanced against them
    > >Take note it says ***acid***

    >
    > Take note, it also says ***bases***
    >
    > Acid neutralizing or buffering capacity of water; a measure of the ability
    > of water to resist changes in pH caused by the addition of acids or bases
    >
    >
    >
    > maybe this is the problem. Boomer do you know what a base is?
    >
    >
    >
    >
    >
    >
    > "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    > news:102kn4e6f2vvb1@corp.supernews.com...
    > > Alkalinity a measure of the amount of anions of weak acid in water and

    of
    > the cations
    > > balanced against them
    > > Take note it says ***acid***
    > >
    > > Buffering capacity the ability of a solution to resist or dampen changes

    > in pH upon the
    > > addition of acids or bases.
    > > Take note its says ***the addition of acids or bases***
    > >
    > > One more
    > >
    > > http://www.waterontheweb.org/resources/glossary.html
    > >
    > > We could go on like this all day, so what is the point ?
    > >
    > > You will LOVE this one
    > > http://www.kyantec.com/Tips/phbuffering.htm
    > >
    > > Don't you just lovbe PDF's
    > > http://www.inform.umd.edu/manurenet/reprints/98.1702.pdf
    > >
    > > Don't fall out of your chair
    > > http://www.chemforlife.org/teacher/topics/chemistry_in_an_aquarium.htm
    > >
    > >
    > >
    > >
    > > --
    > > Boomer
    > >
    > > Want to talk chemistry ? The Reef Chemistry Forum
    > > http://www.reefcentral.com/vbulletin/index.php
    > >
    > > Want to See More ?
    > > Please Join Our Growing Membership
    > > www.coralrealm.com
    > >
    > > If You See Me Running You Better Catch-Up
    > > "stoutman" <.@.> wrote in message

    news:XB7Wb.19339$QA2.62332@attbi_s52...
    > > : Man here is another, google is a wonderful thing. I'm not filtering

    any
    > > : out, just posting what I find by GOOGLING for you.
    > > :
    > > : http://www.globe.gov/hq/trr_suppl/hydro/HY_SUP_ALK_INTRO_NOTES.HTML
    > > :
    > > :
    > > : Wow, a gov link. Even the government is wrong, this must be a

    > conspiracy
    > > : against Boomer.
    > > :
    > > :
    > > :
    > > :
    > > : "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    > > : news:102ht0bjplpo059@corp.supernews.com...
    > > : > Now I am getting bored
    > > : >
    > > : > "Don't the components of a buffer account for the buffering

    capacity?
    > > : Yes."
    > > : >
    > > : > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity

    > and
    > > : Alkalinity are
    > > : > not the same, that has always been the issue. I gave the equation

    does
    > > : that look like an
    > > : > Alkalinity equation or how Alk is determined. I see you had now

    > comments
    > > : on it what's
    > > : > wrong, why no comments on the equations I gave. Don't understand

    them
    > or
    > > : what ? Again this
    > > : > is the equation for Buffering Capacity, also called Buffer Index or

    > Buffer
    > > : Intensity. It
    > > : > is defined in most water chemistry and chemical oceanography text

    > books.
    > > : >
    > > : > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] +

    > CKa
    > > : [H3O+] / (Ka =
    > > : > H3O+])² )
    > > : >
    > > : > This is not Alkalinity now is it ?
    > > : >
    > > : > "I know how to do a titration, In fact I have done several. How

    many
    > have
    > > : > you actually done? I don't mean by counting drops, I mean with a

    > buret?"
    > > : >
    > > : > Well good for you, I use a Digital Titrator
    > > : >
    > > : > "Oh, I see,
    > > : > you think acidity is the opposite of alkalinity. In the world of
    > > : CHEMISTRY
    > > : > it's not. Maybe in aquarium newsgroups it is.
    > > : >
    > > : > Hum no, maybe you should go for a look at HACH's or LaMotte website

    or
    > the
    > > : book I
    > > : > suggested earlier. Please view a copy.
    > > : >
    > > : > Standard Methods for the Examination of Water and Wastewater
    > > : >
    > > : > This book, over 2000 pages, is the guide for water testing. If you

    are
    > > : reporting water
    > > : > test to the EPA you must use approved std from this text.I t is

    > prepared
    > > : and published by
    > > : > the EPA, American Water Works Association and American Public Health
    > > : Association. You
    > > : > mean you don't have one and the issue is water chemistry
    > > : >
    > > : > You are confusing Acidity and Acidity as you know little about water
    > > : chemistry and
    > > : > procedures and test methods
    > > : >
    > > : > From SMEWW, section 2-30, 2310 ACIDITY
    > > : >
    > > : > "Acidity of water is its quantative capacity to react with a strong

    > base
    > > : to a designated
    > > : > pH"
    > > : >
    > > : > This is how you test for it
    > > : >
    > > : > A std alkali titration to methyl orange or phenolphthalein
    > > : > endpoint.
    > > : >
    > > : > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write

    > this
    > > : book, there are
    > > : > over 100 of them, they are wrong.
    > > : >
    > > : > Like Buffering Capacity you have your Acidity's mixed up
    > > : > In water measurement if you have a high Alk you also usually have a

    > high
    > > : Acidity.
    > > : > Normally a high Alk also gives a higher CO2 level. Get a WATER

    > CHEMISTRY
    > > : BOOK there pal.
    > > : >
    > > : >
    > > : > "These are all in equilibrium with each other. An initial high pH

    > (above
    > > : > 6.4) will shift the equilibrium to the right to form HCO3-1. If the

    > pH of
    > > : > the solution is above 10.3 (pKa2) the .........."
    > > : >
    > > : >
    > > : > Christ, there you go again with the FW shit. All your numbers are

    > wrong we
    > > : are dealing
    > > : > with SEAWATER
    > > : >
    > > : > This means that at a pH of 8.3, the majority of the CO2(aq) is in

    the
    > form
    > > : > of HCO3-1 .
    > > : >
    > > : > I have already pointed that out and gave actual values at know

    > seawater
    > > : levels, go back
    > > : > and re-read it you aren't telling me anything here.Of course most is

    > HCO3
    > > : see...
    > > : >
    > > : >
    > > : > @ 20C and 34.3 ppt salinity
    > > : >
    > > : > CO2 = 0.52 %
    > > : >
    > > : > HCO3 = 86.4 %
    > > : >
    > > : > CO3 = 13.09 %
    > > : >
    > > : >
    > > : > "In your glass experiment you managed to lower the pH enough to

    purge
    > out
    > > : CO2
    > > : > by boiling"
    > > : >
    > > : > The purpose behind the glass is to show that alk is not affect by

    CO2
    > and
    > > : vise-versa and
    > > : > how Co2 affects pH.
    > > : >
    > > : > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH

    > drops
    > > : to say 8.1 it is
    > > : > usually due to excess CO2. If you took a glass of that water and

    > aerated
    > > : it you WILL drive
    > > : > off the CO2 and raise the pH. It has been done a proven a million

    > times.
    > > : >
    > > : > "In order to 'purge' CO2 you would need to lower the
    > > : > pH to shift the equilibrium to below 6.4"
    > > : >
    > > : > The hell you do !!!.Do you know who many times people on this NG to
    > > : include Dr. Craig
    > > : > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take

    a
    > > : sample of aquarium
    > > : > water and aerate it to see if the pH GOES UP AND when they come back

    > with
    > > : the test it is
    > > : > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST

    > excess
    > > : CO2 in the tank
    > > : > water, increase the circulation for better gas exchange at the

    > surface,
    > > : reduce feeding,
    > > : > and try to improve on better skimming, thus reducing the bio-load

    and
    > pH
    > > : decline due to
    > > : > CO2.
    > > : >
    > > : >
    > > : > "I hope this helps. "
    > > : >
    > > : > Help, how can you when you miss everything. I should be charging you
    > > : >
    > > : > Oh, by the way. Your websites, I have about 50 on these issues, I

    > could
    > > : post them, not to
    > > : > mention I have all those water chemistry books, so there is no need

    to
    > > : view your sites.
    > > : >
    > > : > Finally are you afraid to come to our Chemistry Forum, afraid to get
    > > : slapped by REAL
    > > : > chemists. I get a charge out of you can't post your ref .I have

    posted
    > the
    > > : same or similar
    > > : > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500

    > posts
    > > : there and am the
    > > : > biggest contributor to his forum other than himself or maybe Habib

    > Sheka
    > > : >
    > > : > Hum, here are Randy's ref that he posted. He hosts the website
    > > : >
    > > : > S. RANDY HOLMES-FARLEY
    > > : > Arlington, Massachusetts
    > > : >
    > > : > EDUCATION
    > > : >
    > > : > 1982-1986 Harvard University Cambridge, MA
    > > : > PhD in Chemistry
    > > : > Research Advisor: George Whitesides
    > > : >
    > > : > Investigated the relationship between polymer surface chemistry and
    > > : physical properties
    > > : > through controlled surface modification and testing.
    > > : >
    > > : > 1980-1982 Cornell University Ithaca, NY
    > > : > BA in Chemistry and Biology
    > > : > Graduated Summa Cum Laude
    > > : > Distinction in All Subjects
    > > : > Grade Point: 3.94/4.0
    > > : > Honors research: isolation and characterization of the subunit of

    CF1
    > > : enzyme
    > > : >
    > > : >
    > > : > 1978-1979 Stanford University Palo Alto, CA
    > > : > Grade Point: 3.55/4.0
    > > : >
    > > : >
    > > : > EXPERIENCE
    > > : >
    > > : > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > > : > (bought out GelTex Pharmaceuticals in 2001)
    > > : > Vice President, Chemical Research 2001-present
    > > : > Senior Director, Chemical Research 1999-2001
    > > : > Director of Chemical Research 1997-1999
    > > : > Manager of Chemical Research 1995-1997
    > > : > Group Leader 1994-1995
    > > : > Senior Research Scientist 1992-1994
    > > : >
    > > : > Helped start GelTex as second employee
    > > : >
    > > : > Managed various research programs with multi-million dollar budgets
    > > : >
    > > : > Supervised research chemists (17+)
    > > : >
    > > : > Co-inventor of several polymeric pharmaceuticals and pharmaceutical
    > > : candidates including
    > > : > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride

