You can easily run over 3000 gallons per hour through those bulk heads and still not reach your maximum capacity of the overflow box. I have run a Dart pump off an overflow box 18 long x 3" wide x 6" tall fed by two 2" bulkheads (it was very noisy and turbulent) and a Dart pump moves 3600 gallons per hour. My bulkheads are a total of 6.28 inches square, where your bulkheads are 5.30 inches square or 84% as big. 3600 x 0.84 = 3024 gallons per hour. Your overfow would have a capacity of 432 cu inches, where as mine is 324 cu inches, meaning my box is 25% smaller. My Overflow has 1/4 inch wide notches where as yours would not have notches, if made of glass (as Calfro usually suggests), so your flow through your box could be less limited than mine. Your limiting agent would therefore be your bulkheads and they will probably handle up to at least 1200 gph each. I do not know why you would ever want to move so much water through an overflow though as it would take a huge sump to take that kind of flow through it. I flow a maximum of 1000 gallons per hour through a 40 gallon sump or 800 gph through a 40 gallon sump/refugium. Any faster than this and all the bubbles flow right through the 40 gallon tank and into the display tank, even with bubble baffles. This set up your considering is for a 75 gallon tank. I would suggest an overflow handling around 750 to 800 gph and make up the rest of your tank circulation with a closed loop system or some -ugh- power heads. Even the highest flowing SPS tanks of 75 gallons would only flow around 3000 to 3750 gph in circulation, and most of that would be provided by closed loop circulation with just enough running through the sump/refugium to supply maybe double the capacity of the skimmer(s) so as to also feed raw water to the refugium.