    > (FDA
    > > : approved)
    > > : >
    > > : > Company Safety Officer for 3 years
    > > : >
    > > : > Chemical Hygiene Officer 2000-present
    > > : >
    > > : >
    > > : >
    > > : >
    > > : > 1990-1992 GTE Corporation Waltham, MA
    > > : > Senior Member of Technical Staff
    > > : > Applied research involving polymer interfaces
    > > : > Metallization of plastics
    > > : > Polymer/polymer adhesion
    > > : > Optical coatings
    > > : >
    > > : >
    > > : >
    > > : > 1986-1990 Lord Corporation Cary, NC
    > > : > Senior Research Scientist 1988-1990
    > > : > Research Scientist 1986-1988
    > > : > Basic and applied research on surface chemical bonding
    > > : > Developed new adhesive compositions
    > > : > Developed new sol-gel coatings for corrosion resistance
    > > : >
    > > : >
    > > : > HONORS AND AWARDS
    > > : >
    > > : > Industrial Innovations Award by Northeast Region of American

    Chemical
    > > : Society (6/2001)
    > > : >
    > > : > National Kidney Foundation of Northern California Honoree (5/2001)
    > > : >
    > > : > American Chemical Society/Polymer Chemistry Division Industrial

    > Sponsors
    > > : > Award (8/2000)
    > > : >
    > > : > R&D 100 Award from R&D magazine (1999)
    > > : >
    > > : > Sherwin Williams Award in applied polymer science (9/85)
    > > : >
    > > : > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    > > : >
    > > : > Award for highest GPA in Chemistry Department (6/82)
    > > : >
    > > : > Summa Cum Laude Honors in Chemistry (6/82)
    > > : >
    > > : > Phi Lamda Epsilon (6/82)
    > > : >
    > > : > Phi Beta Kappa (2/82)
    > > : >
    > > : > Cornell University Dean's List (1981, 1982)
    > > : >
    > > : > Harvard Book Club Award for highest GPA senior year (1978)
    > > : >
    > > : > First Place in western NY ACS high school chemistry exam (1977)
    > > : >
    > > : > 1978-1979
    > > : >
    > > : >
    > > : > __________________
    > > : > Randy Holmes-Farley
    > > : > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    > > : >
    > > : > Hobby Experience: 8 years with reefs
    > > : > Current Tanks: 90 gal mixed reef
    > > : > Interests: Reefkeeping, science, photography
    > > : >
    > > : >
    > > : > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    > > : >
    > > : > Open this post in a new window | Report this post to a moderator |

    IP:
    > > : Logged
    > > : >
    > > : >
    > > : >
    > > : > 06/27/2003 02:44 PM
    > > : >
    > > : > Randy Holmes-Farley
    > > : > Chemistry Moderator
    > > : >
    > > : > Registered: Apr 2001
    > > : > Location: Arlington, Massachusetts
    > > : > Occupation: Chemist (Drug Discovery at Genzyme)
    > > : > Posts: 15282
    > > : >
    > > : >
    > > : >
    > > : > Publications
    > > : >
    > > : >
    > > : > ISSUED UNITED STATES PATENTS
    > > : >
    > > : >
    > > : > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;
    > > : Mandeville, III; W. Harry.
    > > : > US 6,566,407; 5/20/2003
    > > : >
    > > : > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen

    > Randall;
    > > : Huval, Chad
    > > : > Cori.
    > > : > U.S. 6,517,825; 2/11/2003.
    > > : >
    > > : > 3. Method of making phosphate-binding polymers for oral

    > administration.
    > > : Holmes-Farley,
    > > : > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.
    > > : 6,509,013; 1/21/2003.
    > > : >
    > > : > 4. Combination therapy for treating hypercholesterolemia using a

    bile
    > acid
    > > : sequestrant
    > > : > polymer
    > > : > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley,

    > Stephen
    > > : Randall;
    > > : > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    > > : >
    > > : > 5. Method for treating hypercholesterolemia with polyallylamine

    > polymers.
    > > : Holmes-Farley,
    > > : > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.;

    > Goldberg,
    > > : Dennis I. , US
    > > : > 6,423,754; 7/23/2002.
    > > : >
    > > : > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry,

    III;
    > > : Neenan, Thomas X..;
    > > : > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    > > : >
    > > : > 7. Combination therapy for treating hypercholesterolemia and
    > > : atherosclerosis. Huval, Chad
    > > : > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal,

    Pradeep
    > K.
    > > : U.S. 6,365,186;
    > > : > 4/2/2002.
    > > : >
    > > : > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.;

    > Mandeville,
    > > : W. H., III;
    > > : > Huval; C.
    > > : > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;
    > > : 10/9/2001.
    > > : >
    > > : > 9. Polymers containing guanidinium groups as bile acid sequestrants.

    > Dhal;
    > > : P. K.; Holmes-
    > > : > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    > > : >
    > > : > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville,

    W.
    > H.,
    > > : III.; US
    > > : > 6,281,252;
    > > : > 8/28/2001.
    > > : >
    > > : > 11. Combination therapy for treating hypercholestrolemia. Huval; C.

    > C.;
    > > : Holmes-Farley; S.
    > > : > R. ;
    > > : > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    > > : >
    > > : > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G.

    M.;
    > > : Holmes-Farley, S.
    > > : > R.; US
    > > : > 6,264,937; 7/24/2001.
    > > : >
    > > : > 13. Method for treating hypercholesterolemia with unsubstituted
    > > : polydiallylamine polymers.
    > > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ;

    US
    > > : 6,248,318;
    > > : > 6/19/2001.
    > > : >
    > > : > 14. Process for removing bile salts from a patient and alkylated
    > > : compositions therefore.
    > > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355;

    5/1/2001.
    > > : >
    > > : > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley,

    S.
    > R.;
    > > : Dhal, P. K.;
    > > : > Petersen,
    > > : > J. S.; US 6,203,785; 3/20/2001.
    > > : >
    > > : > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.;

    > Huval,
    > > : C. C.; US
    > > : > 6,190,649;
    > > : > 2/20/2001.
    > > : >
    > > : > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville,

    W.
    > H.,
    > > : III.; US
    > > : > 6,177,478;
    > > : > 1/23/2001.
    > > : >
    > > : > 18. Water-insoluble noncrosslinked bile acid sequestrants.

    > Holmes-Farley,
    > > : S. R.;
    > > : > Mandeville, W.
    > > : > H., III.; US 6,129,910; 10/10/2000.
    > > : >
    > > : > 19. Method for treating hypercholesterolemia with unsubstituted
    > > : polydiallylamine polymers.
    > > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ;

    US
    > > : 6,083,497;
    > > : > 7/4/2000.
    > > : >
    > > : > 20. Method of making phosphate-binding polymers for oral

    > administration.
    > > : Holmes-Farley, S.
    > > : > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495;

    > 7/4/2000.
    > > : >
    > > : > 21. Process for removing bile salts from a patient and alkylated
    > > : compositions therefore.
    > > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678;

    > 5/23/2000.
    > > : >
    > > : > 22. Process for removing bile salts from a patient and compositions
    > > : therefor. Mandeville,
    > > : > W. H.,
    > > : > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    > > : >
    > > : > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;
    > > : Neenan; T. X.; Holmes-
    > > : > Farley; S. R. US 6,034,129; 3/7/2000.
    > > : >
    > > : > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville,

    W.
    > H.,
    > > : III.; US
    > > : > 5,985,938;
    > > : > 11/16/99.
    > > : >
    > > : > 25. Process for removing bile salts from a patient and compositions
    > > : therefor. Mandeville,
    > > : > W. H.,
    > > : > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    > > : >
    > > : > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville,

    W.
    > H.,
    > > : III.;
    > > : > Holmes-Farley;
    > > : > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    > > : >
    > > : > 27. Hydrophilic nonamine-containing and amine-containing copolymers

    > and
    > > : their use as bile
    > > : > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US

    > 5,929,184;
    > > : 7/27/99.
    > > : >
    > > : > 28. Interpenetrating polymer networks for sequestration of bile

    acids.
    > > : Mandeville, W. H.,
    > > : > III.;
    > > : > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;
    > > : 7/20/99.
    > > : >
    > > : > 29. Amine polymer sequestrant and method of cholesterol depletion.
    > > : Mandeville, W. H.,
    > > : > III.;
    > > : > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    > > : >
    > > : > 30. Process for removing bile salts from a patient and compositions
    > > : therefor. Mandeville,
    > > : > W. H.,
    > > : > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    > > : >
    > > : > 31. Polyamine salt hydrophobic sequestrant for cholesterol

    depletion.
    > > : Mandeville, W. H.,
    > > : > III.;
    > > : > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    > > : >
    > > : > 32. Process for removing bile salts from a patient and compositions
    > > : therefor. Mandeville,
    > > : > W. H.,
    > > : > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    > > : >
    > > : > 33. Preparation of polymeric sequestrants for bile acid salts.

    > Mandeville,
    > > : W. H., III.;
    > > : > Holmes-
    > > : > Farley, S. R.; US 5,703,188; 12/30/97.
    > > : >
    > > : > 34. Oral administration of iron-binding crosslinked amine polymers.
    > > : Mandeville, W. H.,
    > > : > III.;
    > > : > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    > > : >
    > > : > 35. Alkylated amine polymers. Mandeville, W. H., III.;

    Holmes-Farley,
    > S.
    > > : R.; US 5,693,675;
    > > : > 12/2/97.
    > > : >
    > > : > 36. Method for removing bile salts from a patient with alkylated
    > > : crosslinked amine
    > > : > polymers,
    > > : > and preparation of the polymers. Mandeville, W. H., III.;

    > Holmes-Farley,
    > > : S. R.; US
    > > : > 5,679,717; 10/21/97.
    > > : >
    > > : > 37. Phosphate-binding polymers for oral administration.

    Holmes-Farley,
    > S.
    > > : R.; Mandeville,
    > > : > W.
    > > : > H., III.; US 5,667,775; 9/16/97.
    > > : >
    > > : > 38. Ion-exchange process using highly crosslinked polymers for

    > removing
    > > : bile salts from a
    > > : > patient, preparation of the polymers, and compositions containing

    > them.
    > > : Mandeville, W. H.,
    > > : > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    > > : >
    > > : > 39. Hydrophobic amine polymer sequestrant and method of cholesterol
    > > : depletion. Mandeville,
    > > : > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530;

    > 4/8/97.
    > > : >
    > > : > 40. Amine polymer sequestrant and method of cholesterol depletion.
    > > : Mandeville, W. H.,
    > > : > III.;
    > > : > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    > > : >
    > > : > 41. Phosphate-binding polymers for oral administration.

    Holmes-Farley,
    > S.
    > > : R.; Mandeville,
    > > : > W.
    > > : > H., III.; US 5,496,545; 3/5/96.
    > > : >
    > > : > 42. Iron-binding polymers for oral administration. Mandeville, W.

    H.,
    > > : III.; Holmes-Farley,
    > > : > S. R.;
    > > : > US 5,487,888; 1/30/96.
    > > : >
    > > : > 43. Ultra-thin, uniform sol-gel coating of a substrate having active
    > > : hydrogens on the
    > > : > surface.
    > > : > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    > > : >
    > > : > 44. Layered sol-gel coatings from organisilicon compounds.

    > Holmes-Farley,
    > > : S. R.; Yanyo, L.
    > > : > C.;
    > > : > US 5,182,143; 1/26/93.
    > > : >
    > > : > 45. Method for metal bonding using ultrathin primer coating.
    > > : Holmes-Farley, S. R.; Yanyo,
    > > : > L.
    > > : > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    > > : >
    > > : > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K.

    J.;
    > US
    > > : 5,096,962;
    > > : > 3/17/92.
    > > : >
    > > : > 47. Modified halogenatedpolyolefin adhesives for polyolefin
    > > : elastomer-metal bonding.
    > > : > Holmes-
    > > : > Farley, S. R.; US 5,102,956; 4/7/92.
    > > : >
    > > : >
    > > : >
    > > : > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    > > : >
    > > : >
    > > : > 1. Aryl boronate functionalized polymers for treating obesity and
    > > : inhibiting fat uptake.
    > > : > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal,

    > Pradeep
    > > : K.; Huval, Chad
    > > : > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92

    > pp. WO
    > > : 0302571.
    > > : >
    > > : > 2. Preparation of aryl boronic acids for treating obesity.

    > Holmes-Farley,
    > > : Stephen Randall;
    > > : > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal,

    Pradeep
    > K.
    > > : (Geltex
    > > : > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO

    0302570.
    > > : >
    > > : > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,
    > > : Stephen Randall.
    > > : > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp.

    WO
    > > : 0302130.
    > > : >
    > > : > 4. Method for reducing copper levels and treating copper toxicosis.
    > > : Holmes-Farley, Stephen
    > > : > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002),

    > 45
    > > : pp. WO
    > > : > 0285383.
    > > : >
    > > : > 5. Method for treating gout and binding uric acid. Holmes-Farley,

    > Stephen
    > > : Randall; Burke,
    > > : > Steven K. WO 0285381 10/31/2002.
    > > : >
    > > : > 6. Method for treating gout and reducing serum uric acid.

    > Holmes-Farley,
    > > : Stephen Randall;
    > > : > Burke, Steven K WO 0285380 10/31/2002.
    > > : >
    > > : > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;
    > > : Holmes-Farley, S. R.;
    > > : > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    > > : >
    > > : > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III

    and
    > > : Holmes-Farley, S.
    > > : > R.;
    > > : > WO 1999-US5662; 9/23/1999.
    > > : >
    > > : > 9. Amine-containing copolymers as bile acid sequestrants.

    > Holmes-Farley,
    > > : S. R.; Petersen,
    > > : > J. S.;
    > > : > WO 9933452; 7/8/1999.
    > > : >
    > > : > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III

    > and
    > > : Holmes-Farley, S.
    > > : > R.;
    > > : > WO 9922743; 5/14/1999.
    > > : >
    > > : > 11. Polyallylamine polymers for removing bile salts and treating
    > > : hypercholesterolemia, and
    > > : > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III;

    > Burke,
    > > : S. K.; Goldberg,
    > > : > D. I.; WO 9857652; 12/23/98.
    > > : >
    > > : > 12. Phosphate-bidning polymers combined with a calcium supplement

    for
    > oral
    > > : administration.
    > > : > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III;

    Holmes-Farley,
    > S.
    > > : R.; WO 9842355;
    > > : > 10/1/98.
    > > : >
    > > : > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol
    > > : depletion. Mandeville,
    > > : > W.
    > > : > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449;

    12/12/96.
    > > : >
    > > : > 14. Process for adjusting ion concentration in a patient and

    > compositions
    > > : therefor.
    > > : > Mandeville,
    > > : > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    > > : >
    > > : > 15. Vacuum-deposited silver on polycarbonate with a chromium

    > interlayer
    > > : for improved
    > > : > metal-
    > > : > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512;

    > 1/20/94.
    > > : >
    > > : > 16. Process for increased metal-substrate bond strength in metalized
    > > : plastics.
    > > : > Holmes-Farley, S.
    > > : > R.; Ger. Offen. 4322516; 7/6/93.
    > > : >
    > > : > 17. Electrorheological fluids and preparation of particles useful in

    > the
    > > : fluids.
    > > : > Troughton,
    > > : > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.
    > > : David; Bares, Joseph
    > > : > E.;
    > > : > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell.

    EP
    > > : 394049;
    > > : > 10/24/1990.
    > > : >
    > > : > JOURNAL PUBLICATIONS
    > > : >
    > > : > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov,

    > Eugene;
    > > : Guo, Amy;
    > > : > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;
    > > : Mandeville, W. Harry;
    > > : > Holmes-Farley, S. Randall. Kidney International (2002), 62(2),

    > 611-619.
    > > : >
    > > : > 2. Amine functionalized polyethers as bile acid sequestrants:

    > synthesis
    > > : and biological
    > > : > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S.

    > Randall;
    > > : Mandeville, W.
    > > : > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.
    > > : Journal of
    > > : > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),
    > > : 1559-1574.
    > > : >
    > > : > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular
    > > : Imprinting. Huval,
    > > : > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.
    > > : Randall; Mandeville,
    > > : > W.
    > > : > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert

    > J.;
    > > : Chen, Xi; Dhal,
    > > : > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    > > : >
    > > : > 4. Synthetic polymers for the binding of fat in the intestinal

    tract.
    > > : Jozefiak, Thomas H.;
    > > : > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia;

    > Huval,
    > > : Chad C.;
    > > : > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.
    > > : Abstracts of
    > > : > Papers, 222nd ACS National Meeting, Chicago, IL, United States,

    August
    > > : 26-30, 2001
    > > : > (2001), POLY-047 and Polymer Preprints (American Chemical Society,
    > > : Division of
    > > : > Polymer Chemistry) (2001), 42(2), 98.
    > > : >
    > > : > 5. Colesevelam hydrochloride: Synthesis and testing of a novel

    polymer
    > gel
    > > : pharmaceutical.
    > > : > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.;

    > Ward,
    > > : J.; Sacchiero,
    > > : > B.;
    > > : > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.;

    > Chen,
    > > : X.; Mazzeo, J.
    > > : > R.. Polym. Preprints (2000), 41(1), 735-736.
    > > : >
    > > : > 6. In vitro comparison of bile acid binding to colesevelam HCl and

    > other
    > > : bile acid
    > > : > sequestrants.
    > > : > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu,

    Q.;
    > > : Hook, P.; Holmes-
    > > : > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1),

    708-709.
    > > : >
    > > : > 7. Novel polymeric pharmaceuticals: From startup to market.

    > Holmes-Farley,
    > > : S. R; Polym.
    > > : > Mater. Sci. Eng (1999), 80, 246-247.
    > > : >
    > > : > 8. Design and characterization of of Sevelamer Hydrochloride: a

    novel
    > > : phosphate-binding
    > > : > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward,

    > J.;
    > > : Miller, K. L.;
    > > : > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pur

    e
    > and
    > > : Appl. Chem.,
    > > : > A36(7&8), p. 1085 (1999).
    > > : >
    > > : > 9. Three generations of bile acid sequestrants. Mandeville, W. H.,

    > III;
    > > : Braunlin, W.;
    > > : > Dhal, P.;
    > > : > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;
    > > : Rosenbaum, D.;
    > > : > Sacchiero,
    > > : > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc.

    (1999),
    > > : 550, 3-15.
    > > : >
    > > : > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric

    > phosphate
    > > : binder, on
    > > : > urinary
    > > : > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S.

    R.;
    > > : Mandeville, W. H.,
    > > : > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial.,

    Transplant.
    > > : (1997), 12(5)
    > > : > 961-964.
    > > : >
    > > : > 11. Thin anisotropic coatings based on sol-gel technology.

    > Holmes-Farley,
    > > : S. R.; Yanyo, L.
    > > : > C;
    > > : > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4),

    > 439-444.
    > > : >
    > > : > 12. The mechanism of cure initiation of a surface activated

    adhesive.
    > > : Holmes-Farley, S.
    > > : > R.;
    > > : > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    > > : >
    > > : > 13. Adhesion promotion and corrosion prevention using thin

    anisotropic
    > > : coatings. Holmes-
    > > : > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),
    > > : 131-151.
    > > : >
    > > : > 14. Wetting of functionalized polyethylene having ionizable organic

    > acids
    > > : and bases at the
    > > : > polymer-water interface: relations between functional group

    polarity,
    > > : extent of
    > > : > ionization,
    > > : > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;
    > > : Whitesides, G. M.;
    > > : > Langmuir
    > > : > (1988), 4(4), 921-937.
    > > : >
    > > : > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a
    > > : single hydroxy group.
    > > : > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    > > : >
    > > : > 16. Reconstruction of the interface of oxidatively functionalized
    > > : polyethylene (PE-CO2H)
    > > : > and
    > > : > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo,

    > R.;
    > > : McCarthy, T. J.;
    > > : > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report

    > (1987),
    > > : AD-
    > > : > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    > > : >
    > > : > 17. Surface-modified polyethylene film: the relationship between

    > surface
    > > : chemistry and
    > > : > physical
    > > : > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11),

    > 4537.
    > > : >
    > > : > 18. Reactivity of carboxylic acid and ester groups in the

    > functionalized
    > > : interfacial
    > > : > region of
    > > : > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:
    > > : differentiation of the
    > > : > functional groups into shallow and deep subsets based on a

    comparison
    > of
    > > : contact angle and
    > > : > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.;

    Langmuir
    > > : (1987), 3(1), 62-
    > > : > 76.
    > > : >
    > > : > 19. Fluorescence properties of dansyl groups covalently bonded tot

    he
    > > : surface of
    > > : > oxidatively
    > > : > functionalized low-density polyethylene film. Holmes-Farley, S. R.;
    > > : Whitesides, G. M.;
    > > : > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;
    > > : AD-A162435/2/GAR,
    > > : > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    > > : >
    > > : > 20. Acid-base behavior of carboxylic acid groups covalently attached

    > at
    > > : the surface of
    > > : > polyethylene: The usefulness of contact angle in following the

    > ionization
    > > : of surface
    > > : > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;
    > > : Deutch, J.;
    > > : > Whitesides,
    > > : > G. M.; Langmuir (1985), 1(6), 725-740.
    > > : >
    > > : > 21. The thermal stability of a surface modified solid organic

    polymer.
    > > : Holmes-Farley, S.
    > > : > R.;
    > > : > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    > > : >
    > > : >
    > > : >
    > > : > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    > > : >
    > > : > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R.

    Advanced
    > > : Aquarist. June 2003.
    > > : >
    > > : > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley,

    R.
    > > : Advanced Aquarist.
    > > : > May
    > > : > 2003.
    > > : >
    > > : > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley,

    R.
    > > : Reefkeeping May
    > > : > 2003.
    > > : >
    > > : > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R.

    Reefkeeping
    > > : April 2003.
    > > : >
    > > : > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > > : Holmes-Farley, R.
    > > : > Advanced Aquarist; April 2003.
    > > : >
    > > : > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > > : Holmes-Farley, R.
    > > : > Advanced Aquarist; April 2003.
    > > : >
    > > : > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced

    > Aquarist;
    > > : March 2003.
    > > : >
    > > : > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.
    > > : Holmes-Farley, R.
    > > : > Advanced Aquarist; February 2003.
    > > : >
    > > : > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist;

    January
    > > : 2003.
    > > : >
    > > : > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist;

    > December
    > > : 2002.
    > > : >
    > > : > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R.

    > Advanced
    > > : Aquarist; November
    > > : > 2002.
    > > : >
    > > : > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley,

    R.
    > > : Advanced Aquarist;
    > > : > November 2002.
    > > : >
    > > : > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced

    > Aquarist,
    > > : September 2002.
    > > : >
    > > : > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist,

    August
    > > : 2002.
    > > : >
    > > : > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com,

    April
    > > : 2002.
    > > : >
    > > : > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced
    > > : Aquarist; July 2002
    > > : >
    > > : > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist;

    > June
    > > : 2002.
    > > : >
    > > : > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R.

    > Advanced
    > > : Aquarist, May
    > > : > 2002.
    > > : >
    > > : > 19. The Chemical & Biochemical Mechanisms of Calcification in

    Corals.
    > > : Holmes-Farley, R.
    > > : > Advanced Aquarist, April 2002.
    > > : >
    > > : > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    > > : >
    > > : > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    > > : >
    > > : > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January

    > 2002.
    > > : >
    > > : > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium

    Frontiers
    > > : 2000.
    > > : >
    > > : > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium
    > > : Frontiers 2000.
    > > : >
    > > : > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.
    > > : Aquarium Frontiers
    > > : > 2000.
    > > : > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium

    > Frontiers
    > > : 2000.
    > > : >
    > > : > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers

    > 2000.
    > > : >
    > > : > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers

    1999.
    > > : >
    > > : > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    > > : >
    > > : >
    > > : >
    > > : >
    > > : >
    > > : >
    > > : >
    > > : > Boomer
    > > : >
    > > : > Want to talk chemistry ? The Reef Chemistry Forum
    > > : > http://www.reefcentral.com/vbulletin/index.php
    > > : >
    > > : > Want to See More ?
    > > : > Please Join Our Growing Membership
    > > : > www.coralrealm.com
    > > : >
    > > : >
    > > : >
    > > :
    > > :
    > >
    > >

    >
    >
     
    stoutman, Feb 11, 2004
    #57
  18. Dinky

    stoutman Guest

    I have a suspicion that you are dragging this out and debating me because
    you don't want to admit you are wrong in front of everyone else. I have
    NOTHING to prove. I have never written in this newsgroup until very
    recently. Based on some of the comments others have made, I suspect that
    you are a long time contributor to this NG and to some aquarium forum and
    you feel you have a reputation to uphold. I am almost 100% sure you know
    you are wrong with respect to our disagreements and you just want to keep
    fighting me hoping I make a mistake. You have made SEVERAL mistakes and
    contradictions. Even cited web pages that contradict yourself.

    If you are unsure were you have contradicted yourself, I will take the time
    to show you.

    I am truly sorry that I soiled your GURU reputation. I can only suggest you
    read some general CHEMISTRY books. I bet you would enjoy and benefit from
    them. You seem to have an interest in chem. and aquariums. Most aquarium
    enthusiasts don't care what's going on at a chemical level, they just dump A
    into their tank and measure X. You do, and I'm glad for you. Feed your
    chemical knowledge by getting the basics down and then build. Your
    chemistry knowledge you have learned thus far is on a VERY shaky foundation.
    This can be corrected.

    Take care,
    -Stoutman



    "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    news:102kn4e6f2vvb1@corp.supernews.com...
    > Alkalinity a measure of the amount of anions of weak acid in water and of

    the cations
    > balanced against them
    > Take note it says ***acid***
    >
    > Buffering capacity the ability of a solution to resist or dampen changes

    in pH upon the
    > addition of acids or bases.
    > Take note its says ***the addition of acids or bases***
    >
    > One more
    >
    > http://www.waterontheweb.org/resources/glossary.html
    >
    > We could go on like this all day, so what is the point ?
    >
    > You will LOVE this one
    > http://www.kyantec.com/Tips/phbuffering.htm
    >
    > Don't you just lovbe PDF's
    > http://www.inform.umd.edu/manurenet/reprints/98.1702.pdf
    >
    > Don't fall out of your chair
    > http://www.chemforlife.org/teacher/topics/chemistry_in_an_aquarium.htm
    >
    >
    >
    >
    > --
    > Boomer
    >
    > Want to talk chemistry ? The Reef Chemistry Forum
    > http://www.reefcentral.com/vbulletin/index.php
    >
    > Want to See More ?
    > Please Join Our Growing Membership
    > www.coralrealm.com
    >
    > If You See Me Running You Better Catch-Up
    > "stoutman" <.@.> wrote in message news:XB7Wb.19339$QA2.62332@attbi_s52...
    > : Man here is another, google is a wonderful thing. I'm not filtering any
    > : out, just posting what I find by GOOGLING for you.
    > :
    > : http://www.globe.gov/hq/trr_suppl/hydro/HY_SUP_ALK_INTRO_NOTES.HTML
    > :
    > :
    > : Wow, a gov link. Even the government is wrong, this must be a

    conspiracy
    > : against Boomer.
    > :
    > :
    > :
    > :
    > : "Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    > : news:102ht0bjplpo059@corp.supernews.com...
    > : > Now I am getting bored
    > : >
    > : > "Don't the components of a buffer account for the buffering capacity?
    > : Yes."
    > : >
    > : > Yes, agreed but you seem to fail what I'm saying. Buffering Capacity

    and
    > : Alkalinity are
    > : > not the same, that has always been the issue. I gave the equation does
    > : that look like an
    > : > Alkalinity equation or how Alk is determined. I see you had now

    comments
    > : on it what's
    > : > wrong, why no comments on the equations I gave. Don't understand them

    or
    > : what ? Again this
    > : > is the equation for Buffering Capacity, also called Buffer Index or

    Buffer
    > : Intensity. It
    > : > is defined in most water chemistry and chemical oceanography text

    books.
    > : >
    > : > B (Buffering Capacity) = dCb / dpH = 2.303 ( Kw/[H30+] + [H30+] +

    CKa
    > : [H3O+] / (Ka =
    > : > H3O+])² )
    > : >
    > : > This is not Alkalinity now is it ?
    > : >
    > : > "I know how to do a titration, In fact I have done several. How many

    have
    > : > you actually done? I don't mean by counting drops, I mean with a

    buret?"
    > : >
    > : > Well good for you, I use a Digital Titrator
    > : >
    > : > "Oh, I see,
    > : > you think acidity is the opposite of alkalinity. In the world of
    > : CHEMISTRY
    > : > it's not. Maybe in aquarium newsgroups it is.
    > : >
    > : > Hum no, maybe you should go for a look at HACH's or LaMotte website or

    the
    > : book I
    > : > suggested earlier. Please view a copy.
    > : >
    > : > Standard Methods for the Examination of Water and Wastewater
    > : >
    > : > This book, over 2000 pages, is the guide for water testing. If you are
    > : reporting water
    > : > test to the EPA you must use approved std from this text.I t is

    prepared
    > : and published by
    > : > the EPA, American Water Works Association and American Public Health
    > : Association. You
    > : > mean you don't have one and the issue is water chemistry
    > : >
    > : > You are confusing Acidity and Acidity as you know little about water
    > : chemistry and
    > : > procedures and test methods
    > : >
    > : > From SMEWW, section 2-30, 2310 ACIDITY
    > : >
    > : > "Acidity of water is its quantative capacity to react with a strong

    base
    > : to a designated
    > : > pH"
    > : >
    > : > This is how you test for it
    > : >
    > : > A std alkali titration to methyl orange or phenolphthalein
    > : > endpoint.
    > : >
    > : > BUT YOU SAID THIS IS WRONG. Please tell all the chemist that write

    this
    > : book, there are
    > : > over 100 of them, they are wrong.
    > : >
    > : > Like Buffering Capacity you have your Acidity's mixed up
    > : > In water measurement if you have a high Alk you also usually have a

    high
    > : Acidity.
    > : > Normally a high Alk also gives a higher CO2 level. Get a WATER

    CHEMISTRY
    > : BOOK there pal.
    > : >
    > : >
    > : > "These are all in equilibrium with each other. An initial high pH

    (above
    > : > 6.4) will shift the equilibrium to the right to form HCO3-1. If the

    pH of
    > : > the solution is above 10.3 (pKa2) the .........."
    > : >
    > : >
    > : > Christ, there you go again with the FW shit. All your numbers are

    wrong we
    > : are dealing
    > : > with SEAWATER
    > : >
    > : > This means that at a pH of 8.3, the majority of the CO2(aq) is in the

    form
    > : > of HCO3-1 .
    > : >
    > : > I have already pointed that out and gave actual values at know

    seawater
    > : levels, go back
    > : > and re-read it you aren't telling me anything here.Of course most is

    HCO3
    > : see...
    > : >
    > : >
    > : > @ 20C and 34.3 ppt salinity
    > : >
    > : > CO2 = 0.52 %
    > : >
    > : > HCO3 = 86.4 %
    > : >
    > : > CO3 = 13.09 %
    > : >
    > : >
    > : > "In your glass experiment you managed to lower the pH enough to purge

    out
    > : CO2
    > : > by boiling"
    > : >
    > : > The purpose behind the glass is to show that alk is not affect by CO2

    and
    > : vise-versa and
    > : > how Co2 affects pH.
    > : >
    > : > Now, in a real life seawater aquarium, with a pH of 8.3 and that pH

    drops
    > : to say 8.1 it is
    > : > usually due to excess CO2. If you took a glass of that water and

    aerated
    > : it you WILL drive
    > : > off the CO2 and raise the pH. It has been done a proven a million

    times.
    > : >
    > : > "In order to 'purge' CO2 you would need to lower the
    > : > pH to shift the equilibrium to below 6.4"
    > : >
    > : > The hell you do !!!.Do you know who many times people on this NG to
    > : include Dr. Craig
    > : > Bingman a chemist and Dr. Randy Holmes-Farley have mentioned to take a
    > : sample of aquarium
    > : > water and aerate it to see if the pH GOES UP AND when they come back

    with
    > : the test it is
    > : > often YES the pH went back up. PROBLEM THERE MISTER PH.D CHEMIST

    excess
    > : CO2 in the tank
    > : > water, increase the circulation for better gas exchange at the

    surface,
    > : reduce feeding,
    > : > and try to improve on better skimming, thus reducing the bio-load and

    pH
    > : decline due to
    > : > CO2.
    > : >
    > : >
    > : > "I hope this helps. "
    > : >
    > : > Help, how can you when you miss everything. I should be charging you
    > : >
    > : > Oh, by the way. Your websites, I have about 50 on these issues, I

    could
    > : post them, not to
    > : > mention I have all those water chemistry books, so there is no need to
    > : view your sites.
    > : >
    > : > Finally are you afraid to come to our Chemistry Forum, afraid to get
    > : slapped by REAL
    > : > chemists. I get a charge out of you can't post your ref .I have posted

    the
    > : same or similar
    > : > stuff on his forum and I wasn't pointed out WRONG pal. I have 1500

    posts
    > : there and am the
    > : > biggest contributor to his forum other than himself or maybe Habib

    Sheka
    > : >
    > : > Hum, here are Randy's ref that he posted. He hosts the website
    > : >
    > : > S. RANDY HOLMES-FARLEY
    > : > Arlington, Massachusetts
    > : >
    > : > EDUCATION
    > : >
    > : > 1982-1986 Harvard University Cambridge, MA
    > : > PhD in Chemistry
    > : > Research Advisor: George Whitesides
    > : >
    > : > Investigated the relationship between polymer surface chemistry and
    > : physical properties
    > : > through controlled surface modification and testing.
    > : >
    > : > 1980-1982 Cornell University Ithaca, NY
    > : > BA in Chemistry and Biology
    > : > Graduated Summa Cum Laude
    > : > Distinction in All Subjects
    > : > Grade Point: 3.94/4.0
    > : > Honors research: isolation and characterization of the subunit of CF1
    > : enzyme
    > : >
    > : >
    > : > 1978-1979 Stanford University Palo Alto, CA
    > : > Grade Point: 3.55/4.0
    > : >
    > : >
    > : > EXPERIENCE
    > : >
    > : > 1992- present Genzyme Drug Disvcovery and Development Waltham, MA
    > : > (bought out GelTex Pharmaceuticals in 2001)
    > : > Vice President, Chemical Research 2001-present
    > : > Senior Director, Chemical Research 1999-2001
    > : > Director of Chemical Research 1997-1999
    > : > Manager of Chemical Research 1995-1997
    > : > Group Leader 1994-1995
    > : > Senior Research Scientist 1992-1994
    > : >
    > : > Helped start GelTex as second employee
    > : >
    > : > Managed various research programs with multi-million dollar budgets
    > : >
    > : > Supervised research chemists (17+)
    > : >
    > : > Co-inventor of several polymeric pharmaceuticals and pharmaceutical
    > : candidates including
    > : > Sevelamer Hydrochloride (FDA approved) and Colesevelam Hydrochloride

    (FDA
    > : approved)
    > : >
    > : > Company Safety Officer for 3 years
    > : >
    > : > Chemical Hygiene Officer 2000-present
    > : >
    > : >
    > : >
    > : >
    > : > 1990-1992 GTE Corporation Waltham, MA
    > : > Senior Member of Technical Staff
    > : > Applied research involving polymer interfaces
    > : > Metallization of plastics
    > : > Polymer/polymer adhesion
    > : > Optical coatings
    > : >
    > : >
    > : >
    > : > 1986-1990 Lord Corporation Cary, NC
    > : > Senior Research Scientist 1988-1990
    > : > Research Scientist 1986-1988
    > : > Basic and applied research on surface chemical bonding
    > : > Developed new adhesive compositions
    > : > Developed new sol-gel coatings for corrosion resistance
    > : >
    > : >
    > : > HONORS AND AWARDS
    > : >
    > : > Industrial Innovations Award by Northeast Region of American Chemical
    > : Society (6/2001)
    > : >
    > : > National Kidney Foundation of Northern California Honoree (5/2001)
    > : >
    > : > American Chemical Society/Polymer Chemistry Division Industrial

    Sponsors
    > : > Award (8/2000)
    > : >
    > : > R&D 100 Award from R&D magazine (1999)
    > : >
    > : > Sherwin Williams Award in applied polymer science (9/85)
    > : >
    > : > IBM Predoctoral Fellowship in Polymer Science (1984-1985; 1985-1986)
    > : >
    > : > Award for highest GPA in Chemistry Department (6/82)
    > : >
    > : > Summa Cum Laude Honors in Chemistry (6/82)
    > : >
    > : > Phi Lamda Epsilon (6/82)
    > : >
    > : > Phi Beta Kappa (2/82)
    > : >
    > : > Cornell University Dean's List (1981, 1982)
    > : >
    > : > Harvard Book Club Award for highest GPA senior year (1978)
    > : >
    > : > First Place in western NY ACS high school chemistry exam (1977)
    > : >
    > : > 1978-1979
    > : >
    > : >
    > : > __________________
    > : > Randy Holmes-Farley
    > : > Want to talk chemistry? Try the Reef Chemistry Forum at Reef Central
    > : >
    > : > Hobby Experience: 8 years with reefs
    > : > Current Tanks: 90 gal mixed reef
    > : > Interests: Reefkeeping, science, photography
    > : >
    > : >
    > : > Last edited by Randy Holmes-Farley on 10/01/2003 at 07:49 PM
    > : >
    > : > Open this post in a new window | Report this post to a moderator | IP:
    > : Logged
    > : >
    > : >
    > : >
    > : > 06/27/2003 02:44 PM
    > : >
    > : > Randy Holmes-Farley
    > : > Chemistry Moderator
    > : >
    > : > Registered: Apr 2001
    > : > Location: Arlington, Massachusetts
    > : > Occupation: Chemist (Drug Discovery at Genzyme)
    > : > Posts: 15282
    > : >
    > : >
    > : >
    > : > Publications
    > : >
    > : >
    > : > ISSUED UNITED STATES PATENTS
    > : >
    > : >
    > : > 1. Method for reducing oxalate. Holmes-Farley, Stephen Randall;
    > : Mandeville, III; W. Harry.
    > : > US 6,566,407; 5/20/2003
    > : >
    > : > 2. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen

    Randall;
    > : Huval, Chad
    > : > Cori.
    > : > U.S. 6,517,825; 2/11/2003.
    > : >
    > : > 3. Method of making phosphate-binding polymers for oral

    administration.
    > : Holmes-Farley,
    > : > Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S.
    > : 6,509,013; 1/21/2003.
    > : >
    > : > 4. Combination therapy for treating hypercholesterolemia using a bile

    acid
    > : sequestrant
    > : > polymer
    > : > and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley,

    Stephen
    > : Randall;
    > : > Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.
    > : >
    > : > 5. Method for treating hypercholesterolemia with polyallylamine

    polymers.
    > : Holmes-Farley,
    > : > Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.;

    Goldberg,
    > : Dennis I. , US
    > : > 6,423,754; 7/23/2002.
    > : >
    > : > 6. Ionic polymers as anti-infective agents Mandeville, W. Harry, III;
    > : Neenan, Thomas X..;
    > : > Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.
    > : >
    > : > 7. Combination therapy for treating hypercholesterolemia and
    > : atherosclerosis. Huval, Chad
    > : > Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep

    K.
    > : U.S. 6,365,186;
    > : > 4/2/2002.
    > : >
    > : > 8. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.;

    Mandeville,
    > : W. H., III;
    > : > Huval; C.
    > : > C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868;
    > : 10/9/2001.
    > : >
    > : > 9. Polymers containing guanidinium groups as bile acid sequestrants.

    Dhal;
    > : P. K.; Holmes-
    > : > Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001
    > : >
    > : > 10. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 6,281,252;
    > : > 8/28/2001.
    > : >
    > : > 11. Combination therapy for treating hypercholestrolemia. Huval; C.

    C.;
    > : Holmes-Farley; S.
    > : > R. ;
    > : > Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.
    > : >
    > : > 12. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.;
    > : Holmes-Farley, S.
    > : > R.; US
    > : > 6,264,937; 7/24/2001.
    > : >
    > : > 13. Method for treating hypercholesterolemia with unsubstituted
    > : polydiallylamine polymers.
    > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    > : 6,248,318;
    > : > 6/19/2001.
    > : >
    > : > 14. Process for removing bile salts from a patient and alkylated
    > : compositions therefore.
    > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.
    > : >
    > : > 15. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S.

    R.;
    > : Dhal, P. K.;
    > : > Petersen,
    > : > J. S.; US 6,203,785; 3/20/2001.
    > : >
    > : > 16. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.;

    Huval,
    > : C. C.; US
    > : > 6,190,649;
    > : > 2/20/2001.
    > : >
    > : > 17. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 6,177,478;
    > : > 1/23/2001.
    > : >
    > : > 18. Water-insoluble noncrosslinked bile acid sequestrants.

    Holmes-Farley,
    > : S. R.;
    > : > Mandeville, W.
    > : > H., III.; US 6,129,910; 10/10/2000.
    > : >
    > : > 19. Method for treating hypercholesterolemia with unsubstituted
    > : polydiallylamine polymers.
    > : > Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US
    > : 6,083,497;
    > : > 7/4/2000.
    > : >
    > : > 20. Method of making phosphate-binding polymers for oral

    administration.
    > : Holmes-Farley, S.
    > : > R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495;

    7/4/2000.
    > : >
    > : > 21. Process for removing bile salts from a patient and alkylated
    > : compositions therefore.
    > : > Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678;

    5/23/2000.
    > : >
    > : > 22. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.
    > : >
    > : > 23. Ionic polymers as anti-infective agents. Mandeville, III; W. H;
    > : Neenan; T. X.; Holmes-
    > : > Farley; S. R. US 6,034,129; 3/7/2000.
    > : >
    > : > 24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W.

    H.,
    > : III.; US
    > : > 5,985,938;
    > : > 11/16/99.
    > : >
    > : > 25. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.
    > : >
    > : > 26. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W.

    H.,
    > : III.;
    > : > Holmes-Farley;
    > : > S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.
    > : >
    > : > 27. Hydrophilic nonamine-containing and amine-containing copolymers

    and
    > : their use as bile
    > : > acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US

    5,929,184;
    > : 7/27/99.
    > : >
    > : > 28. Interpenetrating polymer networks for sequestration of bile acids.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379;
    > : 7/20/99.
    > : >
    > : > 29. Amine polymer sequestrant and method of cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,919,832; 7/6/99.
    > : >
    > : > 30. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.
    > : >
    > : > 31. Polyamine salt hydrophobic sequestrant for cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.
    > : >
    > : > 32. Process for removing bile salts from a patient and compositions
    > : therefor. Mandeville,
    > : > W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.
    > : >
    > : > 33. Preparation of polymeric sequestrants for bile acid salts.

    Mandeville,
    > : W. H., III.;
    > : > Holmes-
    > : > Farley, S. R.; US 5,703,188; 12/30/97.
    > : >
    > : > 34. Oral administration of iron-binding crosslinked amine polymers.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,702,696; 12/30/97.
    > : >
    > : > 35. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley,

    S.
    > : R.; US 5,693,675;
    > : > 12/2/97.
    > : >
    > : > 36. Method for removing bile salts from a patient with alkylated
    > : crosslinked amine
    > : > polymers,
    > : > and preparation of the polymers. Mandeville, W. H., III.;

    Holmes-Farley,
    > : S. R.; US
    > : > 5,679,717; 10/21/97.
    > : >
    > : > 37. Phosphate-binding polymers for oral administration. Holmes-Farley,

    S.
    > : R.; Mandeville,
    > : > W.
    > : > H., III.; US 5,667,775; 9/16/97.
    > : >
    > : > 38. Ion-exchange process using highly crosslinked polymers for

    removing
    > : bile salts from a
    > : > patient, preparation of the polymers, and compositions containing

    them.
    > : Mandeville, W. H.,
    > : > III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.
    > : >
    > : > 39. Hydrophobic amine polymer sequestrant and method of cholesterol
    > : depletion. Mandeville,
    > : > W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530;

    4/8/97.
    > : >
    > : > 40. Amine polymer sequestrant and method of cholesterol depletion.
    > : Mandeville, W. H.,
    > : > III.;
    > : > Holmes-Farley, S. R.; US 5,607,669; 3/4/97.
    > : >
    > : > 41. Phosphate-binding polymers for oral administration. Holmes-Farley,

    S.
    > : R.; Mandeville,
    > : > W.
    > : > H., III.; US 5,496,545; 3/5/96.
    > : >
    > : > 42. Iron-binding polymers for oral administration. Mandeville, W. H.,
    > : III.; Holmes-Farley,
    > : > S. R.;
    > : > US 5,487,888; 1/30/96.
    > : >
    > : > 43. Ultra-thin, uniform sol-gel coating of a substrate having active
    > : hydrogens on the
    > : > surface.
    > : > Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.
    > : >
    > : > 44. Layered sol-gel coatings from organisilicon compounds.

    Holmes-Farley,
    > : S. R.; Yanyo, L.
    > : > C.;
    > : > US 5,182,143; 1/26/93.
    > : >
    > : > 45. Method for metal bonding using ultrathin primer coating.
    > : Holmes-Farley, S. R.; Yanyo,
    > : > L.
    > : > C.; Thuer, A. M.; US 5,139,601; 8/18/92.
    > : >
    > : > 46. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.;

    US
    > : 5,096,962;
    > : > 3/17/92.
    > : >
    > : > 47. Modified halogenatedpolyolefin adhesives for polyolefin
    > : elastomer-metal bonding.
    > : > Holmes-
    > : > Farley, S. R.; US 5,102,956; 4/7/92.
    > : >
    > : >
    > : >
    > : > PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)
    > : >
    > : >
    > : > 1. Aryl boronate functionalized polymers for treating obesity and
    > : inhibiting fat uptake.
    > : > Holmes-Farley, Stephen Randall; Mandeville, Harry W., III; Dhal,

    Pradeep
    > : K.; Huval, Chad
    > : > Cori; Li, Xinhua; Polomoscanik, Steven C. PCT Int. Appl. (2003), 92

    pp. WO
    > : 0302571.
    > : >
    > : > 2. Preparation of aryl boronic acids for treating obesity.

    Holmes-Farley,
    > : Stephen Randall;
    > : > Mandeville, W. Harry, III; Huval, Chad Cori; Li, Xinhua; Dhal, Pradeep

    K.
    > : (Geltex
    > : > Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 62 pp. WO 0302570.
    > : >
    > : > 3. Fat-binding poly(diethanolaminopropyl)acrylamide. Holmes-Farley,
    > : Stephen Randall.
    > : > (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2003), 32 pp. WO
    > : 0302130.
    > : >
    > : > 4. Method for reducing copper levels and treating copper toxicosis.
    > : Holmes-Farley, Stephen
    > : > Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002),

    45
    > : pp. WO
    > : > 0285383.
    > : >
    > : > 5. Method for treating gout and binding uric acid. Holmes-Farley,

    Stephen
    > : Randall; Burke,
    > : > Steven K. WO 0285381 10/31/2002.
    > : >
    > : > 6. Method for treating gout and reducing serum uric acid.

    Holmes-Farley,
    > : Stephen Randall;
    > : > Burke, Steven K WO 0285380 10/31/2002.
    > : >
    > : > 7. Amine condensation polymer bile acid sequestrants. Huval, C. C.;
    > : Holmes-Farley, S. R.;
    > : > Whitesides, G. M. WO 1999-US30469; 7/6/2000.
    > : >
    > : > 8. Continuous crosslinking of polymer gels. Mandeville, W. H., III and
    > : Holmes-Farley, S.
    > : > R.;
    > : > WO 1999-US5662; 9/23/1999.
    > : >
    > : > 9. Amine-containing copolymers as bile acid sequestrants.

    Holmes-Farley,
    > : S. R.; Petersen,
    > : > J. S.;
    > : > WO 9933452; 7/8/1999.
    > : >
    > : > 10. Polydiallylamine-based phosphate binders. Mandeville, W. H., III

    and
    > : Holmes-Farley, S.
    > : > R.;
    > : > WO 9922743; 5/14/1999.
    > : >
    > : > 11. Polyallylamine polymers for removing bile salts and treating
    > : hypercholesterolemia, and
    > : > polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III;

    Burke,
    > : S. K.; Goldberg,
    > : > D. I.; WO 9857652; 12/23/98.
    > : >
    > : > 12. Phosphate-bidning polymers combined with a calcium supplement for

    oral
    > : administration.
    > : > Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley,

    S.
    > : R.; WO 9842355;
    > : > 10/1/98.
    > : >
    > : > 13. Hydrophobic heteroatom-containing sequestrant for cholesterol
    > : depletion. Mandeville,
    > : > W.
    > : > H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.
    > : >
    > : > 14. Process for adjusting ion concentration in a patient and

    compositions
    > : therefor.
    > : > Mandeville,
    > : > W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.
    > : >
    > : > 15. Vacuum-deposited silver on polycarbonate with a chromium

    interlayer
    > : for improved
    > : > metal-
    > : > substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512;

    1/20/94.
    > : >
    > : > 16. Process for increased metal-substrate bond strength in metalized
    > : plastics.
    > : > Holmes-Farley, S.
    > : > R.; Ger. Offen. 4322516; 7/6/93.
    > : >
    > : > 17. Electrorheological fluids and preparation of particles useful in

    the
    > : fluids.
    > : > Troughton,
    > : > Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J.
    > : David; Bares, Joseph
    > : > E.;
    > : > Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP
    > : 394049;
    > : > 10/24/1990.
    > : >
    > : > JOURNAL PUBLICATIONS
    > : >
    > : > 1. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov,

    Eugene;
    > : Guo, Amy;
    > : > Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.;
    > : Mandeville, W. Harry;
    > : > Holmes-Farley, S. Randall. Kidney International (2002), 62(2),

    611-619.
    > : >
    > : > 2. Amine functionalized polyethers as bile acid sequestrants:

    synthesis
    > : and biological
    > : > evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S.

    Randall;
    > : Mandeville, W.
    > : > Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K.
    > : Journal of
    > : > Macromolecular Science, Pure and Applied Chemistry (2001), A38(12),
    > : 1559-1574.
    > : >
    > : > 3. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular
    > : Imprinting. Huval,
    > : > Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S.
    > : Randall; Mandeville,
    > : > W.
    > : > Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert

    J.;
    > : Chen, Xi; Dhal,
    > : > Pradeep K. Macromolecules (2001), 34(6), 1548-1550.
    > : >
    > : > 4. Synthetic polymers for the binding of fat in the intestinal tract.
    > : Jozefiak, Thomas H.;
    > : > Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia;

    Huval,
    > : Chad C.;
    > : > Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia.
    > : Abstracts of
    > : > Papers, 222nd ACS National Meeting, Chicago, IL, United States, August
    > : 26-30, 2001
    > : > (2001), POLY-047 and Polymer Preprints (American Chemical Society,
    > : Division of
    > : > Polymer Chemistry) (2001), 42(2), 98.
    > : >
    > : > 5. Colesevelam hydrochloride: Synthesis and testing of a novel polymer

    gel
    > : pharmaceutical.
    > : > Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.;

    Ward,
    > : J.; Sacchiero,
    > : > B.;
    > : > Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.;

    Chen,
    > : X.; Mazzeo, J.
    > : > R.. Polym. Preprints (2000), 41(1), 735-736.
    > : >
    > : > 6. In vitro comparison of bile acid binding to colesevelam HCl and

    other
    > : bile acid
    > : > sequestrants.
    > : > Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.;
    > : Hook, P.; Holmes-
    > : > Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.
    > : >
    > : > 7. Novel polymeric pharmaceuticals: From startup to market.

    Holmes-Farley,
    > : S. R; Polym.
    > : > Mater. Sci. Eng (1999), 80, 246-247.
    > : >
    > : > 8. Design and characterization of of Sevelamer Hydrochloride: a novel
    > : phosphate-binding
    > : > pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward,

    J.;
    > : Miller, K. L.;
    > : > Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure

    and
    > : Appl. Chem.,
    > : > A36(7&8), p. 1085 (1999).
    > : >
    > : > 9. Three generations of bile acid sequestrants. Mandeville, W. H.,

    III;
    > : Braunlin, W.;
    > : > Dhal, P.;
    > : > Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.;
    > : Rosenbaum, D.;
    > : > Sacchiero,
    > : > R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999),
    > : 550, 3-15.
    > : >
    > : > 10. Effect of RenaGel, a non-absorbable, crosslinked, polymeric

    phosphate
    > : binder, on
    > : > urinary
    > : > phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.;
    > : Mandeville, W. H.,
    > : > III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant.
    > : (1997), 12(5)
    > : > 961-964.
    > : >
    > : > 11. Thin anisotropic coatings based on sol-gel technology.

    Holmes-Farley,
    > : S. R.; Yanyo, L.
    > : > C;
    > : > Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4),

    439-444.
    > : >
    > : > 12. The mechanism of cure initiation of a surface activated adhesive.
    > : Holmes-Farley, S.
    > : > R.;
    > : > Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.
    > : >
    > : > 13. Adhesion promotion and corrosion prevention using thin anisotropic
    > : coatings. Holmes-
    > : > Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2),
    > : 131-151.
    > : >
    > : > 14. Wetting of functionalized polyethylene having ionizable organic

    acids
    > : and bases at the
    > : > polymer-water interface: relations between functional group polarity,
    > : extent of
    > : > ionization,
    > : > and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.;
    > : Whitesides, G. M.;
    > : > Langmuir
    > : > (1988), 4(4), 921-937.
    > : >
    > : > 15. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a
    > : single hydroxy group.
    > : > Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.
    > : >
    > : > 16. Reconstruction of the interface of oxidatively functionalized
    > : polyethylene (PE-CO2H)
    > : > and
    > : > derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo,

    R.;
    > : McCarthy, T. J.;
    > : > Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report

    (1987),
    > : AD-
    > : > A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).
    > : >
    > : > 17. Surface-modified polyethylene film: the relationship between

    surface
    > : chemistry and
    > : > physical
    > : > properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11),

    4537.
    > : >
    > : > 18. Reactivity of carboxylic acid and ester groups in the

    functionalized
    > : interfacial
    > : > region of
    > : > "polyethylene carboxylic acid" (PE-CO2H) and its derivatives:
    > : differentiation of the
    > : > functional groups into shallow and deep subsets based on a comparison

    of
    > : contact angle and
    > : > ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir
    > : (1987), 3(1), 62-
    > : > 76.
    > : >
    > : > 19. Fluorescence properties of dansyl groups covalently bonded tot he
    > : surface of
    > : > oxidatively
    > : > functionalized low-density polyethylene film. Holmes-Farley, S. R.;
    > : Whitesides, G. M.;
    > : > Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2;
    > : AD-A162435/2/GAR,
    > : > Gov. Rep. Announce. Index (U. S.) 1986, 86(7).
    > : >
    > : > 20. Acid-base behavior of carboxylic acid groups covalently attached

    at
    > : the surface of
    > : > polyethylene: The usefulness of contact angle in following the

    ionization
    > : of surface
    > : > functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.;
    > : Deutch, J.;
    > : > Whitesides,
    > : > G. M.; Langmuir (1985), 1(6), 725-740.
    > : >
    > : > 21. The thermal stability of a surface modified solid organic polymer.
    > : Holmes-Farley, S.
    > : > R.;
    > : > Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.
    > : >
    > : >
    > : >
    > : > CORAL REEF AQUARIA CHEMISTRY PUBLICATIONS (ON LINE)
    > : >
    > : > 1. The Seachem Borate Alkalinity Test Kit. Holmes-Farley, R. Advanced
    > : Aquarist. June 2003.
    > : >
    > : > 2. The Self Purification of Limewater (Kalkwasser). Holmes-Farley, R.
    > : Advanced Aquarist.
    > : > May
    > : > 2003.
    > : >
    > : > 3. The Degradation of Limewater (Kalkwasser) in Air. Holmes-Farley, R.
    > : Reefkeeping May
    > : > 2003.
    > : >
    > : > 4. Reef Aquaria with Low Soluble Metals. Holmes-Farley, R. Reefkeeping
    > : April 2003.
    > : >
    > : > 5. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; April 2003.
    > : >
    > : > 6. Iodine in Marine Aquaria: Part II Effects on Macroalgae Growth.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; April 2003.
    > : >
    > : > 7. Iodine in Marine Aquaria: Part I. Holmes-Farley, R. Advanced

    Aquarist;
    > : March 2003.
    > : >
    > : > 8. How to Select a Calcium and Alkalinity Supplementation Scheme.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist; February 2003.
    > : >
    > : > 9. Silica in a Reef Tank. Holmes-Farley, R. Advanced Aquarist; January
    > : 2003.
    > : >
    > : > 10. Boron in a Reef Tank. Holmes-Farley, R. Advanced Aquarist;

    December
    > : 2002.
    > : >
    > : > 11. Solving Calcium and Alkalinity Problems. Holmes-Farley, R.

    Advanced
    > : Aquarist; November
    > : > 2002.
    > : >
    > : > 12. Iron: A Look at Organisms Other than Macroalgae. Holmes-Farley, R.
    > : Advanced Aquarist;
    > : > November 2002.
    > : >
    > : > 13. Phosphorus: Algae's Best Friend. Holmes-Farley, R.; Advanced

    Aquarist,
    > : September 2002.
    > : >
    > : > 14. Iron in a Reef Tank. Holmes-Farley, R.; Advanced Aquarist, August
    > : 2002.
    > : >
    > : > 15. Calcium and Alkalinity. Holmes-Farley, R.; Reefkeeping.com, April
    > : 2002.
    > : >
    > : > 16. Calcium Carbonate as a Supplement. Holmes-Farley, R. Advanced
    > : Aquarist; July 2002
    > : >
    > : > 17. Solutions to pH Problems. Holmes-Farley, R. Advanced Aquarist;

    June
    > : 2002.
    > : >
    > : > 18. The Relationship Between Alkalinity and pH. Holmes-Farley, R.

    Advanced
    > : Aquarist, May
    > : > 2002.
    > : >
    > : > 19. The Chemical & Biochemical Mechanisms of Calcification in Corals.
    > : Holmes-Farley, R.
    > : > Advanced Aquarist, April 2002.
    > : >
    > : > 20. Calcium. Holmes-Farley, R. Advanced Aquarist; March 2002.
    > : >
    > : > 21. Alkalinity. Holmes-Farley, R. Advanced Aquarist; February 2002.
    > : >
    > : > 22. Specific Gravity. Holmes-Farley, R. Advanced Aquarist, January

    2002.
    > : >
    > : > 23. The Complete Nitrogen Cycle. Holmes-Farley, R. Aquarium Frontiers
    > : 2000.
    > : >
    > : > 24. Magnesium: Calcium's little sister. Holmes-Farley, R. Aquarium
    > : Frontiers 2000.
    > : >
    > : > 25. Phosphate..What is it and why should you care. Holmes-Farley, R.
    > : Aquarium Frontiers
    > : > 2000.
    > : > 26. Carbon Dioxide: Friend or Foe . Holmes-Farley, R. Aquarium

    Frontiers
    > : 2000.
    > : >
    > : > 27. Using Conductivity To Measure Salinity, R. Aquarium Frontiers

    2000.
    > : >
    > : > 28. Understanding Seawater. Holmes-Farley, R. Aquarium Frontiers 1999.
    > : >
    > : > 29. Protein Skimming: How it Works. Fishnet Library 1998.
    > : >
    > : >
    > : >
    > : >
    > : >
    > : >
    > : >
    > : > Boomer
    > : >
    > : > Want to talk chemistry ? The Reef Chemistry Forum
    > : > http://www.reefcentral.com/vbulletin/index.php
    > : >
    > : > Want to See More ?
    > : > Please Join Our Growing Membership
    > : > www.coralrealm.com
    > : >
    > : >
    > : >
    > :
    > :
    >
    >
     
    stoutman, Feb 11, 2004
    #58
  19. Dinky

    RicSeyler Guest

    HAHAHAHA!!!!!

    Marc Levenson wrote:

    >The King finds humor in this situation, and allows it to continue.
    >
    >For now.
    >
    >King Marc. :)
    >
    >Richard Reynolds wrote:
    >
    >
    >
    >>now ive done it the king is gona slap me around for messing with the oracle :D
    >>
    >>
    >>

    >
    >--
    >Personal Page: http://www.sparklingfloorservice.com/oanda/index.html
    >Business Page: http://www.sparklingfloorservice.com
    >Marine Hobbyist: http://www.melevsreef.com
    >
    >
    >
    >


    --
    Ric Seyler
    Online Racing: RicSeyler
    GPL Handicap 6.35
    ricseyler@SPAMgulf.net
    http://www.pcola.gulf.net/~ricseyler
    remove –SPAM- from email address
    --------------------------------------
    "Homer no function beer well without."
    - H.J. Simpson
     
    RicSeyler, Feb 11, 2004
    #59
  20. Dinky

    RicSeyler Guest

    We know who the winner is.....
    But your entitled to your opinion. LOL

    ReefTech wrote:

    >Looks to me like Boomer lost this one.
    >
    >
    >"Dragon Slayer" <koi_man@nospam_hotmail.com> wrote in message
    >news:c08a79$86iq$1@news3.infoave.net...
    >
    >
    >>Boomer when you read that, just let it go.............no need bashing
    >>
    >>

    >heads
    >
    >
    >>here, the group knows what's going on.
    >>
    >>kc
    >>
    >>"stoutman" <.@.> wrote in message
    >>
    >>

    >news:SFNVb.204571$Rc4.1681932@attbi_s54...
    >
    >
    >>>Oh brother. Where to start.
    >>>
    >>>pH is the -log of the hydronium ion concentration. When the hydronium
    >>>
    >>>

    >ion
    >
    >
    >>>concentration is very low, your system is basic (high pH). When the
    >>>hydronium ion concentration is very large, your system is acidic (low
    >>>
    >>>

    >pH).
    >
    >
    >>>pH + pOH = 14. So yeah, you can calculate a pH from a pOH and vice
    >>>
    >>>

    >versa.
    >
    >
    >>>But a pH of < 7 means acidic. pH > 7 means basic.
    >>>pH can tell you something about acidity and basicity. It is a
    >>>
    >>>

    >measurement
    >
    >
    >>>of both, or the entire pH scale (1-14) if you will.
    >>>
    >>>
    >>>
    >>>>It is called "blowing it off" , such as with an airstone. If you have
    >>>>
    >>>>

    >>high
    >>
    >>
    >>>CO2 and add an airstone it will drive the CO2 off raising the pH.
    >>>
    >>>Ok, you are going to try and 'purge' (the correct term) your CO2 out
    >>>
    >>>

    >with
    >
    >
    >>>air. Yeah, I guess that would work. If you intentionally put the CO2
    >>>
    >>>

    >in
    >
    >
    >>>there to begin with because you must have a higher concentration of CO2
    >>>
    >>>

    >in
    >
    >
    >>>your tank than in the atmosphere. I don't intentionally put CO2 in my
    >>>
    >>>

    >>tank.
    >>
    >>
    >>>But I know some of you reef people due in Kalk reactors.
    >>>
    >>>
    >>>
    >>>>If Alk resists changes in pH then why does CO2 lower the pH without
    >>>>
    >>>>
    >>>affecting the Alk.
    >>>
    >>>Alkalinity is buffering capacity. Your buffers begin to get weakened
    >>>
    >>>

    >with
    >
    >
    >>>the addition of acid until they reach a point when they can no longer
    >>>'buffer' and the pH crashes.
    >>>
    >>>
    >>>
    >>>>But I know what you mean, may use the term ALK and BC interchangeably
    >>>>
    >>>>
    >>>Do you remember writing this in an earlier post? If you believe that
    >>>alkalinity and buffering capacity can be used interchangeably than I
    >>>
    >>>

    >must
    >
    >
    >>be
    >>
    >>
    >>>getting through to you.
    >>>
    >>>
    >>>
    >>>>When CO2 is added or remove it just changes the ratio of CO2:HCO3:CO3.
    >>>>
    >>>>

    >At
    >
    >
    >>>any pH no matter what the Alk or CO2 there will be an exact ratio of
    >>>CO2:HCO3:CO3
    >>>
    >>>Yes, at any pH there will be 'SOME' ratio of CO2:HCO3-1:CO3-2. What is
    >>>
    >>>

    >>your
    >>
    >>
    >>>point here?
    >>>
    >>>
    >>>
    >>>>Go ahead and pick a seawater pH and I will tell you what that ratio
    >>>>
    >>>>

    >is.
    >
    >
    >>>Tell me the pH and
    >>>
    >>>
    >>>>Alk and I will give the CO2 concentration. Give me the Alk and CO2
    >>>>
    >>>>

    >and
    >
    >
    >>I
    >>
    >>
    >>>will give you
    >>>
    >>>
    >>>>the pH. Don't forget the temperature and Salinity.
    >>>>
    >>>>
    >>>Not interested. I can find my own software to do this too.
    >>>
    >>>
    >>>
    >>>>Alk is defined as;
    >>>>
    >>>>TA = [HCO3-] + 2[CO3--] + [B(OH)4-] + [OH-] + [Si(OH)3O-] + [MgOH+] +
    >>>>
    >>>>
    >>>[HPO4--] +
    >>>
    >>>
    >>>>2[PO4---] - [H+]
    >>>>
    >>>>
    >>>Ahh, now we are getting somewhere. What you are showing are components
    >>>
    >>>

    >of
    >
    >
    >>a
    >>
    >>
    >>>'BUFFER'. Which are used in the over all 'buffering capacity'. Are we
    >>>going in circles here? Anyway, I think you are learning something.
    >>>
    >>>
    >>>
    >>>>In any aqueous solution maximum BC is reached when pH= pKa. Seawaters
    >>>>
    >>>>
    >>>maximum BC is at a
    >>>
    >>>
    >>>>pH of 6 & 9. For all practically purposes seawater has very little
    >>>>
    >>>>
    >>>Buffering Capacity, if
    >>>
    >>>
    >>>>any at all.
    >>>>
    >>>>
    >>>This is the 'primary buffer' in sea water:
    >>>
    >>>H2O + CO2 <---> H2CO3 <---> H+ + HCO3-1
    >>>
    >>>If you REALLY believe that sea water has little buffering capacity, than
    >>>
    >>>

    >>you
    >>
    >>
    >>>need to do some reading on your own. I wont be able to convince you.
    >>>
    >>>
    >>>
    >>>>In any aqueous solution maximum BC is reached when pH= pKa. Seawaters
    >>>>
    >>>>
    >>>maximum BC is at a
    >>>
    >>>
    >>>>pH of 6 & 9. For all practically purposes seawater has very little
    >>>>
    >>>>
    >>>Buffering Capacity, if
    >>>
    >>>
    >>>>any at all.
    >>>>
    >>>>
    >>>This would be true if a monoprotic acid where used in the 'buffer', but
    >>>carbonic acid (the primary buffering component in seawater) is a
    >>>
    >>>

    >>polyprotic
    >>
    >>
    >>>acid. It has two protons that can dissociate. Therefore, it has two
    >>>
    >>>

    >>pKa's
    >>
    >>
    >>>(pKa1 and pKa2). pH = (pKa1 + pKa2)/2 pH = (6.4 + 10.3)/2 pH = 8.35.
    >>>
    >>>

    >>The
    >>
    >>
    >>>pH of seawater varies from 7.6 to 8.4. Hmmm. That pH I calculated is
    >>>right in there. Is that magic? :)
    >>>
    >>>Remember that seawater is more than a mixture of just carbonate and CO2,
    >>>there are other buffers involved that make it even more complicated I'm
    >>>sure.
    >>>
    >>>
    >>>
    >>>>By the way do you know who you are talking to ?
    >>>>
    >>>>
    >>>No. Do you?
    >>>
    >>>
    >>>
    >>>
    >>>"Boomer" <wcwing_nospam_@chartermi.net> wrote in message
    >>>news:102edca3c38a643@corp.supernews.com...
    >>>
    >>>
    >>>>Let me make this clear you don't know what you are taking about
    >>>>
    >>>>"alkalinity is a measurement of 'buffering capacity'"
    >>>>
    >>>>No, it is the ability to neutralize an acid. BC is the ability to
    >>>>
    >>>>
    >>>withstand both upward
    >>>
    >>>
    >>>>and downward trends in pH.
    >>>>
    >>>>"pH is a measurement of 'acidity/basicity'.
    >>>>
    >>>>No, pH is a measurement of acidity and pOH is a measurement of
    >>>>
    >>>>

    >Basicity,
    >
    >
    >>>if you want to
    >>>
    >>>
    >>>>get picky, which seems you do.
    >>>>
    >>>>
    >>>>"How do you remove CO2? "
    >>>>
    >>>>It is called "blowing it off" , such as with an airstone. If you have
    >>>>
    >>>>

    >>high
    >>
    >>
    >>>CO2 and add an
    >>>
    >>>
    >>>>airstone it will drive the CO2 off raising the pH. It can be proven
    >>>>
    >>>>

    >with
    >
    >
    >>a
    >>
    >>
    >>>glass of water,
    >>>
    >>>
    >>>>a straw, some pH color indicator and an Alk test kit and if you must a
    >>>>
    >>>>

    >>CO2
    >>
    >>
    >>>test kit
    >>>
    >>>
    >>>>>You can have all the alk you want in the world and it won't help, in
    >>>>>
    >>>>>
    >>>>regards to CO2
    >>>>
    >>>>"Wrong. Alkalinity increases your tank's ability to RESIST sharp
    >>>>
    >>>>

    >>changes
    >>
    >>
    >>>in
    >>>
    >>>
    >>>>pH. This is what is meant by 'buffering capacity'"
    >>>>
    >>>>No you are wrong and very lost. If Alk resists changes in pH then why
    >>>>
    >>>>

    >>does
    >>
    >>
    >>>CO2 lower the
    >>>
    >>>
    >>>>pH without affecting the Alk ? CO2 has no effect on alk and alk has no
    >>>>
    >>>>
    >>>effect on CO2. When
    >>>
    >>>
    >>>>CO2 is added or remove it just changes the ratio of CO2:HCO3:CO3. At
    >>>>
    >>>>

    >any
    >
    >
    >>>pH no matter what
    >>>
    >>>
    >>>>the Alk or CO2 there will be an exact ratio of CO2:HCO3:CO3
    >>>>
    >>>>.
    >>>>Go ahead and pick a seawater pH and I will tell you what that ratio
    >>>>
    >>>>

    >is.
    >
    >
    >>>Tell me the pH and
    >>>
    >>>
    >>>>Alk and I will give the CO2 concentration. Give me the Alk and CO2
    >>>>
    >>>>

    >and
    >
    >
    >>I
    >>
    >>
    >>>will give you
    >>>
    >>>
    >>>>the pH. Don't forget the temperature and Salinity.
    >>>>
    >>>>Alk is defined as;
    >>>>
    >>>>TA = [HCO3-] + 2[CO3--] + [B(OH)4-] + [OH-] + [Si(OH)3O-] + [MgOH+] +
    >>>>
    >>>>
    >>>[HPO4--] +
    >>>
    >>>
    >>>>2[PO4---] - [H+]
    >>>>
    >>>>
    >>>>Buffering Capacity is defined as;
    >>>>
    >>>>BC = dCb/dpH = 2.303 (Kw/ [H3O+] + [H30+] + CKa[H3O+] / (Ka +
    >>>>
    >>>>

    >[H3O+])²
    >
    >
    >>>>In any aqueous solution maximum BC is reached when pH= pKa. Seawaters
    >>>>
    >>>>
    >>>maximum BC is at a
    >>>
    >>>
    >>>>pH of 6 & 9. For all practically purposes seawater has very little
    >>>>
    >>>>
    >>>Buffering Capacity, if
    >>>
    >>>
    >>>>any at all.
    >>>>
    >>>>
    >>>>Alkalinity and Buffer Capacity are closely tied but are NOT the same
    >>>>
    >>>>
    >>>thing, it is a
    >>>
    >>>
    >>>>misunderstanding and use of the term. Do you think water chemistry
    >>>>
    >>>>

    >books
    >
    >
    >>>would have
    >>>
    >>>
    >>>>separate sections on Alkalinity and Buffering Capacity if they were
    >>>>
    >>>>

    >the
    >
    >
    >>>same thing ?
    >>>
    >>>
    >>>>By the way do you know who you are talking to ?
    >>>>
    >>>>--
    >>>>Boomer
    >>>>
    >>>>Want to talk chemistry ? The Reef Chemistry Forum
    >>>>http://www.reefcentral.com/vbulletin/index.php
    >>>>
    >>>>Want to See More ?
    >>>>Please Join Our Growing Membership
    >>>>www.coralrealm.com
    >>>>
    >>>>If You See Me Running You Better Catch-Up
    >>>>
    >>>>
    >>>>
    >>>>
    >>>
    >>>

    >>
    >>

    >
    >
    >
    >


    --
    Ric Seyler
    Online Racing: RicSeyler
    GPL Handicap 6.35
    ricseyler@SPAMgulf.net
    http://www.pcola.gulf.net/~ricseyler
    remove -SPAM- from email address
    --------------------------------------
    "Homer no function beer well without."
    - H.J. Simpson
     
    RicSeyler, Feb 11, 2004
    #60
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